1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR
  3. (S)-(+)-Dimethindene maleate

(S)-(+)-Dimethindene maleate 

Cat. No.: HY-107647
Handling Instructions

(S)-(+)-Dimethindene maleate, an enantiomer, is a potent M2-selective muscarinic receptor antagonist (pA2 = 7.86/7.74; pKi = 7.78). (S)-(+)-Dimethindene maleate shows lower affinities for the muscarinic M1 (pA2 = 6.83/6.36; pKi = 7.08), the M3 (pA2 = 6.92/6.96; pKi = 6.70) and the M4 receptors (pKi = 7.00), respectively. (S)-(+)-Dimethindene maleate also is a histamine H1 receptor antagonist (pA2 = 7.8).

For research use only. We do not sell to patients.

(S)-(+)-Dimethindene maleate Chemical Structure

(S)-(+)-Dimethindene maleate Chemical Structure

CAS No. : 136152-65-3

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Description

(S)-(+)-Dimethindene maleate, an enantiomer, is a potent M2-selective muscarinic receptor antagonist (pA2 = 7.86/7.74; pKi = 7.78). (S)-(+)-Dimethindene maleate shows lower affinities for the muscarinic M1 (pA2 = 6.83/6.36; pKi = 7.08), the M3 (pA2 = 6.92/6.96; pKi = 6.70) and the M4 receptors (pKi = 7.00), respectively. (S)-(+)-Dimethindene maleate also is a histamine H1 receptor antagonist (pA2 = 7.8)[1].

IC50 & Target

pKi: 7.08 (M1), 7.78 (M2), 6.7(M3), 7(M4)

In Vitro

(S)-(+)-Dimethinden is an important regulator in the maintenance of EPS cell developmental potency[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability AssayWB[2]

Cell Line: EPS cells
Concentration: 2 μM
Incubation Time: 1 hour
Result: Important regulator in the maintenance of EPS cell developmental potency.
In Vivo

(S)-(+)-Dimethindene maleate shows affinity profile at muscarinic M1 (NB-OK 1 cells), M2 (rat heart), M3 (rat pancreas) and M4 receptors (rat striatum), with pKis 7.08, 7.78, 6.7 and 7,respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

408.49

Formula

C₂₄H₂₈N₂O₄

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
(S)-(+)-Dimethindene maleate
Cat. No.:
HY-107647
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