2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. (R)-AMPA

(R)-AMPA is an inactive AMPA receptor ligand that inhibits the release of excitatory amino acids from neurons. (R)-AMPA is inactive in experiments that enhance the release of [3H]D-aspartate induced by electrical stimulation. (R)-AMPA is inhibited by competitive and noncompetitive AMPA receptor selective antagonists in response to AMPA and glutamate.

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(R)-AMPA

(R)-AMPA Chemical Structure

CAS No. : 83654-13-1

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Other Forms of (R)-AMPA:

(R)-AMPA Related Antibodies

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AMPA Receptor NMDA Receptor Kainate Receptor

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Description

(R)-AMPA is an inactive AMPA receptor ligand that inhibits the release of excitatory amino acids from neurons. (R)-AMPA is inactive in experiments that enhance the release of [3H]D-aspartate induced by electrical stimulation. (R)-AMPA is inhibited by competitive and noncompetitive AMPA receptor selective antagonists in response to AMPA and glutamate[1].

Cellular Effect
Cell Line Type Value Description References
CHO EC50
> 1000 μM
Compound: (R)-7
Agonist activity of the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu1-alpha
Agonist activity of the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu1-alpha
[PMID: 8759641]
CHO EC50
> 1000 μM
Compound: (R)-7
Agonist activity of the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu2
Agonist activity of the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu2
[PMID: 8759641]
CHO EC50
> 1000 μM
Compound: (R)-7
Agonist activity of the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu6
Agonist activity of the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu6
[PMID: 8759641]
Molecular Weight

186.17

Formula

C7H10N2O4
CAS No.
SMILES

O=C1C(C[C@@H](N)C(O)=O)=C(C)ON1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(R)-AMPA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-AMPA83654-13-1iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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