1. GPCR/G Protein
  2. Glucagon Receptor

Exendin 9-39 (Synonyms: Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2; DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2)

Cat. No.: HY-P0264 Purity: 96.69%
Handling Instructions

Exendin (9-39) is a specific and competitive glucagon-like peptide-1 receptor antagonist.

For research use only. We do not sell to patients.
Exendin 9-39 Chemical Structure

Exendin 9-39 Chemical Structure

CAS No. : 133514-43-9

Size Price Stock Quantity
10 mM * 1 mL in Water USD 7206 In-stock
500 ug USD 204 In-stock
1 mg USD 324 In-stock
5 mg USD 972 In-stock
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


Exendin (9-39) is a specific and competitive glucagon-like peptide-1 receptor antagonist.

In Vitro

GLP-1 plays a role in the control of fasting glucose. Exendin-(9-39), a truncated form of the GLP-1 agonist exendin-4, is a specific GLP-1 receptor antagonist in mice and humans. Exendin (9-39) significantly inhibits amino acid-stimulated insulin secretion in pancreatic islets isolated from neonates with KATPHI[1].

In Vivo

Insulin-to-glucose ratios are significantly lower during Exendin (9-39) infusion compared with vehicle[1]. Continuous subcutaneous infusion of exendin-(9-39) significantly raises fasting blood glucose levels in SUR-1 −/− mice without affecting glucose tolerance or insulin sensitivity[2].

Clinical Trial
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 0.2968 mL 1.4838 mL 2.9676 mL
5 mM 0.0594 mL 0.2968 mL 0.5935 mL
10 mM 0.0297 mL 0.1484 mL 0.2968 mL
Please refer to the solubility information to select the appropriate solvent.
Animal Administration

Exendin (9-39) is formulated in 0.9% NaCl, 1% bovine serum albumin.

Mice: Alzet miniosmotic pumps are implanted subcutaneously to deliver exendin (9-39) at a rate of 150 pmol/kg/min or vehicle (0.9% NaCl, 1% bovine serum albumin) for 2 weeks[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight







O=C([[email protected]](CO)NC([[email protected]](CC(C)C)NC([[email protected]@H](N)CC(O)=O)=O)=O)N[[email protected]@H](CCCCN)C(NC(CCC(N)=O)C(N[[email protected]@H](CCSC)C(N[[email protected]@H](CCC(O)=O)C(N[[email protected]@H](CCC(O)=O)C(N[[email protected]@H](CCC(O)=O)C(N[[email protected]@H](C)C(N[[email protected]@H](C(C)C)C(N[[email protected]@H](CCCNC(N)=N)C(N[[email protected]@H](CC(C)C)C(N[[email protected]@H](CC1=CC=CC=C1)C(N[[email protected]]([[email protected]@H](C)CC)([H])C(N[[email protected]@H](CCC(O)=O)C(N[[email protected]](C(N[[email protected]@H](CC(C)C)C(N[[email protected]@H](CCCCN)C(N[[email protected]@H](CC(N)=O)C(NCC(NCC(N2[[email protected]@H](CCC2)C(N[[email protected]@H](CO)C(N[[email protected]@H](CO)C(NCC(N[[email protected]@H](C)C(N3[[email protected]@H](CCC3)C(N4[[email protected]@H](CCC4)C(N5[[email protected]@H](CCC5)C(N[[email protected]@H](CO)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC6=CNC7=CC=CC=C67)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility


* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Inquiry Online

Your information is safe with us. * Required Fields.

Product name



Applicant name *


Email address *

Phone number *


Organization name *

Country *


Requested quantity *


Bulk Inquiry

Inquiry Information

Product Name:
Exendin 9-39
Cat. No.: