p63 Antibody (YA4492)

製品番号: HY-P84795: データシート SDS COA User Guide for Antibodies
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p63 Antibody (YA4492) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p63.

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容量	価格（税別）	在庫状況	数量
無料サンプル		今すぐ申し込む
10 μL	$70	在庫あり	Estimated Time of Arrival: December 31
50 μL	$185	在庫あり	Estimated Time of Arrival: December 31
100 μL	$300	在庫あり	Estimated Time of Arrival: December 31
250 μL		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明
参考文献

製品説明

p63 Antibody (YA4492) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p63.

Host

Mouse

Clonality

Monoclonal Antibody

分子量

Predicted band size: 51 kDa;

Observed band size: 51 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat, Monkey

SwissProt ID

Q9H3D4

Gene ID

8626 [NCBI]

Immunogen

Synthesized peptide of human p63α (CARRNKQQRIKEEGE).

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:2000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

純度	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS with 0.05% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter

Subcellular Localization：Nucleus

Expression：
Tissue_specificity:This gene is widely expressed in tissues such as the heart, kidneys, placenta, prostate, skeletal muscle, testes, and thymus, but the specific subtype varies depending on the tissue type. The DeltaN subtype is highly expressed in the progenitor cell layer of the skin, breast, eyes, and prostate. Subtype 10 is mainly expressed in squamous cell carcinoma of the skin, but not in normal skin tissue.

Isoforms & Post-Translational Modification：Q9H3D4 has 12 isomers: Q9H3D4-1: 76785 Da (predicted); Q9H3D4-2: 65756 Da (predicted); Q9H3D4-3: 62433 Da (predicted); Q9H3D4-4: 51404 Da (predicted); Q9H3D4-5: 55688 Da (predicted); Q9H3D4-6: 44658 Da (predicted); Q9H3D4-7: 57619 Da (predicted); Q9H3D4-8: 46589 Da (predicted); Q9H3D4-9: 67779 Da (predicted); Q9H3D4-10: 56750 Da (predicted); Q9H3D4-11: 76317 Da (predicted); Q9H3D4-12: 65288 Da (predicted).
May be sumoylated;Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein

Subunit：Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity. Isoforms Alpha and Gamma interact with HIPK2. Interacts with SSRP1, leading to stimulate coactivator activity. Isoform 1 and isoform 2 interact with WWP1. Interacts with PDS5A. Isoform 5 (via activation domain) interacts with NOC2L

RRID

AB_3718986

Synonyms

P51B; KET; p63α

ドキュメンテーション

Select Batch:

データシート (234 KB) SDS (251 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)

参考文献

[1]. /biology-dictionary/hct-116-cell.html [Content Brief]