1. Anti-infection
  2. SARS-CoV
  3. Z-FA-FMK

Z-FA-FMK (Synonyms: (1S)-Z-FA-FMK)

Cat. No.: HY-P0109A Purity: >98.0%
Handling Instructions

Z-FA-FMK ((1S)-Z-FA-FMK; Compound 6) is a broad-spectrum halomethyl ketone inhibitor sgainst Coronavirus (SARS-CoV) main protease 3CL with a Ki of 25.7 μM.

For research use only. We do not sell to patients.

Z-FA-FMK Chemical Structure

Z-FA-FMK Chemical Structure

CAS No. : 197855-65-5

Size Price Stock Quantity
1 mg USD 70 In-stock
Estimated Time of Arrival: December 31
5 mg USD 240 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Z-FA-FMK ((1S)-Z-FA-FMK; Compound 6) is a broad-spectrum halomethyl ketone inhibitor sgainst Coronavirus (SARS-CoV) main protease 3CL with a Ki of 25.7 μM[1].

IC50 & Target

Ki: 25.7 μM (SARS Protease 3CLpro)[1]

Molecular Weight

386.42

Formula

C₂₁H₂₃FN₂O₄

CAS No.

197855-65-5

SMILES

O=C(OCC1=CC=CC=C1)N[[email protected]@H](CC2=CC=CC=C2)C(NC(C)C(CF)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
-20°C 1 year
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (646.96 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5879 mL 12.9393 mL 25.8786 mL
5 mM 0.5176 mL 2.5879 mL 5.1757 mL
10 mM 0.2588 mL 1.2939 mL 2.5879 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.38 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.38 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.38 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Z-FA-FMK(1S)-Z-FA-FMKSARS-CoVSARS coronavirusCoronavirusprotease3CLInhibitorinhibitorinhibit

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Z-FA-FMK
Cat. No.:
HY-P0109A
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