2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. L-Ibotenic acid

L-Ibotenic acid is a psychoactive compound found in Amanita muscaria and related mushroom species. L-Ibotenic acid is a conformationally restricted analog of the neurotransmitter glutamate, which may be activated by different conformations of L-glutamate and is a non-selective glutamate receptor agonist.

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L-Ibotenic acid

L-Ibotenic acid Chemical Structure

CAS No. : 25690-45-3

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L-Ibotenic acid Related Antibodies

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Description

L-Ibotenic acid is a psychoactive compound found in Amanita muscaria and related mushroom species. L-Ibotenic acid is a conformationally restricted analog of the neurotransmitter glutamate, which may be activated by different conformations of L-glutamate and is a non-selective glutamate receptor agonist[1].

Cellular Effect
Cell Line Type Value Description References
CHO EC50
110 μM
Compound: ibotenic acid
Activity at rat cloned mGluR2 expressed in CHO cells assessed as effect on cAMP accumulation
Activity at rat cloned mGluR2 expressed in CHO cells assessed as effect on cAMP accumulation
[PMID: 18338843]
CHO EC50
43 μM
Compound: ibotenic acid
Activity at rat cloned mGluR1a expressed in CHO cells assessed as effect on cAMP accumulation
Activity at rat cloned mGluR1a expressed in CHO cells assessed as effect on cAMP accumulation
[PMID: 18338843]
CHO EC50
> 1000 μM
Compound: ibotenic acid
Activity at rat cloned mGluR4 expressed in CHO cells assessed as effect on cAMP accumulation
Activity at rat cloned mGluR4 expressed in CHO cells assessed as effect on cAMP accumulation
[PMID: 18338843]
HEK293 EC50
> 1000 μM
Compound: ibotenic acid
Activity at rat cloned iGluR1 expressed in human HEK293 cells by calcium imaging assay
Activity at rat cloned iGluR1 expressed in human HEK293 cells by calcium imaging assay
[PMID: 18338843]
HEK293 EC50
> 1000 μM
Compound: ibotenic acid
Activity at rat cloned iGluR2 expressed in human HEK293 cells by calcium imaging assay
Activity at rat cloned iGluR2 expressed in human HEK293 cells by calcium imaging assay
[PMID: 18338843]
HEK293 EC50
> 1000 μM
Compound: ibotenic acid
Activity at rat cloned iGluR3 expressed in human HEK293 cells by calcium imaging assay
Activity at rat cloned iGluR3 expressed in human HEK293 cells by calcium imaging assay
[PMID: 18338843]
HEK293 EC50
> 1000 μM
Compound: ibotenic acid
Activity at rat cloned iGluR4 expressed in human HEK293 cells by calcium imaging assay
Activity at rat cloned iGluR4 expressed in human HEK293 cells by calcium imaging assay
[PMID: 18338843]
HEK293 EC50
> 1000 μM
Compound: ibotenic acid
Activity at rat cloned iGluR5 expressed in human HEK293 cells by calcium imaging assay
Activity at rat cloned iGluR5 expressed in human HEK293 cells by calcium imaging assay
[PMID: 18338843]
HEK293 EC50
> 1000 μM
Compound: ibotenic acid
Activity at rat cloned iGluR6 expressed in human HEK293 cells by calcium imaging assay
Activity at rat cloned iGluR6 expressed in human HEK293 cells by calcium imaging assay
[PMID: 18338843]
Molecular Weight

158.11

Formula

C5H6N2O4
CAS No.
SMILES

OC([C@H](C(ON1)=CC1=O)N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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L-Ibotenic acid Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Ibotenic acid25690-45-3iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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