L-Ibotenic acid
L-Ibotenic acid is a psychoactive compound found in Amanita muscaria and related mushroom species. L-Ibotenic acid is a conformationally restricted analog of the neurotransmitter glutamate, which may be activated by different conformations of L-glutamate and is a non-selective glutamate receptor agonist.
For research use only. We do not sell to patients.
- CAS No.: 25690-45-3
- Formula: C5H6N2O4
- Molecular Weight:158.11
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All iGluR Isoforms
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Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
110 μM
Compound: ibotenic acid
|
Activity at rat cloned mGluR2 expressed in CHO cells assessed as effect on cAMP accumulation
Activity at rat cloned mGluR2 expressed in CHO cells assessed as effect on cAMP accumulation
|
[PMID: 18338843] |
| CHO | EC50 |
43 μM
Compound: ibotenic acid
|
Activity at rat cloned mGluR1a expressed in CHO cells assessed as effect on cAMP accumulation
Activity at rat cloned mGluR1a expressed in CHO cells assessed as effect on cAMP accumulation
|
[PMID: 18338843] |
| CHO | EC50 |
>1000 μM
Compound: ibotenic acid
|
Activity at rat cloned mGluR4 expressed in CHO cells assessed as effect on cAMP accumulation
Activity at rat cloned mGluR4 expressed in CHO cells assessed as effect on cAMP accumulation
|
[PMID: 18338843] |
| HEK293 | EC50 |
>1000 μM
Compound: ibotenic acid
|
Activity at rat cloned iGluR2 expressed in human HEK293 cells by calcium imaging assay
Activity at rat cloned iGluR2 expressed in human HEK293 cells by calcium imaging assay
|
[PMID: 18338843] |
| HEK293 | EC50 |
>1000 μM
Compound: ibotenic acid
|
Activity at rat cloned iGluR3 expressed in human HEK293 cells by calcium imaging assay
Activity at rat cloned iGluR3 expressed in human HEK293 cells by calcium imaging assay
|
[PMID: 18338843] |
| HEK293 | EC50 |
>1000 μM
Compound: ibotenic acid
|
Activity at rat cloned iGluR4 expressed in human HEK293 cells by calcium imaging assay
Activity at rat cloned iGluR4 expressed in human HEK293 cells by calcium imaging assay
|
[PMID: 18338843] |
| HEK293 | EC50 |
>1000 μM
Compound: ibotenic acid
|
Activity at rat cloned iGluR5 expressed in human HEK293 cells by calcium imaging assay
Activity at rat cloned iGluR5 expressed in human HEK293 cells by calcium imaging assay
|
[PMID: 18338843] |
| HEK293 | EC50 |
>1000 μM
Compound: ibotenic acid
|
Activity at rat cloned iGluR6 expressed in human HEK293 cells by calcium imaging assay
Activity at rat cloned iGluR6 expressed in human HEK293 cells by calcium imaging assay
|
[PMID: 18338843] |
| HEK293 | EC50 |
>1000 μM
Compound: ibotenic acid
|
Activity at rat cloned iGluR1 expressed in human HEK293 cells by calcium imaging assay
Activity at rat cloned iGluR1 expressed in human HEK293 cells by calcium imaging assay
|
[PMID: 18338843] |
Chemical Information
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CAS No. 25690-45-3
-
Molecular Weight 158.11
-
Formula C5H6N2O4
-
SMILES
OC([C@H](C(ON1)=CC1=O)N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)