(RS)-AMPA hydrochloride
(RS)-AMPA hydrochloride ((±)-AMPA hydrochloride) is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA hydrochloride hydrobromide does not interfere with binding sites for kainic acid or NMDA receptors.
For research use only. We do not sell to patients.
- CAS No.: 2922283-04-1
- Formula: C7H11ClN2O4
- Molecular Weight:222.63
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
(RS)-AMPA hydrochloride induces dose-dependent depolarization in cultured fetal rat brainstem and lumbosacral spinal cord neurons by activating glutamate/quisqualate-preferring receptors[1].
(RS)-AMPA hydrochloride activates recombinant GluR-A/GluR-B AMPA receptors in cultured mammalian cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2922283-04-1
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Appearance Solid
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Molecular Weight 222.63
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Formula C7H11ClN2O4
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Color White to off-white
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SMILES
O=C1NOC(C)=C1CC(C(O)=O)N.Cl
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Synonyms
(±)-AMPA hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 125 mg/mL (561.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Hösli L, et al. Effects of the glutamate analogue AMPA and its interaction with antagonists on cultured rat spinal and brain stem neurones. Neurosci Lett. 1983;36(1):59-62. [Content Brief]
[2]. Sommer B, et al. Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. Science. 1990;249(4976):1580-1585. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.4918 mL | 22.4588 mL | 44.9176 mL | 112.2939 mL |
| 5 mM | 0.8984 mL | 4.4918 mL | 8.9835 mL | 22.4588 mL | |
| 10 mM | 0.4492 mL | 2.2459 mL | 4.4918 mL | 11.2294 mL | |
| 15 mM | 0.2995 mL | 1.4973 mL | 2.9945 mL | 7.4863 mL | |
| 20 mM | 0.2246 mL | 1.1229 mL | 2.2459 mL | 5.6147 mL | |
| 25 mM | 0.1797 mL | 0.8984 mL | 1.7967 mL | 4.4918 mL | |
| 30 mM | 0.1497 mL | 0.7486 mL | 1.4973 mL | 3.7431 mL | |
| 40 mM | 0.1123 mL | 0.5615 mL | 1.1229 mL | 2.8073 mL | |
| 50 mM | 0.0898 mL | 0.4492 mL | 0.8984 mL | 2.2459 mL | |
| 60 mM | 0.0749 mL | 0.3743 mL | 0.7486 mL | 1.8716 mL | |
| 80 mM | 0.0561 mL | 0.2807 mL | 0.5615 mL | 1.4037 mL | |
| 100 mM | 0.0449 mL | 0.2246 mL | 0.4492 mL | 1.1229 mL |
(RS)-AMPA hydrochloride Related Classifications
HY-100815E Related Classifications
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