CuS

By Targets:	Apoptosis (5) Autophagy (2) Bacterial (2) Endonuclease (1) ERK (1) Fc Receptor (FcR) (1) Fluorescent Dye (2) Fungal (3) Isotope-Labeled Compounds (1) NF-κB (3) Reference Standards (1) Transmembrane Glycoprotein (1) Virus Protease (2)
By Research Areas:	Cancer (9) Cardiovascular Disease (1) Infection (4) Inflammation/Immunology (3) Neurological Disease (1)
Oligonucleotides:	Antisense Oligonucleotides (5)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99014

Cusatuzumab 1 Publications Verification ARGX-110	Fc Receptor (FcR) NF-κB	Inflammation/Immunology Cancer
Cusatuzumab (ARGX-110) is a selective competitive blocker targeting CD70 (with an equilibrium dissociation constant of 17 pM for binding to human CD70). Cusatuzumab also possesses enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) activity. It is a humanized IgG1 monoclonal antibody, artificially synthesized through humanization and genetic engineering modifications (CH2 region mutation to enhance effector function). Cusatuzumab has a dual mechanism of action: firstly, it competitively blocks the interaction between CD70 and CD27, inhibiting the CD27-NF-κB signaling pathway, reducing regulatory T cell (Treg) activation and tumor cell proliferation; secondly, by enhancing binding to FcγRIIIa, it mediates ADCC and antibody-dependent cellular phagocytosis (ADCP), directly lysing CD70-positive tumor cells. Cusatuzumab can efficiently eliminate leukemia stem cells (LSCs), induce tumor cell differentiation and apoptosis, restore immune surveillance, and target CD70-positive tumors. Cusatuzumab is used in the study of acute myeloid leukemia (AML) .

HY-N0017

Bergenin 5+ Cited Publications CuScutin	NF-κB Autophagy Apoptosis Bacterial Fungal Virus Protease	Infection Inflammation/Immunology Cancer
Bergenin is a cytoprotective and antioxidative polyphenol found in many medicinal plants. Bergenin has a wide spectrum activities such as hepatoprotective, antiinflammatory, immunomodulatory, antitumor, antiviral, and antifungal properties .

HY-143230

Custirsen OGX-011	Apoptosis	Cancer
Custirsen (OGX-011) is an antisense oligonucleotide that targets clusterin mRNA. Custirsen induces apoptosis by activating Bax, triggering mitochondrial translocation and cytochrome c release. Custirsen acts as a chemosensitizer, radiosensitizer and hormone sensitizer. Custirsen can be used in research related to prostate cancer, non-small cell lung cancer and metastatic breast cancer .

HY-143230A

Custirsen sodium OGX-011 sodium	Apoptosis	Cancer
Custirsen sodium is a highly specific antisense oligonucleotide that inhibits the production of clusterin , an antiapoptotic protein that is upregulated in response to chemotherapy and that confers treatment resistance.

HY-N0017R

Bergenin (Standard) CuScutin (Standard)	NF-κB Reference Standards Autophagy Apoptosis Bacterial Fungal Virus Protease	Infection Inflammation/Immunology Cancer
Bergenin (Standard) is the analytical standard of Bergenin. This product is intended for research and analytical applications. Bergenin is a cytoprotective and antioxidative polyphenol found in many medicinal plants. Bergenin has a wide spectrum activities such as hepatoprotective, antiinflammatory, immunomodulatory, antitumor, antiviral, and antifungal properties .

HY-119460

Cuspin-1	ERK	Neurological Disease
Cuspin-1 is a upregulator of Survival of Motor Neuron protein (SMN). Cuspin-1 upregulates SMN expression post-transcriptionally, and increases the phosphorylation of Erk. Cuspin-1 can be used for research of neurodegenerative disease, such as spinal muscular atrophy (SMA) .

HY-W777700

Cuscohygrine-d6 (mixture of diastereomers)	Isotope-Labeled Compounds	Others
Cuscohygrine-d₆ (mixture of diastereomers) is the deuterium labeled Cuscohygrine (Mixture of Diastereomers) (HY-N9904).

HY-N3652

Cuspidiol	Fungal	Infection
Cuspidiol (compound 3) is a CH₂Cl₂ extract of Fagara zanthoxyloides Lam. Cuspidiol has antifungal and antioxidative activity .

HY-107310

Cussosaponin C	Others	Others
Cussosaponin C is a compound isolated from Pulsatilla koreana Nakai .

HY-165346

Cuspidoside	Others	Cardiovascular Disease
Cuspidoside is a cardiac glycoside and can be used for the research of cardiovascular disease, such as heart failure .

HY-N17251

Cusculine FAC21	Endonuclease	Infection
Cusculine (FAC21) is an oropouche virus (OROV) endonuclease inhibitor with an IC₅₀ of 1.4 μM. Cusculine strongly interacts with OROV endonuclease, possibly limiting viral RNA interaction with other proteins, intercalates into double-stranded RNA (a viral replication intermediate), and efficiently inhibits OROV viral replication in vitro. Cusculine can be used for the research of oropouche fever .

HY-P99014A

Cusatuzumab (FUT8-KO)	Transmembrane Glycoprotein	Cancer
Cusatuzumab (FUT8-KO) is an anti-CD70 monoclonal antibody that prepared by knocking out the fucosyltransferase 8 gene (FUT8) to remove fucose and thereby enhance the ADCC activity of the antibody .

HY-143230E

FAM labled Custirsen sodium	Fluorescent Dye	Cancer
FAM labled Custirsen sodiumis a FAM labled Custirsen sodium.

HY-143230H

Cy3 labled Custirsen sodium	Fluorescent Dye	Cancer
Cy3 labled Custirsen sodium is a Cy3 labled Custirsen sodium.

HY-143230D

Custirsen sodium scrambled negative control	Apoptosis	Cancer
Custirsen sodium scrambled negative control is the sequence scrambled negative control of Custirsen sodium.

Cat. No.	Product Name	Target	Research Area	Image

HY-P99014

Cusatuzumab 1 Publications Verification ARGX-110	Fc Receptor (FcR) NF-κB	Inflammation/Immunology Cancer
Cusatuzumab (ARGX-110) is a selective competitive blocker targeting CD70 (with an equilibrium dissociation constant of 17 pM for binding to human CD70). Cusatuzumab also possesses enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) activity. It is a humanized IgG1 monoclonal antibody, artificially synthesized through humanization and genetic engineering modifications (CH2 region mutation to enhance effector function). Cusatuzumab has a dual mechanism of action: firstly, it competitively blocks the interaction between CD70 and CD27, inhibiting the CD27-NF-κB signaling pathway, reducing regulatory T cell (Treg) activation and tumor cell proliferation; secondly, by enhancing binding to FcγRIIIa, it mediates ADCC and antibody-dependent cellular phagocytosis (ADCP), directly lysing CD70-positive tumor cells. Cusatuzumab can efficiently eliminate leukemia stem cells (LSCs), induce tumor cell differentiation and apoptosis, restore immune surveillance, and target CD70-positive tumors. Cusatuzumab is used in the study of acute myeloid leukemia (AML) .

HY-P99014A

Cusatuzumab (FUT8-KO)	Transmembrane Glycoprotein	Cancer
Cusatuzumab (FUT8-KO) is an anti-CD70 monoclonal antibody that prepared by knocking out the fucosyltransferase 8 gene (FUT8) to remove fucose and thereby enhance the ADCC activity of the antibody .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0017

Bergenin 5+ Cited Publications CuScutin	Bergenia purpurascens (Hook. f. et Thoms.) Engl. Infection Classification of Application Fields Phenols Polyphenols Saxifragaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	NF-κB Autophagy Apoptosis Bacterial Fungal Virus Protease
Bergenin is a cytoprotective and antioxidative polyphenol found in many medicinal plants. Bergenin has a wide spectrum activities such as hepatoprotective, antiinflammatory, immunomodulatory, antitumor, antiviral, and antifungal properties .

HY-N0017R

Bergenin (Standard) CuScutin (Standard)	Bergenia purpurascens (Hook. f. et Thoms.) Engl. Structural Classification Phenols Polyphenols Saxifragaceae Plants Source Classification	NF-κB Reference Standards Autophagy Apoptosis Bacterial Fungal Virus Protease
Bergenin (Standard) is the analytical standard of Bergenin. This product is intended for research and analytical applications. Bergenin is a cytoprotective and antioxidative polyphenol found in many medicinal plants. Bergenin has a wide spectrum activities such as hepatoprotective, antiinflammatory, immunomodulatory, antitumor, antiviral, and antifungal properties .

HY-N3652

Cuspidiol	Natural Products Rutaceae Plants Fagara zanthoxyloides Lam. Source Classification	Fungal
Cuspidiol (compound 3) is a CH₂Cl₂ extract of Fagara zanthoxyloides Lam. Cuspidiol has antifungal and antioxidative activity .

HY-107310

Cussosaponin C	Triterpenes Classification of Application Fields Terpenoids Ranunculaceae Other Diseases Plants Disease Research Fields Pulsatilla cernua (Thunb.) Bercht. et Opiz. Source Classification	Others
Cussosaponin C is a compound isolated from Pulsatilla koreana Nakai .

HY-165346

Cuspidoside	Structural Classification Cardiacglycosides Convallaria majalis L. Plants Steroids Asparagaceae Juss. Source Classification	Others
Cuspidoside is a cardiac glycoside and can be used for the research of cardiovascular disease, such as heart failure .

HY-N17251

Cusculine FAC21	Structural Classification Alkaloids Rutaceae Acridone Alkaloids Plants Angostura paniculata Source Classification	Endonuclease
Cusculine (FAC21) is an oropouche virus (OROV) endonuclease inhibitor with an IC₅₀ of 1.4 μM. Cusculine strongly interacts with OROV endonuclease, possibly limiting viral RNA interaction with other proteins, intercalates into double-stranded RNA (a viral replication intermediate), and efficiently inhibits OROV viral replication in vitro. Cusculine can be used for the research of oropouche fever .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P73734

	p63/TP73L Protein, Human (sf9, His-GST) Tumor protein 63; p63; CuSP; TP63; p73L	Human	Sf9 insect cells
	The p63/TP73L protein is a sequence-specific DNA-binding transcriptional regulator that exhibits diverse activities through its isoforms. Isoform 2 activates RIPK4 transcription, and binding of this protein to TP73/p73 initiates p53/TP53-dependent apoptosis in response to genotoxic stress. p63/TP73L Protein, Human (sf9, His-GST) is the recombinant human-derived p63/TP73L protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-W777700

Cuscohygrine-d6 (mixture of diastereomers)
Cuscohygrine-d₆ (mixture of diastereomers) is the deuterium labeled Cuscohygrine (Mixture of Diastereomers) (HY-N9904).

Host:	Mouse (2)
Reactivity:	Human (2)
Application:	WB (2) FC (2)
Isotype:	IgG1 (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86745

	p63 Antibody (YA6437) P63_HUMAN; Tumor protein 63; TP63; Chronic ulcerative stomatitis protein(CuSP); Keratinocyte transcription factor KET; Transformation-related protein 63(TP63); Tumor protein p73-like(p73L); p40; p51; KET; P63; P73H; P73L; TP73L; AIS; LMS; NBP; RHS; p40; p51; EEC3; OFC8; SHFM4; TP53L; p53CP; TP53CP; B(p51A); B(p51B); P51A; TAp63gamma; P51B; TAp63alpha; P51delta; TAp63delta; P51delNalpha; deltaNp63 alpha; P51delNbeta; deltaNp63 beta; P51delNgamma; deltaNp63gamma; p40-deltaNp63; p40-deltaNp63;	WB, FC	Human
	p63 Antibody (YA6437) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p63.

HY-P86745A

	p63 Antibody (YA6437)(PBS only) P63_HUMAN; Tumor protein 63; TP63; Chronic ulcerative stomatitis protein(CuSP); Keratinocyte transcription factor KET; Transformation-related protein 63(TP63); Tumor protein p73-like(p73L); p40; p51; KET; P63; P73H; P73L; TP73L; AIS; LMS; NBP; RHS; p40; p51; EEC3; OFC8; SHFM4; TP53L; p53CP; TP53CP; B(p51A); B(p51B); P51A; TAp63gamma; P51B; TAp63alpha; P51delta; TAp63delta; P51delNalpha; deltaNp63 alpha; P51delNbeta; deltaNp63 beta; P51delNgamma; deltaNp63gamma; p40-deltaNp63; p40-deltaNp63;	WB, FC	Human
	p63 Antibody (YA6437) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p63.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-143230

Custirsen OGX-011		Antisense Oligonucleotides
Custirsen (OGX-011) is an antisense oligonucleotide that targets clusterin mRNA. Custirsen induces apoptosis by activating Bax, triggering mitochondrial translocation and cytochrome c release. Custirsen acts as a chemosensitizer, radiosensitizer and hormone sensitizer. Custirsen can be used in research related to prostate cancer, non-small cell lung cancer and metastatic breast cancer .

HY-143230A

Custirsen sodium OGX-011 sodium		Antisense Oligonucleotides
Custirsen sodium is a highly specific antisense oligonucleotide that inhibits the production of clusterin , an antiapoptotic protein that is upregulated in response to chemotherapy and that confers treatment resistance.

HY-143230E

FAM labled Custirsen sodium		Antisense Oligonucleotides
FAM labled Custirsen sodiumis a FAM labled Custirsen sodium.

HY-143230H

Cy3 labled Custirsen sodium		Antisense Oligonucleotides
Cy3 labled Custirsen sodium is a Cy3 labled Custirsen sodium.

HY-143230D

Custirsen sodium scrambled negative control		Antisense Oligonucleotides
Custirsen sodium scrambled negative control is the sequence scrambled negative control of Custirsen sodium.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

CuS

Inhibitors & Agonists

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Natural
Products