Dimethindene maleate

Cat. No.: HY-13710A Purity: 99.92%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Dimethindene maleate is a selective histamine H1 antagonist with antihistamine effects. Dimethindene maleate can be used for the research of hypersensitivity reactions.

For research use only. We do not sell to patients.

Dimethindene maleate Chemical Structure

CAS No. : 3614-69-5

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
5 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 190	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 640	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 980	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of Dimethindene maleate:

(S)-(+)-Dimethindene maleate In-stock
Dimethindene Get quote

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
Customer Review

Description

Dimethindene maleate is a selective histamine H1 antagonist with antihistamine effects. Dimethindene maleate can be used for the research of hypersensitivity reactions^[1]^[2]^[3].

IC₅₀ & Target

IC50: 29.5 μM (cromakalim-induced K^＋ currents), 49 μM (Y-26763-induced K^＋ currents)^[2]

In Vitro

Dimethindene maleate (1-1000 μM) suppresses the cromakalim-induced/glibenclamide-sensitive K^＋ currents in a concentration-dependent and reversible manner with an IC₅₀ value of 29.5 μM^[2].
Dimethindene maleate (1-1000 μM) inhibits Y-26763-induced glibenclamide-sensitive K^＋ currents with an IC₅₀ value of 49 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dimethindene maleate (0.25 mg; i.p. once) affects wound healing in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice with wound healing^[1]
Dosage:	0.25 mg
Administration:	Intraperitoneal injection; 0.25 mg once
Result:	Significantly delayed skin wound and only showed wound closure impairment in the initial phase wound healing.

Molecular Weight

408.49

Formula

C₂₄H₂₈N₂O₄

CAS No.

3614-69-5

Appearance

Solid

Color

White to off-white

SMILES

CC(C1=C(CCN(C)C)CC2=C1C=CC=C2)C3=NC=CC=C3.O=C(O)/C=C\C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (306.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4480 mL	12.2402 mL	24.4804 mL
5 mM	0.4896 mL	2.4480 mL	4.8961 mL
10 mM	0.2448 mL	1.2240 mL	2.4480 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.92%

Select Batch:

Data Sheet (279 KB) SDS (252 KB)

COA (257 KB) HNMR (289 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4480 mL	12.2402 mL	24.4804 mL	61.2010 mL
	5 mM	0.4896 mL	2.4480 mL	4.8961 mL	12.2402 mL
	10 mM	0.2448 mL	1.2240 mL	2.4480 mL	6.1201 mL
	15 mM	0.1632 mL	0.8160 mL	1.6320 mL	4.0801 mL
	20 mM	0.1224 mL	0.6120 mL	1.2240 mL	3.0601 mL
	25 mM	0.0979 mL	0.4896 mL	0.9792 mL	2.4480 mL
	30 mM	0.0816 mL	0.4080 mL	0.8160 mL	2.0400 mL
	40 mM	0.0612 mL	0.3060 mL	0.6120 mL	1.5300 mL
	50 mM	0.0490 mL	0.2448 mL	0.4896 mL	1.2240 mL
	60 mM	0.0408 mL	0.2040 mL	0.4080 mL	1.0200 mL
	80 mM	0.0306 mL	0.1530 mL	0.3060 mL	0.7650 mL
	100 mM	0.0245 mL	0.1224 mL	0.2448 mL	0.6120 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dimethindene3614-69-5Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks

Product Name			Lot #
Applicant Name *			Email Address *
Phone Number			Department *
Organization Name *			Country or Region *
Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

Dimethindene maleate

Other Forms of Dimethindene maleate: