1. Protein Tyrosine Kinase/RTK
    JAK/STAT Signaling
  2. EGFR
  3. Tyrphostin AG30

Tyrphostin AG30 (Synonyms: AG30)

Cat. No.: HY-118532 Purity: 98.60%
Handling Instructions

Tyrphostin AG30 (AG30) is a potent and selective EGFR tyrosine kinase inhibitor. Tyrphostin AG30 (AG30) selectively inhibits self renewal induction by c-ErbB, and is able to inhibit activation of STAT5 by c-ErbB in primary erythroblasts.

For research use only. We do not sell to patients.

Tyrphostin AG30 Chemical Structure

Tyrphostin AG30 Chemical Structure

CAS No. : 122520-79-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 56 In-stock
Estimated Time of Arrival: December 31
2 mg USD 50 In-stock
Estimated Time of Arrival: December 31
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
25 mg USD 220 In-stock
Estimated Time of Arrival: December 31
50 mg USD 390 In-stock
Estimated Time of Arrival: December 31
100 mg USD 650 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Tyrphostin AG30 (AG30) is a potent and selective EGFR tyrosine kinase inhibitor. Tyrphostin AG30 (AG30) selectively inhibits self renewal induction by c-ErbB, and is able to inhibit activation of STAT5 by c-ErbB in primary erythroblasts[1][2].

Molecular Weight

205.17

Formula

C₁₀H₇NO₄

CAS No.

122520-79-0

SMILES

O=C(/C(C#N)=C/C1=CC=C(C(O)=C1)O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (609.25 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8740 mL 24.3700 mL 48.7401 mL
5 mM 0.9748 mL 4.8740 mL 9.7480 mL
10 mM 0.4874 mL 2.4370 mL 4.8740 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (10.14 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (10.14 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Tyrphostin AG30AG30Tyrphostin AG 30Tyrphostin AG-30AG 30AG-30EGFREpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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Product name:
Tyrphostin AG30
Cat. No.:
HY-118532
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