(S)-(+)-Dimethindene maleate (Standard)

製品番号: HY-107647R: Data Sheet 取扱説明書
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(S)-(+)-Dimethindene maleate (Standard) is the analytical standard of (S)-(+)-Dimethindene (maleate) (HY-107647). This product is intended for research and analytical applications. (S)-(+)-Dimethindene maleate, an enantiomer, is a potent M2-selective muscarinic receptor antagonist (pA2 = 7.86/7.74; pK_i = 7.78). (S)-(+)-Dimethindene maleate shows lower affinities for the muscarinic M1 (pA2 = 6.83/6.36; pK_i = 7.08), the M3 (pA2 = 6.92/6.96; pK_i = 6.70) and the M4 receptors (pK_i = 7.00), respectively. (S)-(+)-Dimethindene maleate also is a histamine H1 receptor antagonist (pA2 = 7.48).

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(S)-(+)-Dimethindene maleate (Standard) 構造式

CAS 番号 : 136152-65-3

容量		在庫状況
MOQ		Minimum order quantity
50 mg		お問い合わせ
100 mg		お問い合わせ
250 mg		お問い合わせ
Other size		お問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

mAChR アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

Histamine Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Histamine Receptor

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純度とドキュメンテーション
参考文献
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製品説明	(S)-(+)-Dimethindene maleate (Standard) is the analytical standard of (S)-(+)-Dimethindene (maleate) (HY-107647). This product is intended for research and analytical applications. (S)-(+)-Dimethindene maleate, an enantiomer, is a potent M2-selective muscarinic receptor antagonist (pA2 = 7.86/7.74; pK_i = 7.78). (S)-(+)-Dimethindene maleate shows lower affinities for the muscarinic M1 (pA2 = 6.83/6.36; pK_i = 7.08), the M3 (pA2 = 6.92/6.96; pK_i = 6.70) and the M4 receptors (pK_i = 7.00), respectively. (S)-(+)-Dimethindene maleate also is a histamine H1 receptor antagonist (pA2 = 7.48)^[1].
IC₅₀ & Target	pKi: 7.08 (M1), 7.78 (M2), 6.7(M3), 7(M4)
分子量	408.49
分子式	C₂₄H₂₈N₂O₄
CAS 番号	136152-65-3
SMILES	C[C@@H](C1=C(CCN(C)C)CC2=C1C=CC=C2)C3=NC=CC=C3.OC(/C=C\C(O)=O)=O
輸送条件	Room temperature in continental US; may vary elsewhere.
保管条件	Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション	データシート (274 KB) 取扱説明書 (2659 KB)
参考文献	[1]. Pfaff O, et al. The (S)-(+)-enantiomer of dimethindene: a novel M2-selective muscarinic receptor antagonist. Eur J Pharmacol. 1995;286(3):229-240. [Content Brief] [2]. Yang Y, et al. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. Cell. 2017;169(2):243-257.e25. [Content Brief]