MC-Val-Cit-PAB-duocarmycin chloride
Based on 1 publication(s) in Google Scholar
MC-Val-Cit-PAB-duocarmycin chloride is a agent-linker conjugate for ADC with potent antitumor activity by using Duocarmycin (a DNA minor groove binding alkylating agent), linked via the ADC linker MC-Val-Cit-PAB.
For research use only. We do not sell to patients.
- Purity: 99.04%
- CAS No.: 2055896-98-3
- Formula: C54H65Cl2N9O9
- Molecular Weight:1055.05
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Storage:
-80°C, protect from light, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) MC-Val-Cit-PAB-duocarmycin chloride
MoreAll Drug-Linker Conjugates for ADC Isoforms
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Biological Activity
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Duocarmycins |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2055896-98-3
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Appearance Solid
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Molecular Weight 1055.05
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Formula C54H65Cl2N9O9
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Color White to light yellow
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SMILES
ClC[C@H]1C2=C(C=C(O)C3=CC=CC=C23)N(C(C4=CC5=CC(OCC[N+](C)(C)CC6=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN7C(C=CC7=O)=O)=O)=O)=O)C=C6)=CC=C5N4)=O)C1.[Cl-]
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Shipping
Shipping with dry ice.
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Storage
-80°C, protect from light, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Cell Mol Med
8C7: A Fully Human Anti-PTGFRN Monoclonal Antibody-Drug Conjugate Inhibiting Tumour Growth of Mesothelioma and Paediatric Medulloblastoma Cell Lines. [Abstract]2025 Jun;29(12):e70665. PMID: 40551322
Solvent & Solubility
DMSO : ≥ 100 mg/mL (94.78 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9478 mL | 4.7391 mL | 9.4782 mL | 23.6956 mL |
| 5 mM | 0.1896 mL | 0.9478 mL | 1.8956 mL | 4.7391 mL | |
| 10 mM | 0.0948 mL | 0.4739 mL | 0.9478 mL | 2.3696 mL | |
| 15 mM | 0.0632 mL | 0.3159 mL | 0.6319 mL | 1.5797 mL | |
| 20 mM | 0.0474 mL | 0.2370 mL | 0.4739 mL | 1.1848 mL | |
| 25 mM | 0.0379 mL | 0.1896 mL | 0.3791 mL | 0.9478 mL | |
| 30 mM | 0.0316 mL | 0.1580 mL | 0.3159 mL | 0.7899 mL | |
| 40 mM | 0.0237 mL | 0.1185 mL | 0.2370 mL | 0.5924 mL | |
| 50 mM | 0.0190 mL | 0.0948 mL | 0.1896 mL | 0.4739 mL | |
| 60 mM | 0.0158 mL | 0.0790 mL | 0.1580 mL | 0.3949 mL | |
| 80 mM | 0.0118 mL | 0.0592 mL | 0.1185 mL | 0.2962 mL |
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