CRISPR/Cas9

By Targets:	CRISPR/Cas9 (13) Adrenergic Receptor (1) Antibiotic (1) Apoptosis (3) Autophagy (2) Bacterial (1) Bcr-Abl (1) DNA/RNA Synthesis (2) Epigenetic Reader Domain (1) Estrogen Receptor/ERR (1) HIV (3) HSV (1) Isotope-Labeled Compounds (2) Liposome (5) Microtubule/Tubulin (1) Mitophagy (1) RAD51 (1)
By Research Areas:	Cancer (12) Endocrinology (1) Infection (5)
Click Chemistry:	Azide (2)

Targets Recommended: CRISPR/Cas9

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136251

BRD0539	CRISPR/Cas9	Infection
BRD0539 is a cell-permeable and non-toxic inhibitor of *CRISPR-Cas9. BRD0539 inhibits Streptococcus pyogenes* Cas9 (SpCas9) (apparent IC₅₀=22 μM) in an in vitro DNA cleavage assay .

HY-148049

TT3

Liposome Others

TT3 is an ionizable lipid-like materials for mRNA and CRISPR/Cas9 delivery .
HY-19793

RS-1

1 Publications Verification

RAD51 CRISPR/Cas9 Cancer

RS-1 is a RAD51 activator, and also increases CRISPR/Cas9-mediated knock-in efficiencies.
HY-156448

80-O14B

Liposome Cancer

80-O14B is an cationic lipid-like compound for CRISPR/Cas9 delivery .
HY-145692

Cas9-IN-3

CRISPR/Cas9 Others

Cas9-IN-3 is a potent Cas9 inhibitor (IC₅₀=28 μM). CRISPR/Cas systems have revolutionized gene editing in various species .

TT3	Liposome	Others
TT3 is an ionizable lipid-like materials for mRNA and CRISPR/Cas9 delivery .

RS-1 1 Publications Verification	RAD51 CRISPR/Cas9	Cancer
RS-1 is a RAD51 activator, and also increases *CRISPR/Cas9*-mediated knock-in efficiencies.

80-O14B	Liposome	Cancer
80-O14B is an cationic lipid-like compound for CRISPR/Cas9 delivery .

Cas9-IN-3	CRISPR/Cas9	Others
Cas9-IN-3 is a potent *Cas9* inhibitor (IC₅₀=28 μM). CRISPR/Cas systems have revolutionized gene editing in various species .

HY-136572

CEM114	Epigenetic Reader Domain CRISPR/Cas9	Cancer
CEM114 is an effective chemical epigenetic modifier (CEM) that recruits endogenous chromatin machinery through CRISPR-Cas9 systems .

HY-107845

SCR7 pyrazine 5+ Cited Publications	CRISPR/Cas9 DNA/RNA Synthesis Apoptosis	Cancer
SCR7 pyrazine is a DNA ligase IV inhibitor that blocks nonhomologous end-joining (NHEJ) in a ligase IV-dependent manner. SCR7 pyrazine is also a *CRISPR/Cas9* enhancer which increases the efficiency of Cas9-mediated homology-directed repair (HDR). SCR7 pyrazine induces cell apoptosis and has anticancer activity .

HY-17413

Zidovudine 5 Publications Verification Azidothymidine; AZT; ZDV	HIV CRISPR/Cas9	Infection Cancer
Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency.

HY-12742

SCR7	DNA/RNA Synthesis CRISPR/Cas9 Apoptosis	Cancer
SCR7 is an unstable form that can be autocyclized into a stable form SCR7 pyrazine. SCR7 pyrazine is a DNA ligase IV inhibitor that blocks nonhomologous end-joining (NHEJ) in a ligase IV-dependent manner. SCR7 pyrazine is also a *CRISPR/Cas9* enhancer which increases the efficiency of Cas9-mediated homology-directed repair (HDR). SCR7 pyrazine induces cell apoptosis and has anticancer activity .

HY-W590683

9A1P9	Liposome CRISPR/Cas9	Others
9A1P9 is a multi-tail ionizable cationic phospholipid. 9A1P9 induces membrane destabilization. 9A1P9 can be used for *CRISPR-Cas9* gene editing in mice .

HY-13520

Nocodazole 50+ Cited Publications Oncodazole; R17934	Microtubule/Tubulin Bcr-Abl CRISPR/Cas9 Autophagy Apoptosis	Cancer
Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of microtubule. Nocodazole binds to β-tubulin and disrupts microtubule assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl, and activates *CRISPR/Cas9*.

HY-19334

L755507 1 Publications Verification	Adrenergic Receptor CRISPR/Cas9	Endocrinology Cancer
L755507 is a potent, selective agonist of β₃-AR with an IC₅₀ of 35 nM. L755507 enhances the homology-directed repair (HDR)-mediated genome editing in CRISPR/Cas9 nickase system .

HY-16950

4-Hydroxytamoxifen 15+ Cited Publications (Z)-4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen; (Z)-Afimoxifene	Estrogen Receptor/ERR	Cancer
4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) is an orally active, selective estrogen receptor modulator (SERM). 4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) induces CRISPR/Cas9 systems based on ER mediated nucleus translocation .

HY-16592

Brefeldin A Maximum Cited Publications 62 Publications Verification BFA; Cyanein; Decumbin	Autophagy CRISPR/Cas9 Mitophagy HSV Antibiotic Bacterial	Infection Cancer
Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus . Brefeldin A is also an autophagy and mitophagy inhibitor . Brefeldin A is a *CRISPR/Cas9* activator . Brefeldin A inhibits HSV-1 and has anti-cancer activity .

HY-145798

N1,N3,N5-Tris(4-dodecylhexadecyl)benzene-1,3,5-tricarboxamide	Liposome	Others
N1,N3,N5-Tris(4-dodecylhexadecyl)benzene-1,3,5-tricarboxamide is an analogue of TT3 (HY-148049). TT3 is an ionizable lipid-like materials for mRNA and CRISPR/Cas9 delivery .

HY-157252

CL4F8-6	Liposome	Cancer
CL4F8-6 is an ionizable cationic lipid with a pK_a of 6.14. CL4F8-6 can be used in lipid nanoparticles (LNPs)-based mRNA therapeutics. CL4F8-6 LNPs carrying Cas9 mRNA and sgRNA could induce CRISPR-mediated gene knockdown in mice .

HY-17413S

Zidovudine-d3 Azidothymidine-d₃; AZT-d₃; ZDV-d₃	Isotope-Labeled Compounds HIV CRISPR/Cas9	Infection
Zidovudine-d₃ is the deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Zidovudine-d3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-17413S1

Zidovudine-13C,d3 Azidothymidine-¹³C,d₃; AZT-¹³C,d₃; ZDV-¹³C,d₃	Isotope-Labeled Compounds HIV CRISPR/Cas9	Infection
Zidovudine- ¹³C,d₃ is the ¹³C- and deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Zidovudine-13C,d3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Cat. No.	Product Name	Type

HY-148049

TT3

Drug Delivery

TT3 is an ionizable lipid-like materials for mRNA and CRISPR/Cas9 delivery .
HY-156448

80-O14B

Drug Delivery

80-O14B is an cationic lipid-like compound for CRISPR/Cas9 delivery .

TT3	Drug Delivery
TT3 is an ionizable lipid-like materials for mRNA and CRISPR/Cas9 delivery .

80-O14B	Drug Delivery
80-O14B is an cationic lipid-like compound for CRISPR/Cas9 delivery .

HY-145798

N1,N3,N5-Tris(4-dodecylhexadecyl)benzene-1,3,5-tricarboxamide	Drug Delivery
N1,N3,N5-Tris(4-dodecylhexadecyl)benzene-1,3,5-tricarboxamide is an analogue of TT3 (HY-148049). TT3 is an ionizable lipid-like materials for mRNA and CRISPR/Cas9 delivery .

HY-157252

CL4F8-6	Drug Delivery
CL4F8-6 is an ionizable cationic lipid with a pK_a of 6.14. CL4F8-6 can be used in lipid nanoparticles (LNPs)-based mRNA therapeutics. CL4F8-6 LNPs carrying Cas9 mRNA and sgRNA could induce CRISPR-mediated gene knockdown in mice .

Cat. No.	Product Name	Target	Research Area

HY-P10068

LAH5	Peptides	Others
LAH5 is an amphipathic cell-penetrating peptide. LAH5 effectively delivers *CRISPR-Cas9* components into the nuclei of target cells by forming nanocomplexes with both RNP and RNP/HDR cargo .

HY-P10068A

LAH5 TFA	Peptides	Others
LAH5 TFA is an amphipathic cell-penetrating peptide. LAH5 THA effectively delivers *CRISPR-Cas9* components into the nuclei of target cells by forming nanocomplexes with both RNP and RNP/HDR cargo .

HY-P5307A

Peptide A5K acetate INF7-A5K-TAT acetate	Peptides	Cancer
Peptide A5K (INF7-A5K-TAT acetate) acetate is a INF7-TAT derivative and is used for CRISPR RNP delivery into T cells. Peptide A5K acetate effectively promotes the delivery of Cas9 RNP to natural killer (NK) cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-16592

Brefeldin A 60+ Cited Publications BFA; Cyanein; Decumbin	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antiviral Disease Research Anticancer Disease Research Fields	Autophagy CRISPR/Cas9 Mitophagy HSV Antibiotic Bacterial
Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus . Brefeldin A is also an autophagy and mitophagy inhibitor . Brefeldin A is a *CRISPR/Cas9* activator . Brefeldin A inhibits HSV-1 and has anti-cancer activity .

Tag:	His (3) Tag Free (1)
Source:	Sf9 insect cells (1) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P77727

	CRISPR-Cas9 Protein, S. pyogenes (His) CRISPR-associated endonuclease Cas9/Csn1; Cas9; SpCas9; SpyCas9	Others	E. coli
	The CRISPR-Cas9 protein is part of an immune system that defends against genetic elements. It processes RNA and aids in cleaving DNA targets. Protein and guide RNAs are necessary for its function. The protein recognizes specific sequences to distinguish self from nonself and provides immunity against matching genetic elements. CRISPR-Cas9 Protein, S. pyogenes (His) is the recombinant CRISPR-Cas9 protein, expressed by E. coli , with His tagged. The total length of CRISPR-Cas9 Protein, S. pyogenes (His) is 1367 a.a., with molecular weight of ~163 kDa.

HY-P701235

	CRISPR-Cas9 Protein, S. pyogenes (NLS) CRISPR-associated endonuclease Cas9/Csn1; Cas9; SpCas9; SpyCas9	Others	E. coli
	The CRISPR-Cas9 protein is part of an immune system that defends against genetic elements. It processes RNA and aids in cleaving DNA targets. Protein and guide RNAs are necessary for its function. The protein recognizes specific sequences to distinguish self from nonself and provides immunity against matching genetic elements. CRISPR-Cas9 Protein, S. pyogenes (NLS) is the recombinant CRISPR-Cas9 protein, expressed by E. coli , with tag free. The total length of CRISPR-Cas9 Protein, S. pyogenes (NLS) is 1368 a.a., with molecular weight of ~160 kDa.

HY-P75328

	CRISPR-Cas9 Protein, Streptococcus pyogenes M1 (sf9, His) Cas9; CRISPR; CRISPR-associated endonuclease Cas9/Csn1; SpyCas9	Others	Sf9 insect cells
	The CRISPR-Cas9 protein is part of an immune system that defends against genetic elements. It processes RNA and aids in cleaving DNA targets. Protein and guide RNAs are necessary for its function. The protein recognizes specific sequences to distinguish self from nonself and provides immunity against matching genetic elements. CRISPR-Cas9 Protein, Streptococcus pyogenes M1 (sf9, His) is the recombinant CRISPR-Cas9 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of CRISPR-Cas9 Protein, Streptococcus pyogenes M1 (sf9, His) is 1368 a.a., with molecular weight of ~163 kDa.

HY-P77728

	*GMP-CRISPR-Cas9* Protein, S. pyogenes (His)** CRISPR-associated endonuclease Cas9/Csn1; Cas9; SpCas9; SpyCas9	Others	E. coli
	The CRISPR-Cas9 protein is part of an immune system that defends against genetic elements. It processes RNA and aids in cleaving DNA targets. Protein and guide RNAs are necessary for its function. The protein recognizes specific sequences to distinguish self from nonself and provides immunity against matching genetic elements. GMP-CRISPR-Cas9 Protein, S. pyogenes (His) is the recombinant GMP-CRISPR-Cas9 protein, expressed by E. coli , with His labeled tag. The total length of GMP-CRISPR-Cas9 Protein, S. pyogenes (His) is 1367 a.a., with molecular weight of ~163 kDa.


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Cat. No.	Product Name	Chemical Structure

HY-17413S

Zidovudine-d3
Zidovudine-d₃ is the deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Zidovudine-d3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Zidovudine-d3

Zidovudine-d₃ is the deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Zidovudine-d3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-17413S1

Zidovudine-13C,d3
Zidovudine- ¹³C,d₃ is the ¹³C- and deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Zidovudine-13C,d3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Zidovudine-13C,d3

Zidovudine- ¹³C,d₃ is the ¹³C- and deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Zidovudine-13C,d3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Cat. No.	Product Name	Application	Reactivity

HY-P81938

CRISPR Cas9 SA Antibody (YA1683)

Cas9; CRISPR-associated endonuclease Cas9/Csn1; CRISPR-Cas9/Csn1; csn1; SpyCas9
WB, IHC-P, ICC/IF, IP, FC Staphylococcus aureus

Cat. No.	Product Name		Classification

HY-17413S

Zidovudine-d3 Azidothymidine-d₃; AZT-d₃; ZDV-d₃		Azide
Zidovudine-d₃ is the deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Zidovudine-d3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-17413S1

Zidovudine-13C,d3 Azidothymidine-¹³C,d₃; AZT-¹³C,d₃; ZDV-¹³C,d₃		Azide
Zidovudine- ¹³C,d₃ is the ¹³C- and deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Zidovudine-13C,d3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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Isotope-Labeled Compounds

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CRISPR/Cas9

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Peptides

NaturalProducts

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Isotope-Labeled Compounds

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