2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease NF-κB Anti-infection Apoptosis
  3. HSP NF-κB HIV Apoptosis Caspase
  4. GUT-70

GUT-70, a tricyclic coumarin, is a Hsp90 inhibitor. GUT-70 activates the caspase 2, 3, 8 and 9, and induces the apoptosis in leukemic cells. GUT-70 inhibits HIV-1 replication in chronically infected cells via suppression of the NF-κB pathway. GUT-70 can be used for the study of leukemic, mantle cell lymphoma (MCL) and HIV-1 infection.

For research use only. We do not sell to patients.

GUT-70

GUT-70 Chemical Structure

CAS No. : 161633-75-6

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GUT-70 Related Antibodies

Top Publications Citing Use of Products

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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HIV HIV-1 HIV-2

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

GUT-70, a tricyclic coumarin, is a Hsp90 inhibitor. GUT-70 activates the caspase 2, 3, 8 and 9, and induces the apoptosis in leukemic cells. GUT-70 inhibits HIV-1 replication in chronically infected cells via suppression of the NF-κB pathway. GUT-70 can be used for the study of leukemic, mantle cell lymphoma (MCL) and HIV-1 infection[1][2][3].

IC50 & Target[1].[2][3]

HSP90

 

HIV-1

 

NF-κB

 

Caspase-2

 

Caspase 3

 

Caspase-8

 

Caspase-9

 

Cellular Effect
Cell Line Type Value Description References
MOLT-4 EC50
3.41 μM
Compound: GUT-70
Antiviral activity against X4 tropic Human immunodeficiency virus 1 NL4-3 infected human Molt4 cells assessed as intracellular p24 expression after 4 to 7 days by flow cytometry
Antiviral activity against X4 tropic Human immunodeficiency virus 1 NL4-3 infected human Molt4 cells assessed as intracellular p24 expression after 4 to 7 days by flow cytometry
[PMID: 23290051]
MOLT-4 IC50
> 10 μM
Compound: GUT-70
Cytotoxicity against Homo sapiens (human) MOLT4 cells by MTT assay
Cytotoxicity against Homo sapiens (human) MOLT4 cells by MTT assay
[PMID: 23290051]
Raji IC50
268 molar ratio
Compound: 7
Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as early antigen activation after 48 hrs relative to control
Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as early antigen activation after 48 hrs relative to control
[PMID: 12662094]
TZM IC50
> 10 μM
Compound: GUT-70
Cytotoxicity against Homo sapiens (human) TZM-bl cells by MTT assay
Cytotoxicity against Homo sapiens (human) TZM-bl cells by MTT assay
[PMID: 23290051]
U1 EC50
3.48 μM
Compound: GUT-70
Antiviral activity against Human immunodeficiency virus 1 infected U1 cells assessed as intracellular p24 expression after 24 hr by flow cytometry in presence of PMA
Antiviral activity against Human immunodeficiency virus 1 infected U1 cells assessed as intracellular p24 expression after 24 hr by flow cytometry in presence of PMA
[PMID: 23290051]
U1 EC50
4.32 μM
Compound: GUT-70
Antiviral activity against Human immunodeficiency virus 1 infected U1 cells assessed as intracellular p24 expression after 24 hr by flow cytometry in presence of TNF-alpha
Antiviral activity against Human immunodeficiency virus 1 infected U1 cells assessed as intracellular p24 expression after 24 hr by flow cytometry in presence of TNF-alpha
[PMID: 23290051]
U1 IC50
8.44 μM
Compound: GUT-70
Cytotoxicity against Homo sapiens (human) U1 cells by MTT assay in presence of PMA
Cytotoxicity against Homo sapiens (human) U1 cells by MTT assay in presence of PMA
[PMID: 23290051]
U1 IC50
8.44 μM
Compound: GUT-70
Cytotoxicity against Homo sapiens (human) U1 cells by MTT assay in presence of TNF-alpha
Cytotoxicity against Homo sapiens (human) U1 cells by MTT assay in presence of TNF-alpha
[PMID: 23290051]
Molecular Weight

382.45

Formula

C23H26O5
CAS No.
SMILES

O=C1C=C(CCC)C2=C3C(C=CC(C)(C)O3)=C(OC)C(C(/C(C)=C/C)=O)=C2O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GUT-70 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GUT-70161633-75-6GUT70GUT 70HSPNF-κBHIVApoptosisCaspaseHeat shock proteinsNuclear factor-κBNuclear factor-kappaBHuman immunodeficiency virusHsp90 inhibitortricyclic coumarincaspase 2caspase 3caspase 8caspase 9apoptosisNF-κB pathwayHIV-1 replicationleukemicmantle cell lymphomaInhibitorinhibitorinhibit

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