1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
    Anti-infection
  2. EGFR
    Reverse Transcriptase
  3. AG 555

AG 555 (Synonyms: Tyrphostin AG 555)

Cat. No.: HY-15336 Purity: ≥98.0%
Handling Instructions

AG 555 (Tyrphostin AG 555), a potent antiretroviral drug, is a potent and selective inhibitor of EGFR and blocks Cdk2 activation.

For research use only. We do not sell to patients.

AG 555 Chemical Structure

AG 555 Chemical Structure

CAS No. : 133550-34-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 440 In-stock
Estimated Time of Arrival: December 31
100 mg USD 400 In-stock
Estimated Time of Arrival: December 31
250 mg USD 700 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
1 g   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

AG 555 (Tyrphostin AG 555), a potent antiretroviral drug, is a potent and selective inhibitor of EGFR and blocks Cdk2 activation[1][2].

IC50 & Target[1]

EGFR

 

In Vitro

AG 555 (100 μM) inhibits both the early stages (integration process) and the late stages (viral protein synthesis) in the virus life cycle[1].
Tyrphostins AG555, which blocks Cdk2 activation, induces growth arrest of immortalized cells at G1-S and early S and is very effective in arresting the growth of EGFR overexpressor cells[2].
Tyrphostin AG 555 can selectively suppress BPV-1 transcription through MAP kinase pathway activation and binding of phosphorylated Jun/ATF-2 at a novel intragenic regulatory sequence[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: NIH/3T3 uninfected cells and NIH/3T3-Mo-MuLV chronically infected cells.
Concentration: 100 μM.
Incubation Time: 1 hour.
Result: Inhibited Mo-MuLV proviral DNA integration.
Molecular Weight

322.36

Formula

C₁₉H₁₈N₂O₃

CAS No.

133550-34-2

SMILES

O=C(NCCCC1=CC=CC=C1)/C(C#N)=C/C2=CC=C(O)C(O)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (310.21 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1021 mL 15.5106 mL 31.0212 mL
5 mM 0.6204 mL 3.1021 mL 6.2042 mL
10 mM 0.3102 mL 1.5511 mL 3.1021 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.76 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.76 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

AG 555Tyrphostin AG 555AG555AG-555Tyrphostin AG555Tyrphostin AG-555EGFRReverse TranscriptaseEpidermal growth factor receptorErbB-1HER1antiretroviralBPVBovinePapillomavirusInhibitorinhibitorinhibit

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AG 555
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