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Ag egfr Inhibitors

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13524
    AG-1478
    45+ Cited Publications

    Tyrphostin Ag-1478; NSC 693255

    		 EGFR HCV Influenza Virus Infection Cardiovascular Disease Metabolic Disease Cancer
    AG-1478 (Tyrphostin AG-1478) is a selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM. AG-1478 has antiviral effects against HCV and encephalomyocarditis virus (EMCV).
    AG-1478
  • HY-12000
    AG490
    Maximum Cited Publications
    165 Publications Verification

    Tyrphostin Ag490; Tyrphostin B42

    		 EGFR STAT JAK Autophagy Cancer
    AG490 (Tyrphostin AG490) is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.
    AG490
  • HY-14346
    PD153035
    5+ Cited Publications

    SU-5271; Ag1517; ZM 252868

    		 EGFR Cancer
    PD153035 (SU-5271; AG1517; ZM 252868) is a potent EGFR inhibitor with Ki and IC50 of 6 and 25 pM, respectively.
    PD153035
  • HY-101042
    AG-494

    Tyrphostin Ag 494

    		 EGFR CDK Cancer
    AG-494 (Tyrphostin AG 494) is a potent and selective EGFR tyrosine kinase inhibitor (IC50=0.7 μM). AG-494 inhibits the autophosphorylation of EGFR, ErbB2, HER1-2 and PDGF-R with IC50s 1.1, 39, 45 and 6 μM, respectively. AG-494 blocks Cdk2 activation and inhibits EGF-dependent DNA synthesis .
    AG-494
  • HY-15336
    AG 555

    Tyrphostin Ag 555

    		 EGFR Reverse Transcriptase Cancer
    AG 555 (Tyrphostin AG 555), a potent antiretroviral agent, is a potent and selective inhibitor of EGFR and blocks Cdk2 activation .
    AG 555
  • HY-20878
    Tyrphostin AG 879
    3 Publications Verification

    Ag 879

    		 Trk Receptor EGFR Apoptosis Cancer
    Tyrphostin AG 879 (AG 879) is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation (IC50 of 10 μM), but not TrKB and TrKC. Tyrphostin AG 879 is also a selective ErbB2 tyrosine kinase inhibitor with an IC50 of 1 μM, and has at least 500-fold higher selectivity to ErbB2 than EGFR. Tyrphostin AG 879 has anticancer activity .
    Tyrphostin AG 879
  • HY-156041
    Lysophosphatidylethanolamines, egg

    Lyso-PE (egg); LPE (egg); L-α-lysophosphatidylethanolamine

    		 Endogenous Metabolite Metabolic Disease
    Lysophosphatidylethanolamine (LPE) is a naturally-occurring lysophospholipid that can be generated via deacylation of phosphatidylethanolamine by phospholipase A2 (PLA2). It increases the phosphorylation of ERK1/2 in PC12 cells, an effect that can be blocked by the MEK inhibitors U-0126 (HY-12031A) and PD 98059 (HY-12028) and the EGFR inhibitor AG-1478 (HY-13524).1 LPE also increases neurite outgrowth and expression of neurofilament M in PC12 cells. LPE inhibits the activity of phospholipase D (PLD) partially purified from cabbage.3 This product contains lysophosphatidylethanolamine molecular species with variable fatty acyl chain lengths at the sn-1 position and a hydroxy group at the sn-2 position.
    Lysophosphatidylethanolamines, egg
  • HY-112474
    Tyrphostin AG 112

    		EGFR Cancer
    Tyrphostin AG 112 is an EGFR phosphorylation inhibitor .
    Tyrphostin AG 112
  • HY-118532
    Tyrphostin AG30
    1 Publications Verification

    Ag30

    		 EGFR Cancer
    Tyrphostin AG30 (AG30) is a potent and selective EGFR tyrosine kinase inhibitor. Tyrphostin AG30 (AG30) selectively inhibits self renewal induction by c-ErbB, and is able to inhibit activation of STAT5 by c-ErbB in primary erythroblasts .
    Tyrphostin AG30
  • HY-100962
    (E)-AG 99
    1 Publications Verification

    (E)-Tyrphostin 46; (E)-Tyrphostin Ag 99

    		 EGFR Cancer
    (E)-AG 99 ((E)-Tyrphostin 46) is a potent EGFR inhibitor .
    (E)-AG 99
  • HY-100499
    Tyrphostin AG 528
    1 Publications Verification

    Tyrphostin B66; Ag 528

    		 EGFR Cancer
    Tyrphostin AG 528 is an inhibitor of EGFR and ErbB2 with IC50s of 4.9 and 2.1 μM, respectively. Tyrphostin AG 528 (Tyrphostin B66) is a protein tyrosine kinase inhibitor, with IC50s of 4.9 μM for epidermal growth factor receptors (EGFR) and 2.1 μM for ErbB2 . Tyrphostin AG 528 is also an anticancer agent .
    Tyrphostin AG 528
  • HY-12806
    AG1557

    		EGFR Cancer
    AG1557 is a specific and ATP competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, has a pIC50 value of 8.194 .
    AG1557
  • HY-108931
    AG 1406

    		EGFR Cancer
    AG 1406 (compound M19) is a HER2 inhibitor, with an IC50 of 10.57 μM for HER2 in BT474 cell and >50 μM for EGFR in EGF-3T3 cell .
    AG 1406
  • HY-13524A
    AG-1478 hydrochloride

    Tyrphostin Ag-1478 hydrochloride; NSC 693255 hydrochloride

    		 EGFR HCV Influenza Virus Infection Cardiovascular Disease Metabolic Disease Cancer
    AG-1478 hydrochloride (Tyrphostin AG-1478 hydrochloride) is a selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM. AG-1478 hydrochloride has antiviral effects against HCV and encephalomyocarditis virus (EMCV) .
    AG-1478 hydrochloride
  • HY-101041
    (E)-AG 556

    (E)-Tyrphostin Ag 556

    		 EGFR Inflammation/Immunology
    (E)-AG 556 is a highly selective EGFR inhibitor and also blocks LPS-induced TNF-α production .
    (E)-AG 556
  • HY-101958
    Tyrphostin 25

    Ag82; Tyrphostin A 25; Tyrphostin Ag 82; RG-50875

    		 EGFR GPR35 Inflammation/Immunology Cancer
    Tyrphostin 25 (AG82) is a specific inhibitor of the EGFR tyrosine kinase with an IC50 value of 3 µM in A431 cells. Tyrphostin 25 is also a GPR35 agonist with an EC50 of 5.3 µM .
    Tyrphostin 25
  • HY-107459
    (E/Z)-AG490
    1 Publications Verification

    (E/Z)-Tyrphostin Ag490; (E/Z)-Tyrphostin B42

    		 EGFR STAT JAK Cancer
    (E/Z)-AG490 ((E/Z)-Tyrphostin AG490) is a racemic compound of (E)-AG490 and (Z)-AG490 isomers. (E)-AG490 (HY-12000) is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.
    (E/Z)-AG490
  • HY-13524R
    AG-1478 (Standard)

    Tyrphostin Ag-1478 (Standard); NSC 693255 (Standard)

    		 EGFR HCV Influenza Virus Reference Standards Infection Cardiovascular Disease Metabolic Disease Cancer
    AG-1478 (Standard) is the analytical standard of AG-1478. This product is intended for research and analytical applications. AG-1478 (Tyrphostin AG-1478) is a selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM. AG-1478 has antiviral effects against HCV and encephalomyocarditis virus (EMCV).
    AG-1478 (Standard)
  • HY-120036
    Tyrphostin AG1112

    		Casein Kinase Tyrosinase Cancer
    Tyrphostin AG1112 is a potent inhibitors of CK II. Tyrphostin AG1112 inhibits p210 bcr-abl tyrosine kinase, with IC50 values of 2, 15, 20 μM in p210 bcr-abl, EGFR and PDGFR cells, respectively .
    Tyrphostin AG1112
  • HY-101959
    Tyrphostin AG213

    Ag213

    		 EGFR Topoisomerase Cancer
    Tyrphostin AG213 (AG213) is an inhibitor of epidermal growth factor receptor (EGFR) protein tyrosine kinase (IC50=0.85 μM). Tyrphostin AG213 inhibits tyrosine kinase activity IC50=2.4 μM) and topoisomerase II (IC100=50 μM). Tyrphostin AG213 can induce nonapoptotic cell programmed death in tumor cells .
    Tyrphostin AG213
  • HY-101958R
    Tyrphostin 25 (Standard)

    Ag82 (Standard); Tyrphostin A 25 (Standard); Tyrphostin Ag 82 (Standard); RG-50875 (Standard)

    		 Reference Standards EGFR GPR35 Inflammation/Immunology Cancer
    Tyrphostin 25 (Standard) (AG82 (Standard)) is the analytical standard of Tyrphostin 25 (HY-101958). This product is intended for research and analytical applications. Tyrphostin 25 (AG82) is a specific inhibitor of the EGFR tyrosine kinase with an IC50 value of 3 µM in A431 cells. Tyrphostin 25 is also a GPR35 agonist with an EC50 of 5.3 µM .
    Tyrphostin 25 (Standard)
  • HY-100962R
    (E)-AG 99 (Standard)

    (E)-Tyrphostin 46 (Standard); (E)-Tyrphostin Ag 99 (Standard)

    		 EGFR Reference Standards Cancer
    (E)-AG 99 (Standard) is the analytical standard of (E)-AG 99 (HY-100962). This product is intended for research and analytical applications. (E)-AG 99 ((E)-Tyrphostin 46) is a potent EGFR inhibitor .
    (E)-AG 99 (Standard)
  • HY-107459R
    (E/Z)-AG490 (Standard)

    (E/Z)-Tyrphostin Ag490 (Standard); (E/Z)-Tyrphostin B42 (Standard)

    		 Reference Standards EGFR STAT JAK Cancer
    (E/Z)-AG490 (Standard) is the analytical standard of (E/Z)-AG490 (HY-107459). This product is intended for research and analytical applications. (E/Z)-AG490 ((E/Z)-Tyrphostin AG490) is a racemic compound of (E)-AG490 and (Z)-AG490 isomers. (E)-AG490 (HY-12000) is a tyrosine Kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.
    (E/Z)-AG490 (Standard)

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