2. Membrane Transporter/Ion Channel Neuronal Signaling Immunology/Inflammation
  3. nAChR Interleukin Related
  4. RVG

RVG  (Synonyms: RVG29; RDP; Rabies Virus Glycoprotein-29)

Art. -Nr.: HY-P5623 Reinheit: 99.81%
COA
SDS
Handling Instructions Technical Support

RVG (RVG29) is a blood-brain barrier-permeable peptide derived from rabies virus glycoprotein, which binds to the α-7 subunit of neuronal nicotinic acetylcholine receptor (AchR). RVG efficiently delivers drugs to nerve cells and antigen-presenting cells in a targeted manner, and enhances the efficiency of antigen presentation and drug delivery.

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Kundenspezifische Peptidsynthese

RVG

RVG Chemische Struktur

CAS. Nr. : 115136-25-9

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Based on 1 publication(s) in Google Scholar

Other Forms of RVG:

RVG Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE RVG

Alle Interleukin Related Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Beschreibung

RVG (RVG29) is a blood-brain barrier-permeable peptide derived from rabies virus glycoprotein, which binds to the α-7 subunit of neuronal nicotinic acetylcholine receptor (AchR). RVG efficiently delivers drugs to nerve cells and antigen-presenting cells in a targeted manner, and enhances the efficiency of antigen presentation and drug delivery[1][2].

In Vitro

RVG (500 ng/mL; 4 h) induces a basal level of IL-2 response in co-cultured BB7-T cell hybridomas with mouse bone marrow-derived dendritic cells (BMDCs)[1].
RVG (1 μg/mL; 4 h) induces a non-specific, MG132-independent basal IL-2 response in co-cultured F9A6-T cell hybridomas in human THP-1-derived macrophages[1].
At concentrations of 0.5-5.0 μg/mL for 4 h, RVG slightly increases the proportion of IL-12-secreting cells in mouse bone marrow-derived dendritic cells (BMDCs) compared with the unstimulated control group, but causes no dose-dependent enhancement of IL-12 secretion[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RVG Related Antibodies
In Vivo

RVG (10 µg; s.c./i.n.; three doses at 14-day intervals) does not significantly enhance 85B241-specific Th1 immune responses or humoral responses via subcutaneous or intranasal routes in naive mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (6-week-old female)[1]
Dosage: 10 µg (s.c.); 10 µg (i.n.)
Administration: s.c.; three doses at 14-day intervals; i.n.; three doses at 14-day intervals
Result: Exhibited 85B241 peptide-specific IFN-γ producing splenocyte counts not significantly different from counts in mice immunized with 85B241 alone via subcutaneous route.
Produced IFN-γ, IL-2, and TNF-α levels upon in vitro restimulation with 85B241 peptide not significantly different from levels in mice immunized with 85B241 alone.
Induced 85B241-specific IgG levels with no significant difference compared to mice immunized with 85B241 alone via subcutaneous route; induced no detectable 85B241-specific IgG via intranasal route.
Molekulargewicht

3266.62

Formel

C141H217N43O43S2
CAS. Nr.
Appearance

Solid

Color

White to off-white

Sequence

Tyr-Thr-Ile-Trp-Met-Pro-Glu-Asn-Pro-Arg-Pro-Gly-Thr-Pro-Cys-Asp-Ile-Phe-Thr-Asn-Ser-Arg-Gly-Lys-Arg-Ala-Ser-Asn-Gly
Sequence Shortening

YTIWMPENPRPGTPCDIFTNSRGKRASNG
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 10 mg/mL (3.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3061 mL 1.5306 mL 3.0613 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation

Purity: 99.81%

SDS (254 KB)

COA (243 KB) LCMS (95 KB) Elemental Analysis Report (100 KB)

Handling Instructions (2659 KB)
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.3061 mL 1.5306 mL 3.0613 mL 7.6532 mL
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RVG Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RVG115136-25-9RVG29 RDP Rabies Virus Glycoprotein-29RVG 29RVG-29Rabies Virus Glycoprotein29Rabies Virus Glycoprotein 29Rabies Virus Glycoprotein-29nAChRInterleukin RelatedNicotinic acetylcholine receptorsILmacrophagesdendritic cellsIL-2blood-brain barrierAchR-α7IL-12TNF-αsplenocytesIFN-γInhibitorinhibitorinhibit

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