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  3. Bergenin

Bergenin  (Synonyms: Cuscutin)

Cat. No.: HY-N0017 Purity: 99.21%
COA Handling Instructions

Bergenin is a cytoprotective and antioxidative polyphenol found in many medicinal plants. Bergenin has a wide spectrum activities such as hepatoprotective, antiinflammatory, immunomodulatory, antitumor, antiviral, and antifungal properties.

For research use only. We do not sell to patients.

Bergenin Chemical Structure

Bergenin Chemical Structure

CAS No. : 477-90-7

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Solution
10 mM * 1 mL in DMSO USD 108 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 108 In-stock
Solid
2 mg USD 60 In-stock
5 mg USD 90 In-stock
10 mg USD 132 In-stock
50 mg USD 396 In-stock
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This product is a controlled substance and not for sale in your territory.

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  • Biological Activity

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Description

Bergenin is a cytoprotective and antioxidative polyphenol found in many medicinal plants. Bergenin has a wide spectrum activities such as hepatoprotective, antiinflammatory, immunomodulatory, antitumor, antiviral, and antifungal properties[1][2].

In Vitro

Bergenin (7.5-30µM; 24 hours) decreases the viability of HeLa cervical cancer cells (IC50=15 µM)[1].
Bergenin (7.5-30 µM; 24 hours) induces apoptosis in HeLa cervical cancer cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HeLa cervical cancer cells
Concentration: 7.5, 15, 30 µM
Incubation Time: 24 hours
Result: Decreased the viability of HeLa cervical cancer cells.

Cell Viability Assay[1]

Cell Line: HeLa cervical cancer cells
Concentration: 7.5, 15, 30 µM
Incubation Time: 24 hours
Result: Induced apoptosis in HeLa cervical cancer cells.
In Vivo

Pretreatment with Bergenin (12.5-100 mg/kg; i.p.; once) produces a dose-related inhibition of acetic acid-induced writhing in mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss Webster C57BL/6 mice[3]
Dosage: 12.5, 25, 50, 100 mg/kg
Administration: i.p.; Once
Result: Produced a dose-related inhibition of acetic acid-induced writhing in mice.
Molecular Weight

328.27

Appearance

Solid

Formula

C14H16O9

CAS No.
SMILES

OC1=C(OC)C(O)=C([C@@]2([H])[C@@](OC3=O)([H])[C@@H](O)[C@H](O)[C@@H](CO)O2)C3=C1

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 103.3 mg/mL (314.68 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0463 mL 15.2314 mL 30.4627 mL
5 mM 0.6093 mL 3.0463 mL 6.0925 mL
10 mM 0.3046 mL 1.5231 mL 3.0463 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.62 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.62 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.62 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Bergenin
Cat. No.:
HY-N0017
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