TP63 - tumor protein p63 Gene

Also Known as AIS; KET; LMS; NBP; RHS; p40; p51; p63; EEC3; OFC8; p73H; p73L; SHFM4; TP53L; TP73L; p53CP; TP53CP; B(p51A); B(p51B)

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8626

About TP63

Cytogenetic location: 3q28 Genomic coordinates (GRCh38): 3:189,596,746-189,897,276 (from NCBI)

This gene has 14 transcripts (splice variants), 216 orthologues, 2 paralogues and is associated with 127 phenotypes. Biased expression in skin (RPKM 45.0), esophagus (RPKM 18.6) and 3 other tissues.

Summary

This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016]

TP63 Products (13)

mRNA	Protein	Name
NM_001114978.2	NP_001108450.1	tumor protein 63 isoform 2
NM_001114979.2	NP_001108451.1	tumor protein 63 isoform 3
NM_001114980.2	NP_001108452.1	tumor protein 63 isoform 4
NM_001114981.2	NP_001108453.1	tumor protein 63 isoform 5
NM_001114982.2	NP_001108454.1	tumor protein 63 isoform 6
NM_001329144.2	NP_001316073.1	tumor protein 63 isoform 7
NM_001329145.2	NP_001316074.1	tumor protein 63 isoform 8
NM_001329146.2	NP_001316075.1	tumor protein 63 isoform 9
NM_001329148.2	NP_001316077.1	tumor protein 63 isoform 10
NM_001329149.2	NP_001316078.1	tumor protein 63 isoform 11
NM_001329150.2	NP_001316079.1	tumor protein 63 isoform 12
NM_001329964.2	NP_001316893.1	tumor protein 63 isoform 13
NM_003722.5	NP_003713.3	tumor protein 63 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	25417702	GOA
enables MDM2/MDM4 family protein binding	IPI IPI: Inferred from physical interaction	25417702	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	28827783	GOA
enables WW domain binding	IPI IPI: Inferred from physical interaction	19451233	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	20123734	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	10373484	GOA
enables p53 binding	IPI IPI: Inferred from physical interaction	25417702	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11278685	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	19451233	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12446784	GOA
involved in negative regulation of cellular senescence	IMP IMP: Inferred from mutant phenotype	19451233	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12446784	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	25417702	GOA
involved in positive regulation of Notch signaling pathway	IDA IDA: Inferred from direct assay	11641404	GOA
involved in positive regulation of cell cycle G1/S phase transition	IMP IMP: Inferred from mutant phenotype	19451233	GOA
involved in positive regulation of fibroblast apoptotic process	IDA IDA: Inferred from direct assay	9774969	GOA
involved in positive regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	22521434	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20123734	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	22521434	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10657951	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	20123734	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10657951	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TP63 Protein Structure

P53

P53_tetramer

SAM_2

0
200
400
600
680 a.a.

Protein Preferred Names	Protein Names
tumor protein 63	amplified in squamous cell carcinoma

TP63 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TP63	Q9H3D4	SMAD2	Homo sapiens	Q15796	Anti Bait CoIP	21741598
Intra	TP63	Q9H3D4	YAP1	Homo sapiens	P46937	Pull Down	11278685
Intra	TP63	Q9H3D4	HNRNPAB	Homo sapiens	Q99729	Anti Bait CoIP	20085233
Intra	TP63	Q9H3D4	ITCH	Homo sapiens	Q96J02	Anti Tag CoIP	16908849
Intra	TP63	Q9H3D4	TP63	Homo sapiens	Q9H3D4	X-Ray Diffraction	21464285
Intra	TP63	Q9H3D4	TP73	Homo sapiens	O15350	Anti Tag CoIP	33961781
Intra	TP63	Q9H3D4	TP73	Homo sapiens	O15350	Y2H	22252508
Intra	TP63	Q9H3D4	TP73	Homo sapiens	O15350	SLCA	19815500
Intra	TP63	Q9H3D4	TP53	Homo sapiens	P04637	Anti Bait CoIP	21741598
Intra	TP63	Q9H3D4	TP73	Homo sapiens	O15350	Anti Tag CoIP	34591642
Intra	TP63	Q9H3D4	TP63	Homo sapiens	Q9H3D4	NMR	21335238
Intra	TP63	Q9H3D4	TP63	Homo sapiens	Q9H3D4	Solution Sedimentation	19815500
Intra	TP63	Q9H3D4	TP63	Homo sapiens	Q9H3D4	SLCA	19815500
Intra	TP63	Q9H3D4	HNRNPK	Homo sapiens	P61978	Anti Bait CoIP	20085233
Intra	TP63	Q9H3D4	HIPK2	Homo sapiens	Q9H2X6	Protein Kinase Assay	21602882
Intra	TP63	Q9H3D4	FUS	Homo sapiens	P35637	Anti Bait CoIP	20085233
Intra	TP63	Q9H3D4	PELI2	Homo sapiens	Q9HAT8	Validated Y2H	32296183
Intra	TP63	Q9H3D4	PRKCD	Homo sapiens	Q05655	Anti Tag CoIP	26112605
Intra	TP63	Q9H3D4	TP53BP2	Homo sapiens	Q13625	Solid Phase Assay	18275817

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TP63 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73734	p63/TP73L Protein, Human (sf9, His-GST)	Q9H3D4 (M1-E680)	≥ 90%, as determined by reducing SDS-PAGE.

TP63 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81786	p63 Antibody (YA1531)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
HY-P84795	p63 Antibody (YA4492)	WB, IHC-P, ELISA	Human, Mouse, Rat, Monkey
HY-P84795A	p63 Antibody (YA4492)(PBS only)	WB, IHC-P, ELISA	Human, Mouse, Rat, Monkey
HY-P84796	p63 Antibody (YA4493)	IHC-P, FC, ELISA	Human
HY-P84796A	p63 Antibody (YA4493)(PBS only)	IHC-P, FC, ELISA	Human
HY-P86227	p63 Antibody (YA5919)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86745	p63 Antibody (YA6437)	WB, FC	Human
HY-P86745A	p63 Antibody (YA6437)(PBS only)	WB, FC	Human

Related Diseases

Diseases	Alias
Adult Syndrome	Acro-Dermato-Ungual-Lacrimal-Tooth Syndrome Acro Dermato Ungual Lacrimal Tooth Syndrome Pigment Anomaly-Ectrodactyly-Hypodontia Syndrome Acro-Dermato-Ungual-Lacrimal-Tooth Syndrome Adult
Limb-Mammary Syndrome	LMS Mammary Hypoplasia, Ectrodactyly, And Other Hand/Foot Anomalies
Split-Hand/Foot Malformation 4	SHFM4 Split Hand-Foot Malformation 4 Split-Hand/Foot Malformation, Type 4
Rapp-Hodgkin Syndrome	RHS Anhidrotic Ectodermal Dysplasia With Cleft Lip/Palate Ectodermal Dysplasia, Rapp-Hodgkin Type Rapp-Hodgkin Ectodermal Dysplasia Syndrome Ectodermal Dysplasia, Anhidrotic, With Cleft Lip/Palate Ectodermal Dysplasia Syndrome, Rapp-Hodgkin Type Edrh Rapp-Hodgkin Ectodermal Dysplasia Orofacial Cleft 8
Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate	Hay-Wells Syndrome Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate Syndrome Aec Syndrome AEC Ankyloblepharon-Ectodermal Defects-Cleft Lip And Palate Syndrome Seres-Santamaria Arimany Muniz Syndrome Cleft Palate, Ankyloblepharon, Alveolar Synechiae, And Ectodermal Defects Ankyloblepharon Ectodermal Defects Cleft Lip/Palate Ankyloblepharon-Ectodermal Defect-Cleft Lip/Palate Rapp-Hodgkin Syndrome
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 3	Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome 3 EEC3 Eec Syndrome 3 Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome, Type 3
Orofacial Cleft 8	OFC8 Cleft Lip With Or Without Cleft Palate, Nonsyndromic, 8 Non-Syndromic Cleft Lip/Palate 8 Non-Syndromic Cleft Lip With Or Without Cleft Palate 8 Orofacial Cleft, Type 8
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1	Eec Syndrome Rudiger Syndrome 1 Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome 1 EEC1 Eec Syndrome 1 Eec Syndrome-1 Walker-Clodius Syndrome Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Palate Syndrome Eec Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome Ectrodactyly-Cleft Lip/Palate Syndrome Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Cleft Palate Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome Ectrodactyly, Ectodermal Dysplasia, Clefting Syndrome Ectrodactyly-Cleft Lip-Palate Syndrome Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome
Ankyloblepharon Filiforme Adnatum And Cleft Palate	Ankyloblepharon Filiforme Adnatum AFA Ankyloblepharon Filiforme Adnatum Cleft Palate Ankyloblepharon Filiforme Congenitum Congenital Filiform Fusion Of The Eyelids With Cleft Palate And/Or Cleft Lip Ankyloblepharon Filiforme Adnatum-Cleft Palate Syndrome
Isolated Split Hand-Split Foot Malformation	Ectrodactyly Shfm Split Hand Foot Malformation Split-Hand/Foot Malformation Split Hand Foot Deformity 1 Split Hand Foot Deformity
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Cleft Lip/Palate	Cleft Lip And Palate Alveolar Cleft Lip And Palate Cleft Lip-Alveolus-Palate Syndrome Flp
Ulcerative Stomatitis	Stomatitis Ulcerative Aphthous Stomatitis Minor Oral Aphthous Ulceration
Fissured Tongue	Furrowed Tongue Plicated Tongue Tongue, Fissured Congenital Fissure Of Tongue Congenital Plicated Tongue Fissure Of Tongue Fissure Of Tongue, Congenital Geographic Tongue And Fissured Tongue Lingua Plicata Scrotal Tongue
Bladder Exstrophy	Exstrophy Of The Bladder Classic Exstrophy Of The Bladder
Cleft Lip	Cheiloschisis Labium Leporinum Cleft Lip, Unilateral, Complete Complete Unilateral Cleft Lip Hare Lip Congenital Fissure Of Lip Isolated Cleft Lip Cleft Lip Without Cleft Palate Cleft Lip Without Cleft Palate, Unilateral Isolated Cleft Lip, Unilateral Cleft Lip Without Cleft Palate, Bilateral Isolated Cleft Lip, Bilateral
Ectodermal Dysplasia	Congenital Ectodermal Defect Congenital Ectodermal Dysplasia Ectodermal Dysplasia Syndrome Dysplasia, Ectodermal
Actinic Keratosis	Solar Keratosis Actinic Keratosis Senile Hyperkeratosis Sk - Solar Keratosis Keratosis, Actinic Seborrheic Keratosis Ak - [Actinic Keratosis] Sk - [Solar Keratosis]
Split Hand-Foot Malformation	Ectrodactyly Split-Hand/Foot Malformation Lobster-Claw Deformity Split-Hand Deformity Split Hand Foot Malformation Shfm Split Hand Foot Deformity Split Hand Foot Deformity 1
Oral Lichen Planus	Oral Lichenoid Lesions Lichen Planus Oral Lichen Planus, Oral
Isolated Cleft Lip
Cleft Lip And Alveolus
Adenosquamous Carcinoma	Adenosquamous Cell Carcinoma Mixed Adenocarcinoma And Squamous Carcinoma Carcinoma Adenosquamous Carcinoma, Adenosquamous
Tp63-Related Disorders
Salivary Gland Carcinoma	Salivary Gland Cancer Malignant Neoplasm Of Salivary Gland Salivary Gland Neoplasms
Intraductal Papilloma	Papilloma, Intraductal Ductal Papilloma Papilloma Intraductal
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Squamous Cell Skin Cancer Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Myoepithelioma	Benign Myoepithelioma Myoepithelial Adenoma Myoepithelial Neoplasm Malignant Myoepithelioma
Orofacial Cleft	Cleft, Orofacial
Thymic Carcinoma	Malignant Thymoma Thymoma, Malignant
Clouston Syndrome	Ectodermal Dysplasia 2, Clouston Type Hidrotic Ectodermal Dysplasia ECTD2 Clouston'S Hidrotic Ectodermal Dysplasia Hidrotic Ectodermal Dysplasia Syndrome Clouston Hidrotic Ectodermal Dysplasia Clouston'S Syndrome Ed2 Ectodermal Dysplasia, Hidrotic Hed2 Ectodermal Dysplasia Ectodermal Dysplasia, Hidrotic, Autosomal Dominant Ectodermal Dysplasia, Hidrotic, 2, Formerly Hed2, Formerly Autosomal Dominant Hidrotic Ectodermal Dysplasia Hed Hidrotic Ectodermal Dysplasia, Autosomal Dominant Hidrotic Ectodermal Dysplasia 2 Ectodermal Dysplasia 2 Hidrotic Ectodermal Dysplasia Hidrotic Autosomal Dominant Dysplasia, Ectodermal, Hidrotic
Mucoepidermoid Carcinoma	Mec Salivary Gland Mucoepidermoid Carcinoma C3772 Carcinoma Mucoepidermoid Carcinoma, Mucoepidermoid
Stomatitis
Cervical Squamous Cell Carcinoma	Squamous Cell Carcinoma Of The Cervix Uteri Squamous Cell Carcinoma Of Cervix
Alopecia
Aging
Pleomorphic Adenoma	Mixed Tumor Of The Salivary Gland Adenoma Pleomorphic Adenoma, Pleomorphic Mixed Salivary Gland Tumor Mixed Tumor, Not Otherwise Specified
Split-Hand/Foot Malformation 1	Ectrodactyly Split Hand-Foot Malformation 1 SHFM1 Shfd1 Split-Hand Deformity Split-Hand/Foot Malformation 1 With Or Without Deafness Split-Hand/Foot Deformity 1 Ecd Split Hand/Foot Malformation Type 1 Split Hand Foot Deformity 1 Split-Hand/Foot Malformation
Transitional Cell Carcinoma	Transitional Cell Neoplasm Carcinoma, Transitional Cell Transitional Carcinoma Transitional Cell Tumor Urothelial Cell Carcinoma Carcinoma Transitional Cell Transitional Cell Carcinoma Of Bladder
Main Bronchus Cancer	Malignant Neoplasm Of Main Bronchus Ca Main Bronchus
Cribriform Carcinoma	Ductal Carcinoma, Cribriform Type Carcinoma Cribriform Carcinoma, Cribriform
Neuroendocrine Carcinoma	Neuroendocrine Cancer Carcinoma Neuroendocrine Carcinoma, Neuroendocrine
Papillary Carcinoma	Carcinoma, Papillary Carcinoma Papillary
Adenoid Cystic Carcinoma	Adenocystic Carcinoma Cribriform Carcinoma Cylindroma Carcinoma Adenoid Cystic Carcinoma, Adenoid Cystic Adenoid Cystic Carcinoma Of Salivary Gland Eccrine Dermal Cylindroma Carcinoma, Cribriform
Papilloma	Papillomatosis
Trophoblastic Neoplasm	Trophoblastic Tumor Trophoblastic Neoplasms
Papillary Thyroid Microcarcinoma
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Large Cell Carcinoma	Carcinoma, Large Cell Carcinoma Large Cell
Premature Aging	Syndrome With Premature-Aging
Thymoma	Primary Thymic Epithelial Neoplasm Primary Thymic Epithelial Tumor Thymus Neoplasms
Cleft Palate, Isolated	Cleft Palate Isolated Cleft Palate CPI Cp Palatoschisis Cleft Palate Isolated Uranostaphyloschisis Congenital Fissure Of Palate Cleft Of Secondary Palate
Orofacial Cleft 4	OFC4 Cleft Lip With Or Without Cleft Palate, Nonsyndromic, 4 Nonsyndromic Cleft Lip With Or Without Cleft Palate 4
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Chromosome 2q35 Duplication Syndrome	Syndactyly Syndactyly Type 1 Sdty1 Zygodactyly Syndactyly, Type I Sd1 Syndactyly, Type 1, With Or Without Craniosynostosis Symphalangism Non-Syndromic Syndactyly Symphalangy Webbing Of Digits Syndactyly, Type 1
Laryngeal Squamous Cell Carcinoma	Epidermoid Carcinoma Of The Larynx Squamous Cell Carcinoma Of Larynx Squamous Cell Carcinoma Of The Larynx Squamous Cell Carcinoma Of Head And Neck
Split-Hand/Foot Malformation 1 With Sensorineural Hearing Loss, Autosomal Recessive	Split Hand-Foot Malformation 1 With Sensorineural Hearing Loss SHFM1D Deafness, Congenital, With Split Hands And Feet Split-Hand/Foot Malformation 1 With Sensorineural Hearing Loss Congenital Deafness With Split Hands And Feet Split Hand-Split Foot-Deafness Syndrome Split Hand-Split Foot-Hearing Loss Syndrome Congenital Deafness And Split Hands And Feet Split-Hand/Foot Malformation, Type 1 With Sensorineural Hearing Loss Split-Hand-Foot Malformation With Sensorineural Hearing Loss
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Split-Hand/Foot Malformation 3	SHFM3 Split Hand-Foot Malformation 3 Chromosome 10q24 Duplication Syndrome Shsf3 Limb Deficiencies, Distal, With Micrognathia Split-Hand/Foot Malformation 3, Gene Duplication Syndrome Distal Limb Deficiencies With Micrognathia Limb Deficiencies Distal With Micrognathia Buttiens Fryns Syndrome Distal Limb Deficiencies-Micrognathia Syndrome 10q24 Microduplication Syndrome Buttiens-Fryns Syndrome Split-Hand/Foot Malformation, Type 3, Gene Duplication Syndrome
Nail Disorder, Nonsyndromic Congenital, 1	Nonsyndromic Congenital Nail Disorder 1 Twenty-Nail Dystrophy Claw-Shaped Nails Nail Disorder, Nonsyndromic Congenital, 10 Onycholysis NDNC1 Onychauxis, Hyponychia, And Onycholysis Nonsyndromic Congenital Nail Disorder 10 Idiopathic Trachyonychia Twenty Nail Dystrophy Ndnc10 Onychodystrophy Totalis, Isolated Nail Disorder, Nonsyndromic Congenital, 10, Formerly Ndnc10, Formerly Autosomal Dominant Nail Dysplasia Nail Disorder, Nonsyndromic Congenital 1 Onychodystrophy Totalis Sandpaper Nails Trachyonychia Nail Disorder, Non-Syndromic Congenital, 1 Nail Disorder, Non-Syndromic Congenital, 10 Onychauxis Hyponychia And Onycholysis Nail Disorder, Nonsyndromic Congenital, Type 10 Detachment Of Nail Separation Of Nail Plate
Breast Ductal Carcinoma	Ductal Breast Carcinoma Duct Carcinoma Carcinoma, Ductal Mammary Ductal Carcinoma Ductal Carcinoma
Benign Breast Phyllodes Tumor	Phyllodes Tumor Benign Cystosarcoma Phyllodes Benign Phyllodes Neoplasm Benign Phyllodes Neoplasm Of The Breast Cystosarcoma Phyllodes Phyllodes Neoplasm Phyllodes Tumor, Benign
Skin Benign Neoplasm	Neoplasm Of Skin By Site Tumor Of The Skin Skin Tumor Benign Neoplasm Of Skin Skin Neoplasms
Breast Implant-Associated Anaplastic Large Cell Lymphoma
Cervical Cancer	Cervical Cancer, Somatic Neoplasm Of Uterine Cervix Cervix Cancer Uterine Cervical Neoplasm Cervical Neoplasm Cervix Uteri Cancer Tumor Of The Cervix Uteri CERCA Uterine Cervical Cancer Neoplasms Cervical Uterine Cervical Neoplasms Cervical Cancers Cancer, Cervical, Somatic Malignant Tumor Of Cervix Cervix Carcinoma
Keratoacanthoma	Ka - [Keratoacanthoma] Well-Differentiated Squamous Cell Carcinoma
Amelogenesis Imperfecta	Ai Congenital Enamel Hypoplasia Al - [Amelogenesis Imperfecta]
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Lacrimal Duct Obstruction	Blocked Lacrimal Canaliculus Obstruction Of Lacrimal Canaliculus Obstruction Of Lacrimal Ducts
Epithelioid Sarcoma	Epithelioid Cell Sarcoma Sarcoma Epithelioid Sarcoma, Epithelioid
Van Der Woude Syndrome	Lip-Pit Syndrome Vws Cleft Lip And/Or Palate With Mucous Cysts Of Lower Lip Vdws Lps Lip Pit Syndrome Cleft Lip/Palate With Mucous Cysts Of Lower Lip Myopathy, Actin, Congenital, With Excess Of Thin Myofilaments
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Acute Inflammation Of Lacrimal Passage
Dacryocystitis	Nasolacrimal Sac Infection
Keratosis Follicularis Spinulosa Decalvans, Autosomal Dominant	Autosomal Dominant Keratosis Follicularis Spinulosa Decalvans KFSD
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos
Ankyloglossia With Or Without Tooth Anomalies	Ankyloglossia ANKG 'Tongue-Tie' Tongue-Tie Tongue Tie Aberrant Insertion Of Labial Frenulum Aberrant Insertion Of Frenum Of Tongue Short Frenulum Linguae Short Frenulum Of Tongue
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Mesothelioma, Malignant	Malignant Mesothelioma Pleural Mesothelioma MESOM Mesothelioma, Somatic Advanced Malignant Mesothelioma Asbestos-Related Malignant Mesothelioma Diffuse Malignant Mesothelioma Malignant Tumor Of Mesothelium Malignant Mesothelioma, Susceptibility To Mesothelioma Diffuse Malignant Mesothelioma Malignant Pleural Mesothelioma
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Ectodermal Dysplasia 10b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive	Hypohidrotic Ectodermal Dysplasia Hed Anhidrotic Ectodermal Dysplasia Ectodermal Dysplasia, Hypohidrotic Eda Christ-Siemens-Touraine Syndrome ECTD10B Ectodermal Dysplasia Anhidrotic Ectodermal Dysplasia, Anhidrotic Cst Syndrome Ectodermal Dysplasia Hypohidrotic Autosomal Recessive Dysplasia, Ectodermal, Type 10b, Hypohidrotic/Hair/Tooth, Autosomal Recessive Dysplasia, Ectodermal, Hypohidrotic Ectodermal Dysplasia 11b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive Ectodermal Dysplasia 3, Anhidrotic Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive
Tooth Agenesis	Oligodontia Hypodontia Selective Tooth Agenesis Tooth Agenesis, Selective Familial Tooth Agenesis Anodontia Congenital Absence Of One Tooth
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14923	TP63 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19962	Tcp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24853	Tp63 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TP63	MGD	MGI:1330810
Canis familiaris	TP63	VGNC	VGNC:47729
Rattus norvegicus	TP63	RGD	RGD:620863
Bos taurus	TP63	VGNC	VGNC:36240
Felis catus	TP63	VGNC	VGNC:66467
Macaca mulatta	TP63	VGNC	VGNC:79000
Others	TP63	NCBI