RVG (Synonyms: RVG29; RDP; Rabies Virus Glycoprotein-29)

Name: RVG
Brand: MedChemExpress
SKU: HY-P5623
Rating: 4.5 (1 reviews)

Cat. No.: HY-P5623 Purity: 99.81%: Data Sheet
COA

SDS
Handling Instructions
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RVG (RVG29) is a blood-brain barrier-permeable peptide derived from rabies virus glycoprotein, which binds to the α-7 subunit of neuronal nicotinic acetylcholine receptor (AchR). RVG efficiently delivers drugs to nerve cells and antigen-presenting cells in a targeted manner, and enhances the efficiency of antigen presentation and drug delivery.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

RVG Chemical Structure

CAS No. : 115136-25-9

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of RVG:

RVG-Cys In-stock
RVG-Cys acetate In-stock
RVG TFA In-stock

1 Publications Citing Use of MCE RVG

•Free Radic Biol Med. 2025 Dec 23:245:201-222. [Abstract]

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

RVG (500 ng/mL; 4 h) induces a basal level of IL-2 response in co-cultured BB7-T cell hybridomas with mouse bone marrow-derived dendritic cells (BMDCs)^[1].
RVG (1 μg/mL; 4 h) induces a non-specific, MG132-independent basal IL-2 response in co-cultured F9A6-T cell hybridomas in human THP-1-derived macrophages^[1].
At concentrations of 0.5-5.0 μg/mL for 4 h, RVG slightly increases the proportion of IL-12-secreting cells in mouse bone marrow-derived dendritic cells (BMDCs) compared with the unstimulated control group, but causes no dose-dependent enhancement of IL-12 secretion^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

RVG (10 µg; s.c./i.n.; three doses at 14-day intervals) does not significantly enhance 85B₂₄₁-specific Th1 immune responses or humoral responses via subcutaneous or intranasal routes in naive mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 (6-week-old female)^[1]
Dosage:	10 µg (s.c.); 10 µg (i.n.)
Administration:	s.c.; three doses at 14-day intervals; i.n.; three doses at 14-day intervals
Result:	Exhibited 85B₂₄₁ peptide-specific IFN-γ producing splenocyte counts not significantly different from counts in mice immunized with 85B₂₄₁ alone via subcutaneous route. Produced IFN-γ, IL-2, and TNF-α levels upon in vitro restimulation with 85B₂₄₁ peptide not significantly different from levels in mice immunized with 85B₂₄₁ alone. Induced 85B₂₄₁-specific IgG levels with no significant difference compared to mice immunized with 85B₂₄₁ alone via subcutaneous route; induced no detectable 85B₂₄₁-specific IgG via intranasal route.

Molecular Weight

3266.62

Formula

C₁₄₁H₂₁₇N₄₃O₄₃S₂

CAS No.

115136-25-9

Appearance

Solid

Color

White to off-white

Sequence

Tyr-Thr-Ile-Trp-Met-Pro-Glu-Asn-Pro-Arg-Pro-Gly-Thr-Pro-Cys-Asp-Ile-Phe-Thr-Asn-Ser-Arg-Gly-Lys-Arg-Ala-Ser-Asn-Gly

Sequence Shortening

YTIWMPENPRPGTPCDIFTNSRGKRASNG

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 10 mg/mL (3.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.3061 mL	1.5306 mL	3.0613 mL
5 mM	---	---	---
10 mM	---	---	---

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.81%

Select Batch:

Data Sheet (272 KB) SDS (254 KB)

COA (243 KB) LCMS (95 KB) Elemental Analysis Report (100 KB)

Handling Instructions (2659 KB)

References

[1]. Garnica O, et al. Enhanced delivery of Mycobacterium tuberculosis antigens to antigen presenting cells using RVG peptide. Tuberculosis (Edinb). 2019 May;116S:S34-S41. [Content Brief]

[2]. Hou J, et al. α-lipoic acid nanoparticles functionalized with RVG29 peptide attenuate seizure-induced neurotoxicity by restoring mitochondrial homeostasis via the PINK1/Parkin pathway. Free Radic Biol Med. 2026;245:201-222. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO

1 mM

0.3061 mL

1.5306 mL

3.0613 mL

7.6532 mL

RVG Related Classifications

Neurological Disease Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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RVG (Synonyms: RVG29; RDP; Rabies Virus Glycoprotein-29)

Customer Review

Other Forms of RVG:

RVG Related Antibodies

1 Publications Citing Use of MCE RVG

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•Related Small Molecules:

•Related Proteins:

View All Interleukin Related Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

RVG Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

RVG Related Classifications

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