115136-25-9
Chemical Structure
RVG
Synonym(s): RVG29; RDP; Rabies Virus Glycoprotein-29
- CAS No.: 115136-25-9
- Formula:C141H217N43O43S2
- Molecular Weight:3266.62
SMILES: C([C@@H](C(N[C@H](C(=O)N1[C@H](C(N[C@H](C(N[C@H](C(=O)N2[C@H](C(N[C@H](C(=O)N3[C@H](C(NCC(N[C@H](C(=O)N4[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC5=CC=CC=C5)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(O)=O)=O)CC(N)=O)=O)CO)=O)C)=O)CCCNC(=N)N)=O)CCCCN)=O)=O)CCCNC(=N)N)=O)CO)=O)CC(N)=O)=O)[C@@H](C)O)=O)=O)[C@H](CC)C)=O)CC(O)=O)=O)CS)=O)CCC4)[C@@H](C)O)=O)=O)CCC3)CCCNC(=N)N)=O)CCC2)CC(N)=O)=O)CCC(O)=O)=O)CCC1)CCSC)=O)NC([C@@H](NC([C@@H](NC([C@H](CC6=CC=C(O)C=C6)N)=O)[C@@H](C)O)=O)[C@H](CC)C)=O)C=7C=8C(NC7)=CC=CC8
Biological Activity: RVG (RVG29) is a blood-brain barrier-permeable peptide derived from rabies virus glycoprotein, which binds to the α-7 subunit of neuronal nicotinic acetylcholine receptor (AchR). RVG efficiently delivers drugs to nerve cells and antigen-presenting cells in a targeted manner, and enhances the efficiency of antigen presentation and drug delivery[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
RVG | 99.81% | RVG (RVG29) is a blood-brain barrier-permeable peptide derived from rabies virus glycoprotein, which binds to the α-7 subunit of neuronal nicotinic acetylcholine receptor (AchR). RVG efficiently delivers drugs to nerve cells and antigen-presenting cells in a targeted manner, and enhances the efficiency of antigen presentation and drug delivery. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.97
HY-P5623ARVG-Cys -
Similarity Score 0.80
HY-P4689Prolactin-Releasing Peptide (1-31) (rat) -
Similarity Score 0.80
HY-P4731Kisspeptin-54 (27-54) (human) -
Similarity Score 0.79
HY-P4086Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) -
Similarity Score 0.79
HY-P11706MS1 peptide -
Similarity Score 0.78
HY-P4874ACTH (7-38) (human) -
Similarity Score 0.77
HY-P1223Exendin-3/4 (59-86) -
Similarity Score 0.77
HY-P0264Exendin(9-39) amide -
Similarity Score 0.76
HY-P10267Neuromedin (B-30) -
Explore the MedChemAI to find more analogs
References
- [1]. Garnica O, et al. Enhanced delivery of Mycobacterium tuberculosis antigens to antigen presenting cells using RVG peptide. Tuberculosis (Edinb). 2019 May;116S:S34-S41. [Content Brief]
- [2]. Hou J, et al. α-lipoic acid nanoparticles functionalized with RVG29 peptide attenuate seizure-induced neurotoxicity by restoring mitochondrial homeostasis via the PINK1/Parkin pathway. Free Radic Biol Med. 2026;245:201-222. [Content Brief]
