1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR
    Trk Receptor

Tyrphostin AG 879 (Synonyms: AG 879)

Cat. No.: HY-20878 Purity: 99.10%
Handling Instructions

TyrphostinAG879 is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation, but not TrKB and TrKC.

For research use only. We do not sell to patients.

Tyrphostin AG 879 Chemical Structure

Tyrphostin AG 879 Chemical Structure

CAS No. : 148741-30-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
5 mg USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
25 mg USD 276 In-stock
Estimated Time of Arrival: December 31
50 mg USD 504 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

TyrphostinAG879 is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation, but not TrKB and TrKC.[1] also a ErbB2 kinase inhibitor, has at least 500-fold higher selectivity to ErbB2 (IC50 = 1 μmol/L) than EGFR (IC50 >500 μmol/L). target: TrKA [1], ErbB2 [2]. IC 50: ErbB2 1 μmol/L [2]. In vitro: TyrphostinAG879 significantly inhibit the A-type potassium currents in the cultured hippocampus neurons.[2] TyrphostinAG879 can reduce gephyrin puncta in GABAergic neurons and PSD-95 puncta in glutamatergic neurons where ErbB4 expression was low. [3] In vivo: Treatment with TyrphostinAG879 in immunodepressed mice graft with leiomyosarcoma or promyelocytic leukemia cells result in dramatic reductions in tumor sizes. [1]

Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (94.80 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1600 mL 15.7998 mL 31.5996 mL
5 mM 0.6320 mL 3.1600 mL 6.3199 mL
10 mM 0.3160 mL 1.5800 mL 3.1600 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

316.46

Formula

C₁₈H₂₄N₂OS

CAS No.

148741-30-4

SMILES

S=C(N)/C(C#N)=C/C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Tyrphostin AG 879
Cat. No.:
HY-20878
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Tyrphostin AG 879

Cat. No.: HY-20878