HNRNPAB - heterogeneous nuclear ribonucleoprotein A/B Gene

Homo sapiens

Also known as ABBP1; HNRPAB

Gene ID: 3182 | Gene type: protein coding

About HNRNPAB

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:178,204,533-178,211,163 (from NCBI)

This gene has 8 transcripts (splice variants), 286 orthologues and 36 paralogues. Ubiquitous expression in colon (RPKM 79.0), appendix (RPKM 50.6) and 25 other tissues.

Summary

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

HNRNPAB Products(2)

mRNA	Protein	Name
NM_004499.4	NP_004490.2	heterogeneous nuclear ribonucleoprotein A/B isoform b
NM_031266.3	NP_112556.2	heterogeneous nuclear ribonucleoprotein A/B isoform a

HNRNPAB Protein Structure

CBFNT

RRM_1

0
100
200
300
332 a.a.

Protein Preferred Names

Protein Names

heterogeneous nuclear ribonucleoprotein A/B

ABBP-1

Related Diseases

Diseases

Alias

Oculopharyngeal Muscular Dystrophy

OPMD	Muscular Dystrophy, Oculopharyngeal
Dystrophy, Oculopharyngeal Muscular	Oculopharyngeal Dystrophy
Progressive Muscular Dystrophy, Oculopharyngeal Type	Muscular Dystrophy Oculopharyngeal
Dystrophy, Muscular, Oculopharyngeal

Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate

Hay-Wells Syndrome	Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate Syndrome
Aec Syndrome	AEC
Ankyloblepharon-Ectodermal Defects-Cleft Lip And Palate Syndrome	Seres-Santamaria Arimany Muniz Syndrome
Cleft Palate, Ankyloblepharon, Alveolar Synechiae, And Ectodermal Defects	Ankyloblepharon Ectodermal Defects Cleft Lip/Palate
Ankyloblepharon-Ectodermal Defect-Cleft Lip/Palate	Rapp-Hodgkin Syndrome

Dihydropyrimidine Dehydrogenase Deficiency

Dpd Deficiency	Familial Pyrimidinemia
Hereditary Thymine-Uraciluria	Dihydropyrimidinuria
Dpyd Deficiency	Thymine-Uraciluria, Hereditary
Pyrimidinemia, Familial	5-Fluorouracil Toxicity
Dihydrouracil Dehydrogenase Deficiency	Familial Pyrimidinaemia
Thymine-Uracilurea	Familial Pyrimidemia
Pyrimidinemia Familial	DPYDD

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06264	HNRNPAB Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HNRNPAB	RGD	RGD:69255
Bos taurus	HNRNPAB	VGNC	VGNC:52241
Canis familiaris	HNRNPAB	VGNC	VGNC:56067
Mus musculus	HNRNPAB	MGD	MGI:1330294
Macaca mulatta	HNRNPAB	VGNC	VGNC:73495
Felis catus	HNRNPAB	VGNC	VGNC:102225

Name
Email *

	Sorry, but the email address you supplied was invalid.