p63 Antibody (YA4493)
(Synonyms: TP63,AIS; KET; LMS; NBP; RHS; p40; p51; p63; EEC3; OFC8; p73H; p73L; SHFM4; TP53L; TP73L; p53CP; TP53CP; B(p51A); B(p51B))p63 Antibody (YA4493) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p63.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
p63 Antibody (YA4493) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p63.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 77 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 77 kDa
Purified recombinant fragment of human TP63 (AA: 5-17) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
p63 acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter
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Subcellular Localization
Nucleus
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Expression
Tissue_specificity:This gene is widely expressed in tissues such as the heart, kidneys, placenta, prostate, skeletal muscle, testes, and thymus, but the specific subtype varies depending on the tissue type. The DeltaN subtype is highly expressed in the progenitor cell layer of the skin, breast, eyes, and prostate. Subtype 10 is mainly expressed in squamous cell carcinoma of the skin, but not in normal skin tissue. -
Isoforms & Post-Translational Modification
Q9H3D4 has 12 isomers: Q9H3D4-1: 76785 Da (predicted); Q9H3D4-2: 65756 Da (predicted); Q9H3D4-3: 62433 Da (predicted); Q9H3D4-4: 51404 Da (predicted); Q9H3D4-5: 55688 Da (predicted); Q9H3D4-6: 44658 Da (predicted); Q9H3D4-7: 57619 Da (predicted); Q9H3D4-8: 46589 Da (predicted); Q9H3D4-9: 67779 Da (predicted); Q9H3D4-10: 56750 Da (predicted); Q9H3D4-11: 76317 Da (predicted); Q9H3D4-12: 65288 Da (predicted).
May be sumoylated;Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein -
Subunit
Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity. Isoforms Alpha and Gamma interact with HIPK2. Interacts with SSRP1, leading to stimulate coactivator activity. Isoform 1 and isoform 2 interact with WWP1. Interacts with PDS5A. Isoform 5 (via activation domain) interacts with NOC2L
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SwissProt ID
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Synonyms
TP63,AIS; KET; LMS; NBP; RHS; p40; p51; p63; EEC3; OFC8; p73H; p73L; SHFM4; TP53L; TP73L; p53CP; TP53CP; B(p51A); B(p51B)
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