Cat. No.: HY-20878

Tyrphostin AG 879

(Synonyms: AG 879)

3 Cited Publications

Customer Review

Based on 3 publication(s) in Google Scholar

Tyrphostin AG 879 (AG 879) is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation (IC₅₀ of 10 μM), but not TrKB and TrKC. Tyrphostin AG 879 is also a selective ErbB2 tyrosine kinase inhibitor with an IC₅₀ of 1 μM, and has at least 500-fold higher selectivity to ErbB2 than EGFR. Tyrphostin AG 879 has anticancer activity.

For research use only. We do not sell to patients.

Purity: 99.26%
CAS No.: 148741-30-4
Formula: C₁₈H₂₄N₂OS
Molecular Weight:316.46

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Tyrphostin AG 879 Chemical Structure

CAS No.: 148741-30-4

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

TrkA

All Trk Receptor Isoforms :

All EGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	>81 μM Compound: 70; AG879	Cytotoxicity against human A549 cells Cytotoxicity against human A549 cells	[PMID: 33539089]
A549	IC₅₀	0.005 μM Compound: AG879	Growth inhibition of human A549 cells Growth inhibition of human A549 cells	[PMID: 28814374]

In Vitro

Tyrphostin AG 879 (0.5-50 μM; 48 hours; HL-60, U-937, PC-3, HTB-82, HTB-114, TE-671, HTB-115 and HTB-88 cells) treatment significantly and dose dependently decreases cell proliferation in all the cell lines^[1].
Tyrphostin AG 879 (0.5-50 μM; 48 hours; HL-60, U-937, PC-3, HTB-82, HTB-114, TE-671, HTB-115 and HTB-88 cells) treatment also induces a dose-dependent increase in apoptosis with the exception of the lines TE-671 and HTB-88 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

HL-60, U-937, PC-3, HTB-82, HTB-114, TE-671, HTB-115 and HTB-88 cells
Concentration:

0.5 μM, 5 μM, 20 μM and 50 μM
Incubation Time:

48 hours
Result:

Significantly and dose dependently decreased cell proliferation in all the cell lines.

Apoptosis Analysis^[1]

Cell Line:

HL-60, U-937, PC-3, HTB-82, HTB-114, TE-671, HTB-115 and HTB-88 cells
Concentration:

0.5 μM, 5 μM, 20 μM and 50 μM
Incubation Time:

48 hours
Result:

Induced a dose-dependent increase in apoptosis.

In Vivo

Tyrphostin AG 879 (100 mg/kg;subcutaneous injection; administered 10 times in 19 days; for 21 days; athymic, immunodepressed NOD/SCID female mice) treatment induces in vivo a decrease in cancer growth in grafted athymic NOD/SCID mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Athymic, immunodepressed NOD/SCID female mice (20 g) with HTB-114 and HL-60 cells^[1]
Dosage:

100 mg/kg
Administration:

Subcutaneous injection; administered 10 times in 19 days; for 21 days
Result:

Resulted in dramatic reductions in tumor sizes.

Chemical Information

CAS No. 148741-30-4
Appearance Solid
Molecular Weight 316.46
Formula C₁₈H₂₄N₂OS
Color White to yellow
SMILES

S=C(N)/C(C#N)=C/C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1
Synonyms

AG 879
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (3)

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Journal Impact Factor

Nat Commun

Reversal of pre-existing NGFR-driven tumor and immune therapy resistance. [Abstract]

2020 Aug 7;11(1):3946. PMID: 32770055
Pathogens

Cellular Receptor Tyrosine Kinase Signaling Plays Important Roles in SARS-CoV-2 Infection. [Abstract]

2025 Mar 31;14(4):333. PMID: 40333134
Pflugers Arch

Unlocking the potential: unveiling tyrphostins with Michael-reactive cyanoacrylate motif as promising inhibitors of human 5-lipoxygenase. [Abstract]

2024 Dec;476(12):1913-1928. PMID: 39347835

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (158.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.1600 mL

15.7998 mL

31.5996 mL

5 mM

0.6320 mL

3.1600 mL

6.3199 mL

10 mM

0.3160 mL

1.5800 mL

3.1600 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (597 KB)
- English - EN (597 KB)
- Français - FR (597 KB)
- Deutsch - DE (597 KB)
- Norwegian - NO (597 KB)
- Español - ES (597 KB)
- Swedish - SV (597 KB)
- Italian - IT (597 KB)
- Korean - KR (597 KB)
- Portuguese - PT (597 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhou Y, et al. Blockade of EGFR and ErbB2 by the novel dual EGFR and ErbB2 tyrosine kinase inhibitor GW572016 sensitizes human colon carcinoma GEO cells to apoptosis. Cancer Res. 2006 Jan 1;66(1):404-11. [Content Brief]

[2]. Levitzki A, et al. Tyrosine kinase inhibition: an approach to drug development. Science. 1995 Mar 24;267(5205):1782-8. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.1600 mL	15.7998 mL	31.5996 mL	78.9989 mL
	5 mM	0.6320 mL	3.1600 mL	6.3199 mL	15.7998 mL
	10 mM	0.3160 mL	1.5800 mL	3.1600 mL	7.8999 mL
	15 mM	0.2107 mL	1.0533 mL	2.1066 mL	5.2666 mL
	20 mM	0.1580 mL	0.7900 mL	1.5800 mL	3.9499 mL
	25 mM	0.1264 mL	0.6320 mL	1.2640 mL	3.1600 mL
	30 mM	0.1053 mL	0.5267 mL	1.0533 mL	2.6333 mL
	40 mM	0.0790 mL	0.3950 mL	0.7900 mL	1.9750 mL
	50 mM	0.0632 mL	0.3160 mL	0.6320 mL	1.5800 mL
	60 mM	0.0527 mL	0.2633 mL	0.5267 mL	1.3166 mL
	80 mM	0.0395 mL	0.1975 mL	0.3950 mL	0.9875 mL
	100 mM	0.0316 mL	0.1580 mL	0.3160 mL	0.7900 mL

Tyrphostin AG 879

3 Cited Publications

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Tyrphostin AG 879

Bioactive Compound Library Max

Bioactive Compound Library

Apoptosis Compound Library

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Kinase Inhibitor Library

Neuronal Signaling Compound Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

Differentiation Inducing Compound Library

Anti-Hepatitis C Virus Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Obesity Compound Library

Angiogenesis-Related Compound Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Anti-Prostate Cancer Compound Library

Cancer Stem Cells Compound Library

Pain-Related Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Cysteine Targeted Covalent Library

Highly Selective Inhibitors Library

Highly Selective Activators Library

Cytokine Inhibitors Library

Cell Death Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

MCE Bioactive Compound Library

Anti-Brain Cancer Compound Library

Protein Kinase Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Publications Citing Use of MedChemExpress (MCE) Tyrphostin AG 879

All Trk Receptor Isoforms

All EGFR Isoforms

Biological Activity

Chemical Information

Publications (3)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Tyrphostin AG 879 Related Classifications

HY-20878 Related Classifications