2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Arecaidine but-2-ynyl ester tosylate

Arecaidine but-2-ynyl ester tosylate  (Synonyms: ABET)

Art. -Nr.: HY-107655 Reinheit: 99.76%
COA
SDS
Handling Instructions Technical Support

Arecaidine but-2-ynyl ester tosylate (ABET) is a selective mAChR M2 agonist that dose-dependently decreases mean arterial pressure and heart rate in rats. Arecaidine but-2-ynyl ester tosylate can be used for cardiovascular disease research. Arecaidine but-2-ynyl ester (tosylate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Arecaidine but-2-ynyl ester tosylate

Arecaidine but-2-ynyl ester tosylate Chemische Struktur

CAS. Nr. : 119630-77-2

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Based on 1 publication(s) in Google Scholar

Arecaidine but-2-ynyl ester tosylate Related Antibodies

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Alle mAChR Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

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Beschreibung

Arecaidine but-2-ynyl ester tosylate (ABET) is a selective mAChR M2 agonist that dose-dependently decreases mean arterial pressure and heart rate in rats. Arecaidine but-2-ynyl ester tosylate can be used for cardiovascular disease research[1][2]. Arecaidine but-2-ynyl ester (tosylate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Molekulargewicht

365.44

Formel

C18H23NO5S
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

CC#CCOC(C1=CCCN(C)C1)=O.O=S(O)(C2=CC=C(C)C=C2)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 125 mg/mL (342.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7364 mL 13.6821 mL 27.3643 mL
5 mM 0.5473 mL 2.7364 mL 5.4729 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation

Purity: 99.76%

SDS (393 KB)

COA (251 KB) HNMR (281 KB) LCMS (341 KB)

Handling Instructions (2659 KB)
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7364 mL 13.6821 mL 27.3643 mL 68.4107 mL
5 mM 0.5473 mL 2.7364 mL 5.4729 mL 13.6821 mL
10 mM 0.2736 mL 1.3682 mL 2.7364 mL 6.8411 mL
15 mM 0.1824 mL 0.9121 mL 1.8243 mL 4.5607 mL
20 mM 0.1368 mL 0.6841 mL 1.3682 mL 3.4205 mL
25 mM 0.1095 mL 0.5473 mL 1.0946 mL 2.7364 mL
30 mM 0.0912 mL 0.4561 mL 0.9121 mL 2.2804 mL
40 mM 0.0684 mL 0.3421 mL 0.6841 mL 1.7103 mL
50 mM 0.0547 mL 0.2736 mL 0.5473 mL 1.3682 mL
60 mM 0.0456 mL 0.2280 mL 0.4561 mL 1.1402 mL
80 mM 0.0342 mL 0.1710 mL 0.3421 mL 0.8551 mL
100 mM 0.0274 mL 0.1368 mL 0.2736 mL 0.6841 mL
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Arecaidine but-2-ynyl ester tosylate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Arecaidine but-2-ynyl ester119630-77-2ABETmAChRMuscarinic acetylcholine receptorcardiovascular diseaseheart ratearterial pressureInhibitorinhibitorinhibit

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