2. Anti-infection Apoptosis
  3. Antibiotic Apoptosis Bacterial
  4. Resistomycin

Resistomycin, a pentacyclic polyketide antibiotic, possesses anticancer activity and induces apoptosis.

Para uso exclusivo en investigación. No vendemos a pacientes.

Resistomycin

Resistomycin Estructura química

No. CAS : 20004-62-0

Tamaño Precio Stock Cantidad
1 mg En stock
5 mg   Obtener un presupuesto  
10 mg   Obtener un presupuesto  

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Revisión del cliente

Based on 1 Customer Validation

Resistomycin Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas Antibiotic:

Ver todas las isoformas
Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • Actividad biológica

  • Pureza y Documentación

  • Revisión del cliente

Descripciòn

Resistomycin, a pentacyclic polyketide antibiotic, possesses anticancer activity and induces apoptosis[1][2][3][4].

Cellular Effect
Cell Line Type Value Description References
CCRF-CEM IC50
0.5 μM
Compound: 1
Antiproliferative activity against human CEM cells after 72 hrs by MTT assay
Antiproliferative activity against human CEM cells after 72 hrs by MTT assay
[PMID: 29137865]
CCRF-CEM IC50
0.5 μM
Compound: 5
Antiproliferative activity against human CEM cells assessed as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human CEM cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 33974416]
HCT-116 IC50
0.1 μM
Compound: 1
Antiproliferative activity against p53 deficient human HCT116 cells after 72 hrs by MTT assay
Antiproliferative activity against p53 deficient human HCT116 cells after 72 hrs by MTT assay
[PMID: 29137865]
HCT-116 IC50
0.3 μM
Compound: 1
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
[PMID: 29137865]
HeLa IC50
0.1 μM
Compound: 1
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
[PMID: 29137865]
HeLa IC50
0.1 μM
Compound: 5
Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 33974416]
HMEC-1 IC50
0.5 μM
Compound: 1
Antiproliferative activity against HMEC1 cells after 72 hrs by MTT assay
Antiproliferative activity against HMEC1 cells after 72 hrs by MTT assay
[PMID: 29137865]
HMEC-1 IC50
0.5 μM
Compound: 5
Cytotoxicity against human HMEC-1 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HMEC-1 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 33974416]
K562 IC50
0.3 μM
Compound: 1
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
[PMID: 29137865]
L1210 IC50
0.7 μM
Compound: 1
Antiproliferative activity against mouse L1210 cells after 72 hrs by MTT assay
Antiproliferative activity against mouse L1210 cells after 72 hrs by MTT assay
[PMID: 29137865]
L1210 IC50
0.7 μM
Compound: 5
Antiproliferative activity against mouse L1210 cells assessed as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against mouse L1210 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 33974416]
T-24 IC50
26 μM
Compound: 1
Growth inhibition of human T24 cells after 72 hrs by cell impedance method
Growth inhibition of human T24 cells after 72 hrs by cell impedance method
[PMID: 29137865]
In Vitro

Resistomycin attenuates triple-negative breast cancer progression by inhibiting E3 ligase Pellino-1 and inducing SNAIL/SLUG degradation[1].
Resistomycin displays a high affinity for GST-Pellino-1 (KD = 2.58 μM) as indicated by surface plasmon resonance[1].
Resistomycin treatment reduced the expression of SNAIL and SLUG in TNBC cells[1].
Resistomycin induced apoptosis and cycle arrest in human hepatocellular carcinoma cells by activating p38 MAPK pathway in vitro and in vivo[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Resistomycin Related Antibodies
Peso molecular

376.36

Fòrmula

C22H16O6
No. CAS
Appearance

Solid

Color

Yellow to orange

SMILES

OC1=C(C(C2=C(O)C=C(C)C(C(O)=C3)=C2C4=C3C(C)(C)C5=O)=O)C4=C5C(O)=C1
Structure Classification
Initial Source

Streptomyces sulphureus
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Pureza y Documentación
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Resistomycin Related Classifications

  • Calculadora de molaridad

  • Calculadora de dilución

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Resistomycin20004-62-0AntibioticApoptosisBacterialapoptosiscell cycle arrestTNBCSNAILSLUGInhibitorinhibitorinhibit

Productos vistos recientemente:

Consulta en línea

Your information is safe with us. * Required Fields.

Nombre del producto

  

Requested Quantity *

Nombre del solicitante *

 

Saludo

Direcciòn del E-mail *

 

Número de teléfono *

Department

 

Nombre de la Organizaciòn *

City

Provincia

Country or Region *

      

Observaciones

Consulta para venta a granel

Inquiry Information

Nombre del producto:
Resistomycin
Cat. No.:
HY-N10449
Cantidad:
MCE Japan Authorized Agent:

Revisión del cliente

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Nombre del producto

  

Lot #

Nombre del solicitante *

 

Direcciòn del E-mail *

Número de teléfono

 

Department *

Nombre de la Organizaciòn *

 

Country or Region *

Observaciones

SAFETY DATA SHEET (SDS)

English - EN (557 KB) Français - FR (557 KB) Deutsch - DE (557 KB) Norwegian - NO (557 KB) Español - ES (557 KB) Swedish - SV (557 KB) Italian - IT (557 KB) Korean - KR (557 KB) Portuguese - PT (557 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.