1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. mAChR
    Histamine Receptor
  3. (S)-(+)-Dimethindene maleate

(S)-(+)-Dimethindene maleate 

Cat. No.: HY-107647 Purity: ≥99.0%
COA Handling Instructions

(S)-(+)-Dimethindene maleate, an enantiomer, is a potent M2-selective muscarinic receptor antagonist (pA2 = 7.86/7.74; pKi = 7.78). (S)-(+)-Dimethindene maleate shows lower affinities for the muscarinic M1 (pA2 = 6.83/6.36; pKi = 7.08), the M3 (pA2 = 6.92/6.96; pKi = 6.70) and the M4 receptors (pKi = 7.00), respectively. (S)-(+)-Dimethindene maleate also is a histamine H1 receptor antagonist (pA2 = 7.48).

For research use only. We do not sell to patients.

(S)-(+)-Dimethindene maleate Chemical Structure

(S)-(+)-Dimethindene maleate Chemical Structure

CAS No. : 136152-65-3

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Based on 1 publication(s) in Google Scholar

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Description

(S)-(+)-Dimethindene maleate, an enantiomer, is a potent M2-selective muscarinic receptor antagonist (pA2 = 7.86/7.74; pKi = 7.78). (S)-(+)-Dimethindene maleate shows lower affinities for the muscarinic M1 (pA2 = 6.83/6.36; pKi = 7.08), the M3 (pA2 = 6.92/6.96; pKi = 6.70) and the M4 receptors (pKi = 7.00), respectively. (S)-(+)-Dimethindene maleate also is a histamine H1 receptor antagonist (pA2 = 7.48)[1].

IC50 & Target[1]

mAChR2

7.78 (pKi)

mAChR1

7.08 (pKi)

mAChR4

7.00 (pKi)

mAChR3

6.70 (pKi)

H1 Receptor

7.48 (pA2)

In Vitro

(S)-(+)-Dimethindene maleate (2 μM; 1 h) significantly impaires the developmental potency of mouse extended pluripotent stem (mEPS) cells in chimeric blastocysts and leads to rapid differentiation of primed human pluripotent stem cell (hPSC)-converted hEPS cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Mouse EPS cells
Concentration: 2 μM
Incubation Time: 1 hour
Result: Significantly impaired the developmental potency of mEPS cells.
Molecular Weight

408.49

Formula

C24H28N2O4

CAS No.
SMILES

C[[email protected]@H](C1=C(CCN(C)C)CC2=C1C=CC=C2)C3=NC=CC=C3.OC(/C=C\C(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: ≥99.0%

References
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(S)-(+)-Dimethindene maleate
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HY-107647
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