Nitrocaramiphen hydrochloride
Based on 1 Customer Validation
Nitrocaramiphen hydrochloride is a selective M1 receptor antagonist (Ki: 5.5 nM). Nitrocaramiphen Hydrochloride inhibits the hyperpolarizing effect of muscarine in the muscle fibers.
For research use only. We do not sell to patients.
- Purity: 98.01%
- CAS No.: 98636-73-8
- Formula: C18H27ClN2O4
- Molecular Weight:370.87
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Ki: 5.5 nM (M1 receptor)[2]
Chemical Information
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CAS No. 98636-73-8
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Appearance Solid
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Molecular Weight 370.87
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Formula C18H27ClN2O4
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Color White to off-white
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SMILES
O=C(C1(C2=CC=C([N+]([O-])=O)C=C2)CCCC1)OCCN(CC)CC.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 10 mg/mL (26.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 8.33 mg/mL (22.46 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Hussain RI, et al. Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation. Br J Pharmacol. 2009 Feb;156(4):575-86. [Content Brief]
[2]. Hudkins RL, et al. Caramiphen, iodocaramiphen and nitrocaramiphen are potent, competitive, muscarinic M1 receptor-selective agents. Eur J Pharmacol. 1993 Feb 16;231(3):485-8. [Content Brief]
[3]. Naumenko NV, et al. [Pharmacological parameters of muscarinic cholinoreceptors in skeletal muscles]. Ross Fiziol Zh Im I M Sechenova. 2002 May;88(5):619-26. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.6964 mL | 13.4818 mL | 26.9636 mL | 67.4091 mL |
| 5 mM | 0.5393 mL | 2.6964 mL | 5.3927 mL | 13.4818 mL | |
| 10 mM | 0.2696 mL | 1.3482 mL | 2.6964 mL | 6.7409 mL | |
| 15 mM | 0.1798 mL | 0.8988 mL | 1.7976 mL | 4.4939 mL | |
| 20 mM | 0.1348 mL | 0.6741 mL | 1.3482 mL | 3.3705 mL | |
| DMSO | 25 mM | 0.1079 mL | 0.5393 mL | 1.0785 mL | 2.6964 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Nitrocaramiphen hydrochloride Related Classifications
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