Cyclothiazide

Cat. No.: HY-101165: Data Sheet Handling Instructions

Cyclothiazide, a positive allosteric modulator of AMPA receptors, is used frequently to block the desensitization of both native and heterologously expressed AMPA receptors. Cyclothiazide is known to produce a fast inhibition of AMPA receptor desensitization and a much slower potentiation of the AMPA current.

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Cyclothiazide Chemical Structure

CAS No. : 2259-96-3

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Description	Cyclothiazide, a positive allosteric modulator of AMPA receptors, is used frequently to block the desensitization of both native and heterologously expressed AMPA receptors. Cyclothiazide is known to produce a fast inhibition of AMPA receptor desensitization and a much slower potentiation of the AMPA current^[1].
Molecular Weight	389.88
Formula	C₁₄H₁₆ClN₃O₄S₂
CAS No.	2259-96-3
SMILES	O=S(C1=C(Cl)C=C(C2=C1)NC(C3C(C4)C=CC4C3)NS2(=O)=O)(N)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
References	[1]. Fucile S, et al. Effects of cyclothiazide on GluR1/AMPA receptors. Proc Natl Acad Sci U S A. 2006;103(8):2943-2947.

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Keywords:

Cyclothiazide2259-96-3iGluRIonotropic glutamate receptorsAMPA receptor desensitizationpositive allosteric modulatorcurrent potentiationneuronesInhibitorinhibitorinhibit

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Cyclothiazide

Biological Activity

Purity & Documentation

References

Customer Review

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