1. Autophagy
    Apoptosis
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  2. Autophagy
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  3. Bergenin

Bergenin (Synonyms: Cuscutin)

Cat. No.: HY-N0017 Purity: 99.50%
Handling Instructions

Bergenin is a cytoprotective and antioxidative polyphenol found in many medicinal plants. Bergenin has a wide spectrum activities such as hepatoprotective, antiinflammatory, immunomodulatory, antitumor, antiviral, and antifungal properties.

For research use only. We do not sell to patients.

Bergenin Chemical Structure

Bergenin Chemical Structure

CAS No. : 477-90-7

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 108 In-stock
Estimated Time of Arrival: December 31
2 mg USD 60 In-stock
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5 mg USD 90 In-stock
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10 mg USD 132 In-stock
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50 mg USD 396 In-stock
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Description

Bergenin is a cytoprotective and antioxidative polyphenol found in many medicinal plants. Bergenin has a wide spectrum activities such as hepatoprotective, antiinflammatory, immunomodulatory, antitumor, antiviral, and antifungal properties[1][2].

In Vitro

Bergenin (7.5-30µM; 24 hours) decreases the viability of HeLa cervical cancer cells (IC50=15 µM)[1].
Bergenin (7.5-30 µM; 24 hours) induces apoptosis in HeLa cervical cancer cells[1].

Cell Viability Assay[1]

Cell Line: HeLa cervical cancer cells
Concentration: 7.5, 15, 30 µM
Incubation Time: 24 hours
Result: Decreased the viability of HeLa cervical cancer cells.

Cell Viability Assay[1]

Cell Line: HeLa cervical cancer cells
Concentration: 7.5, 15, 30 µM
Incubation Time: 24 hours
Result: Induced apoptosis in HeLa cervical cancer cells.
In Vivo

Pretreatment with Bergenin (12.5-100 mg/kg; i.p.; once) produces a dose-related inhibition of acetic acid-induced writhing in mice[3].

Animal Model: Male Swiss Webster C57BL/6 mice[3]
Dosage: 12.5, 25, 50, 100 mg/kg
Administration: i.p.; Once
Result: Produced a dose-related inhibition of acetic acid-induced writhing in mice.
Molecular Weight

328.27

Formula

C₁₄H₁₆O₉

CAS No.

477-90-7

SMILES

OC1=C(OC)C(O)=C([[email protected]@]2([H])[[email protected]@](OC3=O)([H])[[email protected]@H](O)[[email protected]](O)[[email protected]@H](CO)O2)C3=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (304.63 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0463 mL 15.2314 mL 30.4627 mL
5 mM 0.6093 mL 3.0463 mL 6.0925 mL
10 mM 0.3046 mL 1.5231 mL 3.0463 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.62 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.62 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.62 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

BergeninCuscutinAutophagyApoptosisBacterialFungalVirus ProteaseInhibitorinhibitorinhibit

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Bergenin
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HY-N0017
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