1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. (RS)-AMPA

(RS)-AMPA (Synonyms: (±)-AMPA)

Cat. No.: HY-100815B
Handling Instructions

(RS)-AMPA ((±)-AMPA) is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA does not interfere with binding sites for kainic acid or NMDA receptors.

For research use only. We do not sell to patients.

(RS)-AMPA Chemical Structure

(RS)-AMPA Chemical Structure

CAS No. : 77521-29-0

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Description

(RS)-AMPA ((±)-AMPA) is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA does not interfere with binding sites for kainic acid or NMDA receptors[1][2].

In Vitro

(RS)-AMPA (10-3-10-4 M) causes depolarizations of cultured rat spinal and brainstem neurones. The depolarization by (RS)-AMPA is clearly dose-dependent, although there is a great variability of effects between individual neurones. Application of (RS)-AMPA at 10-5 M produces only small depolarizations (3-7 mV), whereas at 10-4 M, the amplitudes of the depolarizations ranged from 4 to 33 mV. (RS)-AMPA also causes an increase of the discharge rate of spontaneously firing neurones or sometimes evoked a short burst of action potentials in silent cells. (RS)-AMPA exerts its depolarizing effects by activating glutamate/quisqualate receptors without affecting NMDA receptors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

186.17

Formula

C₇H₁₀N₂O₄

CAS No.

77521-29-0

SMILES

O=C1C(CC(N)C(O)=O)=C(C)ON1

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

(RS)-AMPA(±)-AMPAiGluRIonotropic glutamate receptorsDepolarizationsmotoneuronesinterneuronesglutamateCNSkainicL-glutamicneurotransmitterNMDAInhibitorinhibitorinhibit

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(RS)-AMPA
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