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Cat. No.: HY-107647R

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(S)-(+)-Dimethindene maleate (Standard)

(S)-(+)-Dimethindene maleate (Standard) is the analytical standard of (S)-(+)-Dimethindene (maleate) (HY-107647). This product is intended for research and analytical applications. (S)-(+)-Dimethindene maleate, an enantiomer, is a potent M2-selective muscarinic receptor antagonist (pA2 = 7.86/7.74; pK_i = 7.78). (S)-(+)-Dimethindene maleate shows lower affinities for the muscarinic M1 (pA2 = 6.83/6.36; pK_i = 7.08), the M3 (pA2 = 6.92/6.96; pK_i = 6.70) and the M4 receptors (pK_i = 7.00), respectively. (S)-(+)-Dimethindene maleate also is a histamine H1 receptor antagonist (pA2 = 7.48).

For research use only. We do not sell to patients.

CAS No.: 136152-65-3
Formula: C₂₄H₂₈N₂O₄
Molecular Weight:408.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(S)-(+)-Dimethindene maleate (Standard) Chemical Structure

CAS No.: 136152-65-3

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- IC₅₀ & Target
Chemical Information
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Biological Activity

Description

IC₅₀ & Target

pKi: 7.08 (M1), 7.78 (M2), 6.7(M3), 7(M4)

All mAChR Isoforms :

All Histamine Receptor Isoforms :

Chemical Information

CAS No. 136152-65-3
Molecular Weight 408.49
Formula C₂₄H₂₈N₂O₄
SMILES

C[C@@H](C1=C(CCN(C)C)CC2=C1C=CC=C2)C3=NC=CC=C3.OC(/C=C\C(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Pfaff O, et al. The (S)-(+)-enantiomer of dimethindene: a novel M2-selective muscarinic receptor antagonist. Eur J Pharmacol. 1995;286(3):229-240. [Content Brief]

[2]. Yang Y, et al. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. Cell. 2017;169(2):243-257.e25. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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(S)-(+)-Dimethindene maleate (Standard)

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Biological Activity
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(S)-(+)-Dimethindene maleate (Standard)

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