2. Cell Cycle/DNA Damage
  3. Endonuclease
  4. Cusculine

Cusculine (FAC21) is an oropouche virus (OROV) endonuclease inhibitor with an IC50 of 1.4 μM. Cusculine strongly interacts with OROV endonuclease, possibly limiting viral RNA interaction with other proteins, intercalates into double-stranded RNA (a viral replication intermediate), and efficiently inhibits OROV viral replication in vitro. Cusculine can be used for the research of oropouche fever.

For research use only. We do not sell to patients.

Cusculine

Cusculine Chemical Structure

CAS No. : 143438-95-3

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Cusculine Related Antibodies

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Description

Cusculine (FAC21) is an oropouche virus (OROV) endonuclease inhibitor with an IC50 of 1.4 μM. Cusculine strongly interacts with OROV endonuclease, possibly limiting viral RNA interaction with other proteins, intercalates into double-stranded RNA (a viral replication intermediate), and efficiently inhibits OROV viral replication in vitro. Cusculine can be used for the research of oropouche fever[1].

In Vitro

Cusculine (FAC21) (72 h) exhibits low cytotoxicity in Vero cells (CC50 = 1640 μM)[1].
Cusculine (15.125-250 μM) potently inhibits OROV infection in Vero cells (EC50 = 33.03 μM)[1].
Cusculine (125 μM; 8-48 hpi) strongly inhibits OROV replication early in Vero cells (99.9% inhibition at 8 hpi)[1].
Cusculine (18.5 μM; 45 min) modestly interacts with dsRNA, showing partial intercalation activity[1].
Cusculine (0-90 μM; 10 min) potently inhibits OROV N-terminal endonuclease as a competitive inhibitor (IC50 = 1.4 μM)[1].
Cusculine stably binds to the active site of OROV N-terminal endonuclease, with favorable binding free energy and conserved interacting residues[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cusculine Related Antibodies
Molecular Weight

345.35

Formula

C18H19NO6
CAS No.
SMILES

O=C1C2=CC=C(OC)C(OC)=C2NC3=CC(OC)=C(OC)C(OC)=C13
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cusculine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cusculine143438-95-3FAC21FAC 21FAC-21EndonucleaseOropouche virusOROVVero cellsviral replication intermediateOROV endonucleaseviral RNAOROV infectionoropouche feverOROV N-terminal endonucleasedouble-stranded RNAInhibitorinhibitorinhibit

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