Cat. No.: HY-13710

Dimethindene

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Dimethindene is a potent, selective histamine H1 antagonist. Dimethindene impairs cutaneous wound healing (WH). Dimethindene can block K⁺ currents.

For research use only. We do not sell to patients.

Purity: 98.94%
CAS No.: 5636-83-9
Formula: C₂₀H₂₄N₂
Molecular Weight:292.42

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Dimethindene Chemical Structure

CAS No.: 5636-83-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Dimethindene is a potent, selective histamine H1 antagonist. Dimethindene impairs cutaneous wound healing (WH). Dimethindene can block K⁺ currents^[1]^[2].

All Histamine Receptor Isoforms :

All Endogenous Metabolite Isoforms :

In Vitro

Dimethindene (5-500 μM; follicle-enclosed Xenopus oocytes) decreases Cromakalim cromakalim-induced K⁺ currents with an IC₅₀ value of 29.5 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dimethindene (0.25 mg; i.p.; once; C57BL/6 mice with skin WH) impaires cutaneous wound healing (WH) and delays skin wound closure^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 mice with skin WH^[1]
Dosage:

0.25 mg
Administration:

intraperitoneal injection; once
Result:

Delayed skin wound closure as compared to vehicle treated mice.

Chemical Information

CAS No. 5636-83-9
Appearance Solid
Molecular Weight 292.42
Formula C₂₀H₂₄N₂
Color Light yellow to yellow
SMILES

CC(C1=C(CCN(C)C)CC2=C1C=CC=C2)C3=NC=CC=C3
Structure Classification
- Alkaloids
- Pyridine Alkaloids
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (427.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

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Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.4197 mL

17.0987 mL

34.1974 mL

5 mM

0.6839 mL

3.4197 mL

6.8395 mL

10 mM

0.3420 mL

1.7099 mL

3.4197 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Weller K, et, al. Mast cells are required for normal healing of skin wounds in mice. FASEB J. 2006 Nov;20(13):2366-8. [Content Brief]

[2]. Sakuta H. Inhibition by histamine H1 receptor antagonists of endogenous glibenclamide-sensitive K+ channels in follicle-enclosed Xenopus oocytes. Eur J Pharmacol. 1994 Jan 1;266(1):99-102. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.4197 mL	17.0987 mL	34.1974 mL	85.4935 mL
	5 mM	0.6839 mL	3.4197 mL	6.8395 mL	17.0987 mL
	10 mM	0.3420 mL	1.7099 mL	3.4197 mL	8.5493 mL
	15 mM	0.2280 mL	1.1399 mL	2.2798 mL	5.6996 mL
	20 mM	0.1710 mL	0.8549 mL	1.7099 mL	4.2747 mL
	25 mM	0.1368 mL	0.6839 mL	1.3679 mL	3.4197 mL
	30 mM	0.1140 mL	0.5700 mL	1.1399 mL	2.8498 mL
	40 mM	0.0855 mL	0.4275 mL	0.8549 mL	2.1373 mL
	50 mM	0.0684 mL	0.3420 mL	0.6839 mL	1.7099 mL
	60 mM	0.0570 mL	0.2850 mL	0.5700 mL	1.4249 mL
	80 mM	0.0427 mL	0.2137 mL	0.4275 mL	1.0687 mL
	100 mM	0.0342 mL	0.1710 mL	0.3420 mL	0.8549 mL

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Dimethindene

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All Histamine Receptor Isoforms

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Dimethindene Related Classifications

HY-13710 Related Classifications