2. Procyclidine

Procyclidine  (Synonyms: Tricyclamol; (±)-Procyclidine)

Cat. No.: HY-B1487A
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Procyclidine (Tricyclamol; (±)-Procyclidine), an anticholinergic agent, is a muscarinic receptor antagonist that also has the properties of an N-methyl-D-aspartate (NMDA) antagonist. Procyclidine can be used in studies of Parkinson's disease and related psychiatric disorders such as Soman-induced epilepsy.

For research use only. We do not sell to patients.

Procyclidine Chemical Structure

Procyclidine Chemical Structure

CAS No. : 77-37-2

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Procyclidine Related Antibodies

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Description

Procyclidine (Tricyclamol; (±)-Procyclidine), an anticholinergic agent, is a muscarinic receptor antagonist that also has the properties of an N-methyl-D-aspartate (NMDA) antagonist. Procyclidine can be used in studies of Parkinson's disease and related psychiatric disorders such as Soman-induced epilepsy[1][2].

In Vivo

Procyclidine (subcutaneous injection, 0.3-6.0 mg/kg) in combination with physostigmine (PhS) increases protection in a dose-dependent manner in rats and guinea pigs infected with soman and can prevent seizures altogether[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats, Dunkin-Hartley male guinea pigs[1]
Dosage: 0.3-6.0 mg/kg
Administration: Subcutaneous injection; once
Result: Increased protection, resulting in 1.92, 2.24, 3.95 and 5.07 fold in rats, 3.00, 3.25, 4.50 and 4.70 fold in guinea pigs at the doses of 0.3, 1.0, 3.0 or 6.0 mg/kg, respectively.
Protected the neurological integrity of the brain and prevented Soman-induced severe brain damage in the hippocampus, cortex, amygdala and thalamus.
Molecular Weight

287.44

Formula

C19H29NO
CAS No.
SMILES

OC(C1=CC=CC=C1)(C2CCCCC2)CCN3CCCC3
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Keywords:

Procyclidine77-37-2Tricyclamol (±)-ProcyclidineInhibitorinhibitorinhibit

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