1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. Procyclidine hydrochloride

Procyclidine hydrochloride (Synonyms: (±)-Procyclidine hydrochlorid)

Cat. No.: HY-B1487 Purity: 99.55%
Handling Instructions

Procyclidine hydrochloride is a potent anti-cholinergic agent, and is also known to have NMDA antagonist properties.

For research use only. We do not sell to patients.

Procyclidine hydrochloride Chemical Structure

Procyclidine hydrochloride Chemical Structure

CAS No. : 1508-76-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
100 mg USD 84 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Procyclidine hydrochloride is a potent anti-cholinergic agent, and is also known to have NMDA antagonist properties.

IC50 & Target

NMDA Receptor[1]

In Vivo

Procyclidine widely used as anti-parkinsonian agents because of their anti-cholinergic action, is also known to have NMDA antagonist properties. Unlike other NMDA antagonists, these agents-because of their anti-cholinergic action-are devoid of neurotoxic side effects. Procyclidine alleviates thermal hyperalgesia in a dose dependent manner; when a marginally effective dose of the agent is combined with an ineffective dose of an alpha(2) adrenergic agonist (Clonidine or Guanabenz), the combination therapy provides effective and long-lasting relief from neuropathic pain[1].

Molecular Weight









Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10.66 mg/mL (32.91 mM; Need ultrasonic and warming)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0874 mL 15.4369 mL 30.8737 mL
5 mM 0.6175 mL 3.0874 mL 6.1747 mL
10 mM 0.3087 mL 1.5437 mL 3.0874 mL
*Please refer to the solubility information to select the appropriate solvent.
Animal Administration

Adult Sprague-Dawley female rats (weight 300-330 g) are used. Procyclidine given systemically causes a transient increase in locomotor activity (mainly non-ambulatory fine movements) in adult rats. Locomotor activity data (ambulations, fine movements) are evaluated using a two-way ANOVA to test whether co-administration of clonidine (0.025 mg/kg) with various doses of Procyclidine (10, 25, 50 and 75 mg/kg) altered the activity levels compared to the same doses of Procyclidine administered alone. A one-way ANOVA and subsequent comparisons are also conducted to establish whether the activity levels for each treatment group are different from saline controls.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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