p63 Antibody (YA6437)

Cat. No.: HY-P86745: Ficha de datos User Guide for Antibodies
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p63 Antibody (YA6437) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p63.

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Tamaño		Stock
50 μL		Obtener un presupuesto
100 μL		Obtener un presupuesto

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn

Descripciòn

p63 Antibody (YA6437) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p63.

Host

Mouse

Clonality

Monoclonal

Peso molecular

Predicted band size: 77 kDa

Species Reactivity

Human Predicted Reactivity: Mouse,Rat

Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.

SwissProt ID

Q9H3D4

Gene ID

8626 [NCBI]

Immunogen

KLH conjugated synthetic peptide derived from human P63

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000-5000
FC FC: Flow Cytometry	2ug:Test

Pureza	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter

Subcellular Localization：Nucleus

Expression：
Tissue_Specificity: Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues

Isoforms & Post-Translational Modification：Q9H3D4 has 12 isomers: Q9H3D4-1: 76785 Da (predicted); Q9H3D4-2: 65756 Da (predicted); Q9H3D4-3: 62433 Da (predicted); Q9H3D4-4: 51404 Da (predicted); Q9H3D4-5: 55688 Da (predicted); Q9H3D4-6: 44658 Da (predicted); Q9H3D4-7: 57619 Da (predicted); Q9H3D4-8: 46589 Da (predicted); Q9H3D4-9: 67779 Da (predicted); Q9H3D4-10: 56750 Da (predicted); Q9H3D4-11: 76317 Da (predicted). Q9H3D4-12: 65288 DA (prediction).
May be sumoylated丨Ubiquitinated

Subunit：Binds DNA as a homotetramer

Synonyms

P63_HUMAN; Tumor protein 63; TP63; Chronic ulcerative stomatitis protein(CUSP); Keratinocyte transcription factor KET; Transformation-related protein 63(TP63); Tumor protein p73-like(p73L); p40; p51; KET; P63; P73H; P73L; TP73L; AIS; LMS; NBP; RHS; p40; p51; EEC3; OFC8; SHFM4; TP53L; p53CP; TP53CP; B(p51A); B(p51B); P51A; TAp63gamma; P51B; TAp63alpha; P51delta; TAp63delta; P51delNalpha; deltaNp63 alpha; P51delNbeta; deltaNp63 beta; P51delNgamma; deltaNp63gamma; p40-deltaNp63; p40-deltaNp63;

Documentación

User Guide for Antibodies (1077 KB)