1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. MC-Val-Cit-PAB-duocarmycin chloride

MC-Val-Cit-PAB-duocarmycin chloride 

Cat. No.: HY-128904 Purity: 90.01%
COA Handling Instructions

MC-Val-Cit-PAB-duocarmycin chloride is a agent-linker conjugate for ADC with potent antitumor activity by using Duocarmycin (a DNA minor groove binding alkylating agent), linked via the ADC linker MC-Val-Cit-PAB.

For research use only. We do not sell to patients.

MC-Val-Cit-PAB-duocarmycin chloride Chemical Structure

MC-Val-Cit-PAB-duocarmycin chloride Chemical Structure

CAS No. : 2055896-98-3

Size Price Stock Quantity
5 mg USD 1150 In-stock
10 mg USD 1950 In-stock
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100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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Description

MC-Val-Cit-PAB-duocarmycin chloride is a agent-linker conjugate for ADC with potent antitumor activity by using Duocarmycin (a DNA minor groove binding alkylating agent), linked via the ADC linker MC-Val-Cit-PAB.

IC50 & Target

Duocarmycins

 

Molecular Weight

1055.05

Formula

C54H65Cl2N9O9

CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

ClC[C@H]1C2=C(C=C(O)C3=CC=CC=C23)N(C(C4=CC5=CC(OCC[N+](C)(C)CC6=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN7C(C=CC7=O)=O)=O)=O)=O)C=C6)=CC=C5N4)=O)C1.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 130 mg/mL (123.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9478 mL 4.7391 mL 9.4782 mL
5 mM 0.1896 mL 0.9478 mL 1.8956 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.16%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9478 mL 4.7391 mL 9.4782 mL 23.6956 mL
5 mM 0.1896 mL 0.9478 mL 1.8956 mL 4.7391 mL
10 mM 0.0948 mL 0.4739 mL 0.9478 mL 2.3696 mL
15 mM 0.0632 mL 0.3159 mL 0.6319 mL 1.5797 mL
20 mM 0.0474 mL 0.2370 mL 0.4739 mL 1.1848 mL
25 mM 0.0379 mL 0.1896 mL 0.3791 mL 0.9478 mL
30 mM 0.0316 mL 0.1580 mL 0.3159 mL 0.7899 mL
40 mM 0.0237 mL 0.1185 mL 0.2370 mL 0.5924 mL
50 mM 0.0190 mL 0.0948 mL 0.1896 mL 0.4739 mL
60 mM 0.0158 mL 0.0790 mL 0.1580 mL 0.3949 mL
80 mM 0.0118 mL 0.0592 mL 0.1185 mL 0.2962 mL
100 mM 0.0095 mL 0.0474 mL 0.0948 mL 0.2370 mL
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MC-Val-Cit-PAB-duocarmycin chloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
MC-Val-Cit-PAB-duocarmycin chloride
Cat. No.:
HY-128904
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