(S)-AMPA (Synonyms: L-AMPA)

Name: (S)-AMPA
Brand: MedChemExpress
SKU: HY-100815A
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Cat. No.: HY-100815A Pureté: 99%: Fiche technique
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(S)-AMPA (L-AMPA), an active S-enantiomer of AMPA, is a potent and selective AMPA receptor agonist.

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(S)-AMPA Chemical Structure

CAS No. : 83643-88-3

Size	Stock	Quantité
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtenir un devis
500 mg	Obtenir un devis

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Other Forms of (S)-AMPA:

(RS)-AMPA monohydrate In-stock
(R)-AMPA Obtenir un devis

Recommandations en vedette

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform iGluR:

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AMPA Receptor NMDA Receptor Kainate Receptor

Activité biologique
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Description

(S)-AMPA (L-AMPA), an active S-enantiomer of AMPA, is a potent and selective AMPA receptor agonist^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	>1 2 Compound: (S)-7	Agonist activity of the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu1-alpha Agonist activity of the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu1-alpha	[PMID: 8759641]
CHO	EC₅₀	220 3 Compound: (S)-7	Agonist activity of the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu6 Agonist activity of the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu6	[PMID: 8759641]
CHO	EC₅₀	> 1000 3 Compound: (S)-7	Agonist activity of the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu1-alpha Agonist activity of the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu1-alpha	[PMID: 8759641]
CHO	EC₅₀	>3 2 Compound: (S)-7	Agonist activity of the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu4a Agonist activity of the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu4a	[PMID: 8759641]
CHO	EC₅₀	> 1000 3 Compound: (S)-7	Agonist activity of the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu2 Agonist activity of the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu2	[PMID: 8759641]
CHO	EC₅₀	220 3 Compound: (S)-7	Agonist activity of the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu6 Agonist activity of the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu6	[PMID: 8759641]
CHO	EC₅₀	> 3000 3 Compound: (S)-7	Agonist activity of the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu4a Agonist activity of the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu4a	[PMID: 8759641]

In Vitro

Superfusion of (S)-AMPA (1 μM) significantly attenuates CGRP release in a CB1-dependent manner^[3].
24-h exposure to (S)-AMPA (0.01-1000 μM) induces concentration-dependent neuronal cell death (EC₅₀ of 3 μM) with cellular changes including neurite blebbing, chromatin condensation, and DNA fragmentation, indicative of apoptosis^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Masse moléculaire

186.17

Formule

C₇H₁₀N₂O₄

CAS No.

83643-88-3

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1C(C[C@H](N)C(O)=O)=C(C)ON1

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvant et solubilité

In Vitro:

H₂O : 40 mg/mL (214.86 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.3714 mL	26.8572 mL	53.7143 mL
5 mM	1.0743 mL	5.3714 mL	10.7429 mL
10 mM	0.5371 mL	2.6857 mL	5.3714 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculateur de molarité
Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureté et documentation

Purity: 99%

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Fiche technique (275 KB) SDS (393 KB)

COA (251 KB)

Instruction de manipulation (2659 KB)

Références

[1]. J A Larm, et al. (S)-5-fluorowillardiine-mediated neurotoxicity in cultured murine cortical neurones occurs via AMPA and kainate receptors. Eur J Pharmacol. 1996 Oct 24;314(1-2):249-54. [Content Brief]

[2]. B Ebert, et al. Molecular pharmacology of the AMPA agonist, (S)-2-amino-3-(3-hydroxy-5-phenyl-4-isoxazolyl)propionic acid [(S)-APPA] and the AMPA antagonist, (R)-APPA. Neurochem Int. 1994 Jun;24(6):507-15. [Content Brief]

[3]. J W Brooks, et al. (S)-AMPA inhibits electrically evoked calcitonin gene-related peptide (CGRP) release from the rat dorsal horn: reversal by cannabinoid receptor antagonist SR141716A. Neurosci Lett. 2004 Nov 30;372(1-2):85-8. [Content Brief]

[4]. J A Larm, et al. Apoptosis induced via AMPA-selective glutamate receptors in cultured murine cortical neurons. J Neurochem. 1997 Aug;69(2):617-22. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.3714 mL	26.8572 mL	53.7143 mL	134.2859 mL
	5 mM	1.0743 mL	5.3714 mL	10.7429 mL	26.8572 mL
	10 mM	0.5371 mL	2.6857 mL	5.3714 mL	13.4286 mL
	15 mM	0.3581 mL	1.7905 mL	3.5810 mL	8.9524 mL
	20 mM	0.2686 mL	1.3429 mL	2.6857 mL	6.7143 mL
	25 mM	0.2149 mL	1.0743 mL	2.1486 mL	5.3714 mL
	30 mM	0.1790 mL	0.8952 mL	1.7905 mL	4.4762 mL
	40 mM	0.1343 mL	0.6714 mL	1.3429 mL	3.3571 mL
	50 mM	0.1074 mL	0.5371 mL	1.0743 mL	2.6857 mL
	60 mM	0.0895 mL	0.4476 mL	0.8952 mL	2.2381 mL
	80 mM	0.0671 mL	0.3357 mL	0.6714 mL	1.6786 mL
	100 mM	0.0537 mL	0.2686 mL	0.5371 mL	1.3429 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

(S)-AMPA Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-AMPA83643-88-3L-AMPAiGluRIonotropic glutamate receptorsAMPAS-enantiomerCB1Inhibitorinhibitorinhibit

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(S)-AMPA (Synonyms: L-AMPA)

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Other Forms of (S)-AMPA:

(S)-AMPA Related Antibodies

Recommandations en vedette

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform iGluR:

Activité biologique

Pureté et documentation

Références

Avis client

(S)-AMPA Related Antibodies

Calculateur de molarité

Calculateur de dilution

Complete Stock Solution Preparation Table

(S)-AMPA Related Classifications

Keywords:

Vos produits récemment consultés:

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