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Results for "

DNA+minor+groove

" in MedChemExpress (MCE) Product Catalog:

32

Inhibitors & Agonists

5

Fluorescent Dyes

1

Biochemical Assay Reagents

1

Inhibitory Antibodies

2

Natural
Products

2

Isotope-Labeled Compounds

1

GMP Molecules

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-D0814
    DAPI dihydrochloride
    Maximum Cited Publications
    146 Publications Verification

    4',6-Diamidino-2-phenylindole dihydrochloride

    		 DNA Stain Sodium Channel Neurological Disease
    DAPI (4',6-Diamidino-2-phenylindole) dihydrochloride is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. In addition, because DAPI can pass through intact cell membranes, it can be used to stain both live and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm).
    DAPI dihydrochloride
  • HY-16293
    Lurbinectedin
    5+ Cited Publications

    PM01183; LY-01017

    		 DNA Alkylator/Crosslinker DNA/RNA Synthesis Cancer
    Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively.
    Lurbinectedin
  • HY-101161
    SG3199
    3 Publications Verification

    		 DNA Alkylator/Crosslinker ADC Payload Cancer
    SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249) .
    SG3199
  • HY-128952
    Tesirine
    5+ Cited Publications

    SG3249

    		 Drug-Linker Conjugates for ADC DNA Alkylator/Crosslinker Cancer
    Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity .
    Tesirine
  • HY-101127
    SGD-1882

    PBD dimer

    		 ADC Payload Cancer
    SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.
    SGD-1882
  • HY-128915
    Duocarmycin DM free base

    		DNA Alkylator/Crosslinker ADC Payload Cancer
    Duocarmycin DM free base, a DNA minor-groove alkylator, is an antibody agent conjugates (ADCs) toxin. Duocarmycin DM free base is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity .
    Duocarmycin DM free base
  • HY-W040129
    Chromomycin A3
    1 Publications Verification

    		 DNA Alkylator/Crosslinker DNA/RNA Synthesis Apoptosis Caspase Infection Neurological Disease Cancer
    Chromomycin A3 is an inhibitor that selectively binds to GC-rich DNA sequences. Chromomycin A3 targets the DNA minor groove after forming a dimer with Mg 2+. Chromomycin A3 inhibits DNA replication and transcription, blocks the binding of Sp1 transcription factor to target gene promoters, downregulates the expression of anti-apoptotic proteins such as FLIP, Mcl-1, and XIAP, and induces S-phase cycle arrest and caspase-dependent apoptosis in tumor cells. Chromomycin A3 can antagonize oxidative stress induced by glutathione depletion and neuronal apoptosis induced by Camptothecin (HY-15660). Chromomycin A3 can be used in basic research on malignant tumors such as cholangiocarcinoma, and is a potential chemosensitizer and GC-rich region probe .
    Chromomycin A3
  • HY-128904
    MC-Val-Cit-PAB-duocarmycin chloride
    1 Publications Verification

    		 Drug-Linker Conjugates for ADC Cancer
    MC-Val-Cit-PAB-duocarmycin chloride is a agent-linker conjugate for ADC with potent antitumor activity by using Duocarmycin (a DNA minor groove binding alkylating agent), linked via the ADC linker MC-Val-Cit-PAB.
    MC-Val-Cit-PAB-duocarmycin chloride
  • HY-D1738
    DAPI dilactate
    110+ Cited Publications

    4',6-Diamidino-2-phenylindole dilactate

    		 Fluorescent Dye Others
    DAPI (4',6-Diamidino-2-phenylindole) dilactate is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining both live and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm) .
    DAPI dilactate
  • HY-D2868
    DAPI
    130+ Cited Publications

    4',6-Diamidino-2-phenylindole

    		 DNA Stain Sodium Channel Neurological Disease
    DAPI (4',6-Diamidino-2-phenylindole) is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. In addition, because DAPI can pass through intact cell membranes, it can be used to stain both live and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm).
    DAPI
  • HY-172663A
    Trabectedin derivative 1 TFA

    		DNA/RNA Synthesis Apoptosis Cancer
    Trabectedin derivative 1 TFA is a selective DNA minor groove binder. Trabectedin derivative 1 TFA inhibits DNA transcription and repair to induce tumor cell apoptosis. Trabectedin derivative 1 TFA is promising for research of solid tumors such as soft tissue sarcoma and ovarian cancer .
    Trabectedin derivative 1 TFA
  • HY-157465
    MA-PEG4-VC-PAB-DMEA-duocarmycin DM

    		Drug-Linker Conjugates for ADC Cancer
    MA-PEG4-VC-PAB-DMEA-duocarmycin DM is a drug-linker conjugate for ADC by using the DNA minor-groove alkylator Duocarmycin DM (HY-130978), linked via MA-PEG4-vc-PAB-DMEA (HY-126668).
    MA-PEG4-VC-PAB-DMEA-duocarmycin DM
  • HY-130978
    Duocarmycin DM

    		DNA Alkylator/Crosslinker ADC Payload Cancer
    Duocarmycin DM, a DNA minor-groove alkylator, is an antibody agent conjugates (ADCs) toxin. Duocarmycin DM is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity .
    Duocarmycin DM
  • HY-16293S
    Lurbinectedin-d3

    PM01183-d3; LY-01017-d3

    		 DNA Alkylator/Crosslinker DNA/RNA Synthesis Cancer
    Lurbinectedin-d3 is deuterium labeled Lurbinectedin. Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively .
    Lurbinectedin-d3
  • HY-135900
    Aniline-MPB-amino-C3-PBD

    		ADC Payload Bacterial Cancer
    Aniline-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Aniline-MPB-amino-C3-PBD is a sequence-selective DNA minor-groove binding agent. Aniline-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity .
    Aniline-MPB-amino-C3-PBD
  • HY-175269
    MGB1Y

    		DNA Alkylator/Crosslinker DNA/RNA Synthesis Topoisomerase Cancer
    MGB1Y is a noncovalent DNA minor groove binder (MGB). MGB1Y potently inhibits cancer cells proliferation and topoisomerase I activity. MGB1Y downregulates their breast cancer-related genes in MCF7 and MDA-MB-231 cells. MGB1Y has a broad-spectrum anticancer activity, such as breast cancer, colon cancer, and leukemia .
    MGB1Y
  • HY-178174
    MGB4

    		DNA/RNA Synthesis Topoisomerase Cancer
    MGB4 is a DNA minor groove binder. MGB4 binds to ARE-containing DNA and inhibition of topoisomerase I activity. MGB4 can impacts key cellular pathways, including inhibition oftranslation and alterations in sphingolipid and amino acid metabolism. MGB4 also reduces spermine and spermidine metabolism companied with Doxorubicin (HY-15142A). MGB4 can be used for the research of cancer, such as Prostate cancer .
    MGB4
  • HY-D1396
    Br-DAPI
    3 Publications Verification

    		 Fluorescent Dye DNA Stain Others
    Br-DAPI is a marker dye in DAPI series. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. In addition, because DAPI can pass through intact cell membranes, it can be used to stain both live and fixed cells . Storage: Keep away from light.
    Br-DAPI
  • HY-128952G
    Tesirine

    SG3249

    		 Drug-Linker Conjugates for ADC DNA Alkylator/Crosslinker Cancer
    Tesirine (GMP) (SG3249 (GMP)) is Tesirine (HY-128952) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity .
    Tesirine
  • HY-126782
    Lexitropsin 1

    		DNA Alkylator/Crosslinker Infection
    Lexitropsin 1 is a DNA minor groove binder with a delta G degree of 65 kJ/mol at 303 K. Lexitropsin 1 has antiviral activity .
    Lexitropsin 1
  • HY-144336
    DNA crosslinker 3 dihydrochloride

    		DNA Alkylator/Crosslinker Cancer
    DNA crosslinker 3 (dihydrochloride) (compound 1) is a potent DNA minor groove binder with DNA binding affinity (ΔTm) of 1.4 °C. DNA crosslinker 3 (dihydrochloride) can be used for researching anticancer .
    DNA crosslinker 3 dihydrochloride
  • HY-144333
    DNA crosslinker 1 dihydrochloride

    		DNA Alkylator/Crosslinker Cancer
    DNA crosslinker 1 dihydrochloride (Compound 4) is a potent DNA minor groove binder with DNA binding affinity (ΔTm) of 1.1 °C. DNA crosslinker 1 dihydrochloride can be used for researching anticancer .
    DNA crosslinker 1 dihydrochloride
  • HY-144337
    DNA crosslinker 4 dihydrochloride

    		DNA Alkylator/Crosslinker Cancer
    DNA crosslinker 4 (dihydrochloride) is a potent DNA minor groove binder. DNA crosslinker 4 (dihydrochloride) has certain inhibitory activity against cancer cells NCI-H460, A2780 and MCF-7. DNA crosslinker 4 (dihydrochloride) can be used for researching anticancer .
    DNA crosslinker 4 dihydrochloride
  • HY-157465A
    MA-PEG4-VC-PAB-DMEA-duocarmycin DM TFA

    		Drug-Linker Conjugates for ADC Cancer
    MA-PEG4-VC-PAB-DMEA-duocarmycin DM TFA is a drug-linker conjugate for ADC by using the DNA minor-groove alkylator Duocarmycin DM (HY-130978), linked via MA-PEG4-vc-PAB-DMEA (HY-126668).
    MA-PEG4-VC-PAB-DMEA-duocarmycin DM TFA
  • HY-144335
    DNA crosslinker 2 dihydrochloride

    		DNA Alkylator/Crosslinker Cancer
    DNA crosslinker 2 (dihydrochloride) is a potent DNA minor groove binder with DNA binding affinity (ΔTm) of 1.2 °C. DNA crosslinker 2 (dihydrochloride) has certain inhibitory activity against cancer cells NCI-H460, A2780 and MCF-7. DNA crosslinker 2 (dihydrochloride) can be used for researching anticancer .
    DNA crosslinker 2 dihydrochloride
  • HY-152187
    Topoisomerase IIα-IN-5

    		Topoisomerase Apoptosis Others
    Topoisomerase IIα-IN-5 is a topoisomerase II (topo II) α catalytic inhibitor. Topoisomerase IIα-IN-5 intercalates into DNA and binds to the DNA minor groove. Topoisomerase IIα-IN-5 exhibits better efficacy and less genotoxicity than Etoposide (HY-13629) .
    Topoisomerase IIα-IN-5
  • HY-W040129R
    Chromomycin A3 (Standard)

    		Reference Standards Bacterial Fungal Apoptosis Antibiotic Infection Neurological Disease Cancer
    Chromomycin A3 (Standard) is the analytical standard of Chromomycin A3 (HY-W040129). This product is intended for research and analytical applications. Chromomycin A3 is an inhibitor that selectively binds to GC-rich DNA sequences. Chromomycin A3 targets the DNA minor groove after forming a dimer with Mg 2+. Chromomycin A3 inhibits DNA replication and transcription, blocks the binding of Sp1 transcription factor to target gene promoters, downregulates the expression of anti-apoptotic proteins such as FLIP, Mcl-1, and XIAP, and induces S-phase cycle arrest and caspase-dependent apoptosis in tumor cells. Chromomycin A3 can antagonize oxidative stress induced by glutathione depletion and neuronal apoptosis induced by Camptothecin (HY-15660). Chromomycin A3 can be used in basic research on malignant tumors such as cholangiocarcinoma, and is a potential chemosensitizer and GC-rich region probe .
    Chromomycin A3 (Standard)
  • HY-101161S
    SG3199-d6

    		Isotope-Labeled Compounds DNA Alkylator/Crosslinker ADC Payload Cancer
    SG3199-d6 is the deuterium labeled SG3199 (HY-101161). SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249).
    SG3199-d6
  • HY-101161R
    SG3199 (Standard)

    		Reference Standards DNA Alkylator/Crosslinker ADC Payload Cancer
    SG3199 (Standard) is the analytical standard of SG3199 (HY-101161). This product is intended for research and analytical applications. SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249) .
    SG3199 (Standard)
  • HY-P991862
    CDX-0125-TEI Antibody

    		ADC Antibody Anaplastic lymphoma kinase (ALK) Cancer
    CDX-0125-TEI Antibody is an anti-human ALK antibody. AMG-224 Antibody can generate antibody drug conjugate (ADC) (CDX-0125-TEI) with thienoindole (TEI) DNA minor groove alkylating agent. CDX-0125-TEI Antibody can be used for the study of neuroblastoma .
    CDX-0125-TEI Antibody
  • HY-185494
    Mal-Val-Lys-PAB-CBI-PBD dimer

    		Drug-Linker Conjugates for ADC DNA Alkylator/Crosslinker Cancer
    Mal-Val-Lys-PAB-CBI-PBD dimer is a Drug-Linker Conjugates for ADC. Mal-Val-Lys-PAB-CBI-PBD dimer consists of the ADC Cytotoxin CBI-PBD dimer and a linker Mal-Val-Lys-PAB. Mal-Val-Lys-PAB-CBI-PBD dimer exhibits alkylating activity at A-T-rich DNA minor groove adenine residues, disrupting DNA integrity. Mal-Val-Lys-PAB-CBI-PBD dimer induces cancer cell growth inhibition and cellular death. Mal-Val-Lys-PAB-CBI-PBD dimer can be used for the research of cancer .
    Mal-Val-Lys-PAB-CBI-PBD dimer
  • HY-DY1081
    DAPI dihydrochloride (solution)

    4',6-Diamidino-2-phenylindole dihydrochloride (solution)

    		 Sodium Channel DNA Stain Neurological Disease
    DAPI (4',6-Diamidino-2-phenylindole) dihydrochloride (solution) is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. In addition, because DAPI can pass through intact cell membranes, it can be used to stain both live and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm).
    Solvent and concentration: ddH2O: 5 mg/mL
    DAPI dihydrochloride (solution)

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