p63 Antibody (YA6437)(PBS only)
(Synonyms: P63_HUMAN; Tumor protein 63; TP63; Chronic ulcerative stomatitis protein(CUSP); Keratinocyte transcription factor KET; Transformation-related protein 63(TP63); Tumor protein p73-like(p73L); p40; p51; KET; P63; P73H; P73L; TP73L; AIS; LMS; NBP; RHS; p40; p51; EEC3; OFC8; SHFM4; TP53L; p53CP; TP53CP; B(p51A); B(p51B); P51A; TAp63gamma; P51B; TAp63alpha; P51delta; TAp63delta; P51delNalpha; deltaNp63 alpha; P51delNbeta; deltaNp63 beta; P51delNgamma; deltaNp63gamma; p40-deltaNp63; p40-deltaNp63; )p63 Antibody (YA6437) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p63.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, FC
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:1000-5000 | 2ug:Test |
Product Details
p63 Antibody (YA6437) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p63.
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Host Mouse
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 77 kDa
KLH conjugated synthetic peptide derived from human P63
affinity purified.
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
p63 acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter
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Subcellular Localization
Nucleus
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Expression
Tissue_Specificity: Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues -
Isoforms & Post-Translational Modification
Q9H3D4 has 12 isomers: Q9H3D4-1: 76785 Da (predicted); Q9H3D4-2: 65756 Da (predicted); Q9H3D4-3: 62433 Da (predicted); Q9H3D4-4: 51404 Da (predicted); Q9H3D4-5: 55688 Da (predicted); Q9H3D4-6: 44658 Da (predicted); Q9H3D4-7: 57619 Da (predicted); Q9H3D4-8: 46589 Da (predicted); Q9H3D4-9: 67779 Da (predicted); Q9H3D4-10: 56750 Da (predicted); Q9H3D4-11: 76317 Da (predicted). Q9H3D4-12: 65288 DA (prediction).
May be sumoylated丨Ubiquitinated -
Subunit
Binds DNA as a homotetramer
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SwissProt ID
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Synonyms
P63_HUMAN; Tumor protein 63; TP63; Chronic ulcerative stomatitis protein(CUSP); Keratinocyte transcription factor KET; Transformation-related protein 63(TP63); Tumor protein p73-like(p73L); p40; p51; KET; P63; P73H; P73L; TP73L; AIS; LMS; NBP; RHS; p40; p51; EEC3; OFC8; SHFM4; TP53L; p53CP; TP53CP; B(p51A); B(p51B); P51A; TAp63gamma; P51B; TAp63alpha; P51delta; TAp63delta; P51delNalpha; deltaNp63 alpha; P51delNbeta; deltaNp63 beta; P51delNgamma; deltaNp63gamma; p40-deltaNp63; p40-deltaNp63;
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