Cl-HIBO
Based on 1 Customer Validation
Cl-HIBO is a highly subtype-selective GluR1/2 agonist (EC50=4.7 and 1.7 μM, respectively). Cl-HIBO is a potent AMPA receptor agonist (IC50=0.22 μM). Cl-HIBO has desensitizing properties.
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 909400-43-7
- Formula: C6H7ClN2O4
- Molecular Weight:206.58
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
EC50: 4.7, 1.7, 2700 and 1300 μM=GluR1/2/3/4[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Oocyte | EC50 |
1.7 μM
Compound: 3 (Cl-HIBO)
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Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 2 (GluR2) using rat cortical slice model in Xenopus laevis oocytes
Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 2 (GluR2) using rat cortical slice model in Xenopus laevis oocytes
|
[PMID: 12747796] |
| Oocyte | EC50 |
1.7 μM
Compound: 3, Cl-HIBO
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Agonist activity at rat recombinant GluA2(Q)i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay
Agonist activity at rat recombinant GluA2(Q)i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay
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[PMID: 21067182] |
| Oocyte | EC50 |
1.7 μM
Compound: Cl-HIBO
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Agonist activity at recombinant GluA2 receptor flop isoform expressed in Xenopus oocytes
Agonist activity at recombinant GluA2 receptor flop isoform expressed in Xenopus oocytes
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[PMID: 20096591] |
| Oocyte | EC50 |
1300 μM
Compound: 3 (Cl-HIBO)
|
Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 4 (GluR4) using rat cortical slice model in Xenopus laevis oocytes
Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 4 (GluR4) using rat cortical slice model in Xenopus laevis oocytes
|
[PMID: 12747796] |
| Oocyte | EC50 |
1300 μM
Compound: 3, Cl-HIBO
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Agonist activity at rat recombinant GluA4i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay
Agonist activity at rat recombinant GluA4i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay
|
[PMID: 21067182] |
| Oocyte | EC50 |
1300 μM
Compound: Cl-HIBO
|
Agonist activity at recombinant GluA4 receptor flip isoform expressed in Xenopus oocytes
Agonist activity at recombinant GluA4 receptor flip isoform expressed in Xenopus oocytes
|
[PMID: 20096591] |
| Oocyte | EC50 |
2700 μM
Compound: 3 (Cl-HIBO)
|
Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 3 (GluR3) using rat cortical slice model in Xenopus laevis oocytes
Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 3 (GluR3) using rat cortical slice model in Xenopus laevis oocytes
|
[PMID: 12747796] |
| Oocyte | EC50 |
2700 μM
Compound: 3, Cl-HIBO
|
Agonist activity at rat recombinant GluA3i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay
Agonist activity at rat recombinant GluA3i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay
|
[PMID: 21067182] |
| Oocyte | EC50 |
2700 μM
Compound: Cl-HIBO
|
Agonist activity at recombinant GluA3 receptor flip isoform expressed in Xenopus oocytes
Agonist activity at recombinant GluA3 receptor flip isoform expressed in Xenopus oocytes
|
[PMID: 20096591] |
| Oocyte | EC50 |
4.7 μM
Compound: 3 (Cl-HIBO)
|
Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 1 (GluR1) using rat cortical slice model in Xenopus laevis oocytes
Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 1 (GluR1) using rat cortical slice model in Xenopus laevis oocytes
|
[PMID: 12747796] |
| Oocyte | EC50 |
4.7 μM
Compound: 3, Cl-HIBO
|
Agonist activity at rat recombinant GluA1i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay
Agonist activity at rat recombinant GluA1i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay
|
[PMID: 21067182] |
| Oocyte | EC50 |
4.7 μM
Compound: Cl-HIBO
|
Agonist activity at recombinant GluA1 receptor flip isoform expressed in Xenopus oocytes
Agonist activity at recombinant GluA1 receptor flip isoform expressed in Xenopus oocytes
|
[PMID: 20096591] |
Cl-HIBO is a strongly desensitizing full agonist at GluR1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 909400-43-7
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Appearance Solid
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Molecular Weight 206.58
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Formula C6H7ClN2O4
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Color Light brown to gray
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SMILES
O=C(O)C(N)CC(ON1)=C(Cl)C1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 4.5 mg/mL (21.78 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.8407 mL | 24.2037 mL | 48.4074 mL | 121.0185 mL |
| 5 mM | 0.9681 mL | 4.8407 mL | 9.6815 mL | 24.2037 mL | |
| 10 mM | 0.4841 mL | 2.4204 mL | 4.8407 mL | 12.1018 mL | |
| 15 mM | 0.3227 mL | 1.6136 mL | 3.2272 mL | 8.0679 mL | |
| 20 mM | 0.2420 mL | 1.2102 mL | 2.4204 mL | 6.0509 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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