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Results for "

Caspase-2 Inhibitor

" in MedChemExpress (MCE) Product Catalog:

16

Inhibitors & Agonists

7

Peptides

2

Oligonucleotides

Targets Recommended:
Cat. No. 상품명 Target 연구분야 Chemical Structure
  • HY-164388
    Z-VAD
    15+ Cited Publications

    		 Caspase Apoptosis Autophagy Necroptosis Cardiovascular Disease Cancer
    Z-VAD is an irreversible, broad-spectrum pan-caspase inhibitor that can inhibit a variety of caspases including caspase-3, -6, -7, -8, -9, etc. (with a weaker inhibitory effect on caspase-2). Z-VAD can block apoptosis signaling pathways, induce autophagy and necrosis in tumor cells, and has anti-angiogenic activity. Z-VAD can enhance the sensitivity of breast cancer and lung cancer cells to radiotherapy in vitro and in vivo, and prolong the growth delay of tumor xenograft models. Z-VAD is well tolerated and is mainly used in research related to cancer radiosensitization and cell death pathway regulation .
    Z-VAD
  • HY-120838
    Heptelidic acid
    1 Publications Verification

    Koningic acid

    		 Caspase Infection Cancer
    Heptelidic acid (Koningic acid) is a sesquiterpene antibiotic . Heptelidic acid inhibits Etoposide-induced apoptosis via downregulation of caspases . Koningic acid (KA) is a specific GAPDH inhibitor with an IC50of 90 μM .
    Heptelidic acid
  • HY-P0109A
    Z-FA-FMK
    5+ Cited Publications

    (1S)-Z-FA-FMK

    		 SARS-CoV Cathepsin Apoptosis Caspase Infection Cancer
    Z-FA-FMK ((1S)-Z-FA-FMK) is a potent Cathepsin B and L inhibitor. Z-FA-FMK blocks the induction of DEVDase activity, DNA fragmentation, and externalization of phosphatidylserine by selective synthetic retinoid-related molecules (RRMs). Z-FA-FMK inhibits apoptosis. Z-FA-FMK inhibits caspase activity and selectively inhibits recombinant effector caspases 2, -3, -6, and -7. Z-FA-FMK is a viral inhibitor. Z-FA-FMK inhibits reovirus replication in a susceptible host .
    Z-FA-FMK
  • HY-P1008
    Z-VDVAD-FMK
    5 Publications Verification

    Z-VD(OMe)VAD(OMe)-FMK

    		 Caspase Cancer
    Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis .
    Z-VDVAD-FMK
  • HY-120314
    GEA 3162

    		Apoptosis Caspase Endogenous Metabolite Inflammation/Immunology
    GEA 3162 is an orally active compound that acts as a NO/ONOO⁻ donor. GEA 3162 significantly inhibits the activation of human polymorphonuclear leukocytes (PMNs) through the cGMP pathway, inhibits the release of inflammatory mediators, and exerts anti-inflammatory and protective effects. GEA 3162 induces apoptosis of neutrophils and bone marrow cells by activating caspase-2/3/8/9 through the ONOO⁻ pathway. GEA 3162 has a bidirectional effect in the rat gastric ulcer model: at low doses, it significantly reduces gastric mucosal damage, while at high doses, it aggravates the ulcer area. GEA 3162 can be used for research on inflammatory conditions such as gastric ulcers .
    GEA 3162
  • HY-158820
    Cosdosiran
    1 Publications Verification

    QPI-1007

    		 Small Interfering RNA (siRNA) Caspase Cardiovascular Disease
    Cosdosiran is a chemically modified siRNA designed to temporarily inhibit expression of the caspase 2 protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.
    Cosdosiran
  • HY-P1008A
    Z-VDVA-(DL-Asp)-FMK

    Z-VD(OMe)VAD(OMe)-(DL-Asp)-FMK

    		 Caspase Cancer
    Z-VDVA-(DL-Asp)-FMK is a Z-VDVAD-FMK derivative. Z-VDVAD-FMK (HY-P1008) is a special inhibitor of caspase-2 .
    Z-VDVA-(DL-Asp)-FMK
  • HY-P10147
    Ac-LDESD-AMC

    		Caspase Cancer
    Ac-LDESD-AMC is a caspase-2 inhibitor. Ac-LDESD-AMC has a peptide sequence of Leu-Asp-Glu-Ser-Asp .
    Ac-LDESD-AMC
  • HY-123185
    (Rac)-Z-FA-FMK

    		Cathepsin Caspase SARS-CoV Interleukin Related NF-κB Infection
    (Rac)-Z-FA-FMK is the racemate of Z-FA-FMK. (Rac)-Z-FA-FMK is an inhibitor of cathepsin B with a Ki of 1.5 μM. (Rac)-Z-FA-FMK inhibits caspase-2, -3, -6, -7, and -9 with IC50s of 6.147, 15.41, 32.45, 9.077, and 110.7 μM. (Rac)-Z-FA-FMK inhibits the main protease of SARS-CoV-2 replication with an IC50 of 11.39 μM. (Rac)-Z-FA-FMK inhibits the increased IL-1β level induced by LPS and NF-κB transactivation in macrophages .
    (Rac)-Z-FA-FMK
  • HY-120923
    GUT-70

    		HSP NF-κB HIV Apoptosis Caspase Infection Cancer
    GUT-70, a tricyclic coumarin, is a Hsp90 inhibitor. GUT-70 activates the caspase 2, 3, 8 and 9, and induces the apoptosis in leukemic cells. GUT-70 inhibits HIV-1 replication in chronically infected cells via suppression of the NF-κB pathway. GUT-70 can be used for the study of leukemic, mantle cell lymphoma (MCL) and HIV-1 infection .
    GUT-70
  • HY-P2012
    TRP-601

    		Caspase Bcl-2 Family Others
    TRP-601 is a caspase inhibitor. TRP-601 reversed the increased expression of active caspase-2, the activation of endogenous apoptotic pathway and the up-regulation of key protein triggered by hyperoxia .
    TRP-601
  • HY-P0109
    (S,S)-Z-FA-FMK

    		Cathepsin Others
    (S,S)-Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor. (S,S)-Z-FA-FMK blocks LPS-induced production of IL-1α and IL-1β. (S,S)-Z-FA-FMK can be used as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position .
    (S,S)-Z-FA-FMK
  • HY-134567
    Ac-VDVAD-CHO

    		Caspase Others
    Ac-VDVAD-CHO is a caspase-2/3 inhibitor (IC50: 46 and 15 nM) .
    Ac-VDVAD-CHO
  • HY-134567A
    Ac-VDVAD-CHO TFA

    		Caspase Others
    Ac-VDVAD-CHO (TFA) is a caspase-2/3 inhibitor (IC50: 46 and 15 nM) .
    Ac-VDVAD-CHO TFA
  • HY-158820A
    Cosdosiran sodium
    1 Publications Verification

    QPI-1007 sodium

    		 Small Interfering RNA (siRNA) Caspase Cardiovascular Disease
    Cosdosiran sodium is a chemically modified siRNA designed to temporarily inhibit expression of the caspase 2 protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.
    Cosdosiran sodium
  • HY-120314A
    GEA 3162 hydrochloride

    		Apoptosis Caspase Endogenous Metabolite Inflammation/Immunology
    GEA 3162 hydrochloride is an orally active compound that acts as a NO/ONOO⁻ donor. GEA 3162 hydrochloride significantly inhibits the activation of human polymorphonuclear leukocytes (PMNs) through the cGMP pathway, inhibits the release of inflammatory mediators, and exerts anti-inflammatory and protective effects. GEA 3162 hydrochloride induces apoptosis of neutrophils and bone marrow cells by activating caspase-2/3/8/9 through the ONOO⁻ pathway. GEA 3162 hydrochloride has a bidirectional effect in the rat gastric ulcer model: at low doses, it significantly reduces gastric mucosal damage, while at high doses, it aggravates the ulcer area. GEA 3162 hydrochloride can be used for research on inflammatory conditions such as gastric ulcers .
    GEA 3162 hydrochloride

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