(S,S)-Z-FA-FMK
Based on 1 publication(s) in Google Scholar
(S,S)-Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor. (S,S)-Z-FA-FMK blocks LPS-induced production of IL-1α and IL-1β. (S,S)-Z-FA-FMK can be used as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position.
For research use only. We do not sell to patients.
- CAS No.: 105637-38-5
- Formula: C21H23FN2O4
- Molecular Weight:386.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) (S,S)-Z-FA-FMK
MoreAll Cathepsin Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
>100 μM
Compound: 1; Z-FA-FMK
|
Inhibition of recombinant human cathepsin D (400 residues) expressed in CHO cells using 5-FAM/QXL 520 FRET peptide as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate reader analysis
Inhibition of recombinant human cathepsin D (400 residues) expressed in CHO cells using 5-FAM/QXL 520 FRET peptide as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate reader analysis
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[PMID: 27563406] |
| CHO | IC50 |
0.3 μM
Compound: 1; Z-FA-FMK
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Inhibition of recombinant human cathepsin B (332 residues) expressed in CHO cells using Z-FR-AMC as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate reader analysis
Inhibition of recombinant human cathepsin B (332 residues) expressed in CHO cells using Z-FR-AMC as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate reader analysis
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[PMID: 27563406] |
| HEK-293T | CC50 |
>100 μM
Compound: 1; Z-FA-FMK
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Cytotoxicity against HEK293T cells after 24 hrs
Cytotoxicity against HEK293T cells after 24 hrs
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[PMID: 27563406] |
Chemical Information
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CAS No. 105637-38-5
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Molecular Weight 386.42
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Formula C21H23FN2O4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Purity & Documentation
References
[1]. Koike S, et al. Advanced Glycation End-Products Induce Apoptosis of Vascular Smooth Muscle Cells: A Mechanism for Vascular Calcification. Int J Mol Sci. 2016;17(9):1567. Published 2016 Sep 16. [Content Brief]
[2]. Harrison JS, et al. The role of VDR and BIM in potentiation of cytarabine-induced cell death in human AML blasts. Oncotarget. 2016;7(24):36447-36460. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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