Sclareol

Name: Sclareol
Brand: MedChemExpress
SKU: HY-N0128
Rating: 5.0 (3 reviews)

Cat. No.: HY-N0128 Purity: 99.84%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Sclareol is isolated from Salvia sclarea with anticarcinogenic activity. Sclareol shows strong cytotoxic activity against mouse leukemia (P-388), human epidermal carcinoma (KB) cells and human leukemia cell lines. Sclareol induces cell apoptosis.

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Sclareol 화학구조

CAS No. : 515-03-7

사이즈	재고	수량

무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 3 publication(s) in Google Scholar

Other Forms of Sclareol:

Sclareol (Standard) 견적 받기

3 Publications Citing Use of MCE Sclareol

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
순도&문서
References
고객리뷰

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3.21 3 Compound: 1	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 25825934]
A549	IC₅₀	3.21 3 Compound: 1	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 25825934]
A549	IC₅₀	3.21 3 Compound: 1	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 25825934]
B16	IC₅₀	28 6 Compound: 1	In vitro cytotoxicity of compound was measured on murine melanoma (B16) cells. In vitro cytotoxicity of compound was measured on murine melanoma (B16) cells.	[PMID: 9873721]
B16	IC₅₀	28 6 Compound: 1	In vitro cytotoxicity of compound was measured on murine melanoma (B16) cells. In vitro cytotoxicity of compound was measured on murine melanoma (B16) cells.	[PMID: 9873721]
HeLa	IC₅₀	3.35 3 Compound: 1	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 25825934]
Cancer cell lines	IC₅₀	7 6 Compound: 1, Sclareol	Cytotoxicity against human breast cancer cells Cytotoxicity against human breast cancer cells	[PMID: 22250858]
Cancer cell lines	IC₅₀	7 6 Compound: 1, Sclareol	Cytotoxicity against human breast cancer cells Cytotoxicity against human breast cancer cells	[PMID: 22250858]
HUVEC	IC₅₀	> 50 6 Compound: 4	Growth inhibitory activity against human umbilical vein endothelial cells (HUVEC) proliferation using MTT colorimetric method Growth inhibitory activity against human umbilical vein endothelial cells (HUVEC) proliferation using MTT colorimetric method	[PMID: 12781184]
HCT-116	IC₅₀	10.6 6 Compound: 1, Sclareol	Cytotoxicity against human HCT116 cells Cytotoxicity against human HCT116 cells	[PMID: 22250858]
HCT-116	IC₅₀	10.6 6 Compound: 1, Sclareol	Cytotoxicity against human HCT116 cells Cytotoxicity against human HCT116 cells	[PMID: 22250858]
PC-3	IC₅₀	0.105 3 Compound: 1	Cytotoxicity against human PC3 cells after 48 hrs by MTT assay Cytotoxicity against human PC3 cells after 48 hrs by MTT assay	[PMID: 25825934]
HUVEC	IC₅₀	> 50 6 Compound: 4	Growth inhibitory activity against human umbilical vein endothelial cells (HUVEC) proliferation using MTT colorimetric method Growth inhibitory activity against human umbilical vein endothelial cells (HUVEC) proliferation using MTT colorimetric method	[PMID: 12781184]
HeLa	IC₅₀	3.35 3 Compound: 1	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 25825934]
HeLa	IC₅₀	3.35 3 Compound: 1	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 25825934]
HUVEC	IC₅₀	>50 6 Compound: 4	Growth inhibitory activity against human umbilical vein endothelial cells (HUVEC) proliferation using MTT colorimetric method Growth inhibitory activity against human umbilical vein endothelial cells (HUVEC) proliferation using MTT colorimetric method	[PMID: 12781184]
Leukemia cell	IC₅₀	6 6 Compound: 1, Sclareol	Cytotoxicity against human leukemia cells Cytotoxicity against human leukemia cells	[PMID: 22250858]
Leukemia cell	IC₅₀	6 6 Compound: 1, Sclareol	Cytotoxicity against human leukemia cells Cytotoxicity against human leukemia cells	[PMID: 22250858]
P388	IC₅₀	10.1 6 Compound: 1	In vitro cytotoxicity of compound was measured on murine lymphocytic leukemia (P-388) cells. In vitro cytotoxicity of compound was measured on murine lymphocytic leukemia (P-388) cells.	[PMID: 9873721]
P388	IC₅₀	10.1 6 Compound: 1	In vitro cytotoxicity of compound was measured on murine lymphocytic leukemia (P-388) cells. In vitro cytotoxicity of compound was measured on murine lymphocytic leukemia (P-388) cells.	[PMID: 9873721]
PBMC	IC₅₀	10.7 6 Compound: 1, Sclareol	Cytotoxicity against human PBMC Cytotoxicity against human PBMC	[PMID: 22250858]
PBMC	IC₅₀	10.7 6 Compound: 1, Sclareol	Cytotoxicity against human PBMC Cytotoxicity against human PBMC	[PMID: 22250858]
PC-3	IC₅₀	0.105 3 Compound: 1	Cytotoxicity against human PC3 cells after 48 hrs by MTT assay Cytotoxicity against human PC3 cells after 48 hrs by MTT assay	[PMID: 25825934]
PC-3	IC₅₀	0.105 3 Compound: 1	Cytotoxicity against human PC3 cells after 48 hrs by MTT assay Cytotoxicity against human PC3 cells after 48 hrs by MTT assay	[PMID: 25825934]
SNU1	IC₅₀	11.9 6 Compound: 1	In vitro cytotoxicity of compound was measured on human gastric adenocarcinoma (SNU-1) cells. In vitro cytotoxicity of compound was measured on human gastric adenocarcinoma (SNU-1) cells.	[PMID: 9873721]
SNU1	IC₅₀	11.9 6 Compound: 1	In vitro cytotoxicity of compound was measured on human gastric adenocarcinoma (SNU-1) cells. In vitro cytotoxicity of compound was measured on human gastric adenocarcinoma (SNU-1) cells.	[PMID: 9873721]

In Vitro

Sclareol is cytotoxic to 13 of 14 human leukemia cell lines tested, with IC₅₀ values ranging from 6.0-24.2 μg/mL, but is not cytotoxic to peripheral blood mononuclear leukocytes within the same dose range^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

308.50

화학식

C₂₀H₃₆O₂

CAS No.

515-03-7

Appearance

Solid

Color

White to off-white

SMILES

CC1(C)CCC[C@@]2(C)[C@@]1([H])CC[C@](O)(C)[C@@H]2CC[C@@](C)(O)C=C

Structure Classification

Initial Source

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 100 mg/mL (324.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2415 mL	16.2075 mL	32.4149 mL
5 mM	0.6483 mL	3.2415 mL	6.4830 mL
10 mM	0.3241 mL	1.6207 mL	3.2415 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.10 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.10 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (8.10 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

순도&문서

Purity: 99.84%

Select Batch:

Data Sheet (276 KB) SDS (392 KB)

COA (256 KB) HNMR (250 KB) LCMS (85 KB)

Handling Instructions (2659 KB)

References

[1]. Robert Tisserand, et al. Sclareol.Constituent profiles

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2415 mL	16.2075 mL	32.4149 mL	81.0373 mL
	5 mM	0.6483 mL	3.2415 mL	6.4830 mL	16.2075 mL
	10 mM	0.3241 mL	1.6207 mL	3.2415 mL	8.1037 mL
	15 mM	0.2161 mL	1.0805 mL	2.1610 mL	5.4025 mL
	20 mM	0.1621 mL	0.8104 mL	1.6207 mL	4.0519 mL
	25 mM	0.1297 mL	0.6483 mL	1.2966 mL	3.2415 mL
	30 mM	0.1080 mL	0.5402 mL	1.0805 mL	2.7012 mL
	40 mM	0.0810 mL	0.4052 mL	0.8104 mL	2.0259 mL
	50 mM	0.0648 mL	0.3241 mL	0.6483 mL	1.6207 mL
	60 mM	0.0540 mL	0.2701 mL	0.5402 mL	1.3506 mL
	80 mM	0.0405 mL	0.2026 mL	0.4052 mL	1.0130 mL
	100 mM	0.0324 mL	0.1621 mL	0.3241 mL	0.8104 mL

Sclareol Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sclareol515-03-7Environmental PollutantsApoptosisEnvironmental ContaminantsSalvia sclarealeukemiaP-388human epidermal carcinoma cellapoptosisInhibitorinhibitorinhibit

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Sclareol

고객리뷰

Other Forms of Sclareol:

Sclareol Related Antibodies

3 Publications Citing Use of MCE Sclareol

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

순도&문서

References

고객리뷰

Sclareol Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

Sclareol Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report