83643-88-3
83643-88-3
Chemical Structure
(S)-AMPA
Synonym(s): L-AMPA
- CAS. Nr.: 83643-88-3
- Formula:C7H10N2O4
- Molecular Weight:186.17
IUPAC Name: (S)-2-amino-3-(5-methyl-3-oxo-2,3-dihydroisoxazol-4-yl)propanoic acid
InChIKey: UUDAMDVQRQNNHZ-YFKPBYRVSA-N
SMILES: O=C1C(C[C@H](N)C(O)=O)=C(C)ON1
Biological Activity: (S)-AMPA (L-AMPA), an active S-enantiomer of AMPA, is a potent and selective AMPA receptor agonist[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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(S)-AMPA | 99% | (S)-AMPA (L-AMPA), an active S-enantiomer of AMPA, is a potent and selective AMPA receptor agonist. | ||||||||||||||||||||
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(R)-AMPA | (R)-AMPA is an inactive AMPA receptor ligand that inhibits the release of excitatory amino acids from neurons. (R)-AMPA is inactive in experiments that enhance the release of [3H]D-aspartate induced by electrical stimulation. (R)-AMPA is inhibited by competitive and noncompetitive AMPA receptor selective antagonists in response to AMPA and glutamate. | |||||||||||||||||||||
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(RS)-AMPA (Standard) | ≥98% | (RS)-AMPA (Standard) ((±)-AMPA (Standard)) is the analytical standard of (RS)-AMPA (HY-100815B). This product is intended for research and analytical applications. (RS)-AMPA ((±)-AMPA) is the racemate of AMPA. (RS)-AMPA is a glutamate analogue and a potent, selective agonist of the excitatory neurotransmitter L-glutamic acid. (RS)-AMPA does not interfere with the binding sites of kainate or NMDA receptors. | ||||||||||||||||||||
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(RS)-AMPA hydrobromide | 99.50% | (RS)-AMPA hydrobromide ((±)-AMPA hydrobromide) is the racemate of AMPA. (RS)-AMPA hydrobromide is a glutamate analogue and a potent, selective agonist of the excitatory neurotransmitter L-glutamic acid. (RS)-AMPA hydrobromide does not interfere with the binding sites of kainate or NMDA receptors. | ||||||||||||||||||||
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(RS)-AMPA monohydrate | 99.90% | (RS)-AMPA monohydrate ((±)-AMPA monohydrate) is the racemate of AMPA. (RS)-AMPA monohydrate is a glutamate analogue and a potent, selective agonist of the excitatory neurotransmitter L-glutamic acid. (RS)-AMPA monohydrate does not interfere with the binding sites of kainate or NMDA receptors. | ||||||||||||||||||||
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(RS)-AMPA hydrochloride | (RS)-AMPA hydrochloride ((±)-AMPA hydrochloride) is the racemate of AMPA. (RS)-AMPA hydrochloride is a glutamate analogue and a potent, selective agonist of the excitatory neurotransmitter L-glutamic acid. (RS)-AMPA hydrochloride does not interfere with the binding sites of kainate or NMDA receptors. | |||||||||||||||||||||
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Cl-HIBO | 99.0% | Cl-HIBO is a highly subtype-selective GluR1/2 agonist (EC50=4.7 and 1.7 μM, respectively). Cl-HIBO is a potent AMPA receptor agonist (IC50=0.22 μM). Cl-HIBO has desensitizing properties. | ||||||||||||||||||||
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TAN 950A | TAN 950A is antifungal amino acid antibiotic. TAN 950A has affinity for three excitatory amino acid (EAA) receptor and can inhibit [3H]AMPA, [3H]kainite and [3H]CPP binding competitively. TAN 950A can be used for the researches of infection and neurological disease. | |||||||||||||||||||||
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L-Ibotenic acid | L-Ibotenic acid is a psychoactive compound found in Amanita muscaria and related mushroom species. L-Ibotenic acid is a conformationally restricted analog of the neurotransmitter glutamate, which may be activated by different conformations of L-glutamate and is a non-selective glutamate receptor agonist. | |||||||||||||||||||||
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D-2-Thiolhistidine | D-2-Thiolhistidine can be used for modification of proteins and peptides. | |||||||||||||||||||||
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Ibotenic acid (Standard) | 99.39% | Ibotenic acid (Standard) ((RS)-Ibotenic acid (Standard)) is the analytical standard of Ibotenic acid (HY-N2311). This product is intended for research and analytical applications. Ibotenic acid has agonist activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Qm) receptor sites. | ||||||||||||||||||||
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References
- [1]. J A Larm, et al. (S)-5-fluorowillardiine-mediated neurotoxicity in cultured murine cortical neurones occurs via AMPA and kainate receptors. Eur J Pharmacol. 1996 Oct 24;314(1-2):249-54. [Content Brief]
- [2]. B Ebert, et al. Molecular pharmacology of the AMPA agonist, (S)-2-amino-3-(3-hydroxy-5-phenyl-4-isoxazolyl)propionic acid [(S)-APPA] and the AMPA antagonist, (R)-APPA. Neurochem Int. 1994 Jun;24(6):507-15. [Content Brief]
