2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Nitrocaramiphen hydrochloride

Nitrocaramiphen hydrochloride is a selective M1 receptor antagonist (Ki: 5.5 nM). Nitrocaramiphen Hydrochloride inhibits the hyperpolarizing effect of muscarine in the muscle fibers.

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Nitrocaramiphen hydrochloride Chemical Structure

Nitrocaramiphen hydrochloride Chemical Structure

CAS No. : 98636-73-8

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Based on 1 publication(s) in Google Scholar

Nitrocaramiphen hydrochloride Related Antibodies

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Description

Nitrocaramiphen hydrochloride is a selective M1 receptor antagonist (Ki: 5.5 nM). Nitrocaramiphen Hydrochloride inhibits the hyperpolarizing effect of muscarine in the muscle fibers[1][2][3].

IC50 & Target

Ki: 5.5 nM (M1 receptor)[2]
Molecular Weight

370.87

Formula

C18H27ClN2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1(C2=CC=C([N+]([O-])=O)C=C2)CCCC1)OCCN(CC)CC.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (26.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 8.33 mg/mL (22.46 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6964 mL 13.4818 mL 26.9636 mL
5 mM 0.5393 mL 2.6964 mL 5.3927 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.6964 mL 13.4818 mL 26.9636 mL 67.4091 mL
5 mM 0.5393 mL 2.6964 mL 5.3927 mL 13.4818 mL
10 mM 0.2696 mL 1.3482 mL 2.6964 mL 6.7409 mL
15 mM 0.1798 mL 0.8988 mL 1.7976 mL 4.4939 mL
20 mM 0.1348 mL 0.6741 mL 1.3482 mL 3.3705 mL
DMSO 25 mM 0.1079 mL 0.5393 mL 1.0785 mL 2.6964 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Nitrocaramiphen hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nitrocaramiphen98636-73-8mAChRMuscarinic acetylcholine receptorM1 receptorhyperpolarizemuscarinemuscle fiberInhibitorinhibitorinhibit

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