Inhibition of HIV-1 replication by a tricyclic coumarin GUT-70 in acutely and chronically infected cells

  • Bioorg Med Chem Lett. 2013 Feb 1;23(3):606-9. doi: 10.1016/j.bmcl.2012.12.034.
Eriko Kudo  1 ,  Manabu Taura ,  Kouki Matsuda ,  Masako Shimamoto ,  Ryusho Kariya ,  Hiroki Goto ,  Shinichiro Hattori ,  Shinya Kimura ,  Seiji Okada
Affiliations
  • 1. Division of Hematopoiesis, Center for AIDS Research, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan.
PMID: 23290051 DOI: 10.1016/j.bmcl.2012.12.034
Abstract

The anti-HIV-1 activity of GUT-70, a natural product derived from the stem bark of Chlophyllum brasiliense, was evaluated. GUT-70 inhibited HIV-1 replication in both acutely and chronically infected cells through suppression of NF-κB. Our results strengthen the idea that NF-κB pathway is one of the potential targets to control HIV-1 replication and that GUT-70 could serve as a lead compound to develop novel therapeutic agents against HIV-1 Infection.