161633-75-6
Chemical Structure
GUT-70
- CAS No.: 161633-75-6
- Formula:C23H26O5
- Molecular Weight:382.45
IUPAC Name: (E)-5-methoxy-2,2-dimethyl-6-(2-methylbut-2-enoyl)-10-propyl-2H,8H-pyrano[2,3-f]chromen-8-one
InChIKey: RMUWCAYGHBNRQJ-MDWZMJQESA-N
SMILES: O=C1C=C(CCC)C2=C3C(C=CC(C)(C)O3)=C(OC)C(C(/C(C)=C/C)=O)=C2O1
Biological Activity: GUT-70, a tricyclic coumarin, is a Hsp90 inhibitor. GUT-70 activates the caspase 2, 3, 8 and 9, and induces the apoptosis in leukemic cells. GUT-70 inhibits HIV-1 replication in chronically infected cells via suppression of the NF-κB pathway. GUT-70 can be used for the study of leukemic, mantle cell lymphoma (MCL) and HIV-1 infection[1][2][3].
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GUT-70 | GUT-70, a tricyclic coumarin, is a Hsp90 inhibitor. GUT-70 activates the caspase 2, 3, 8 and 9, and induces the apoptosis in leukemic cells. GUT-70 inhibits HIV-1 replication in chronically infected cells via suppression of the NF-κB pathway. GUT-70 can be used for the study of leukemic, mantle cell lymphoma (MCL) and HIV-1 infection. | |||||||||||||||||||||
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References
- [1]. Kimura S, et al. Inhibition of leukemic cell growth by a novel anti-cancer drug (GUT-70) from calophyllum brasiliense that acts by induction of apoptosis. Int J Cancer. 2005 Jan 1;113(1):158-65. [Content Brief]
- [2]. Jin L, et al. Antiproliferative and proapoptotic activity of GUT-70 mediated through potent inhibition of Hsp90 in mantle cell lymphoma. Br J Cancer. 2011 Jan 4;104(1):91-100. [Content Brief]
- [3]. Matsuda K, et al. Inhibition of HIV-1 entry by the tricyclic coumarin GUT-70 through the modification of membrane fluidity. Biochem Biophys Res Commun. 2015 Feb 13;457(3):288-94. [Content Brief]
