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Cat. No.: HY-157465

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MA-PEG4-VC-PAB-DMEA-duocarmycin DM

Name: MA-PEG4-VC-PAB-DMEA-duocarmycin DM
Brand: MedChemExpress
SKU: HY-157465
Price: 1043.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Based on 1 Customer Validation

MA-PEG4-VC-PAB-DMEA-duocarmycin DM is a drug-linker conjugate for ADC by using the DNA minor-groove alkylator Duocarmycin DM (HY-130978), linked via MA-PEG4-vc-PAB-DMEA (HY-126668).

For research use only. We do not sell to patients.

Purity: 99.84%
Formula: C₆₈H₈₉ClN₁₂O₁₇
Molecular Weight:1381.96

Storage:

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

MA-PEG4-VC-PAB-DMEA-duocarmycin DM Chemical Structure

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One-Stop Platform：From Independent R&D to Pilot-Scale Production

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

MA-PEG4-VC-PAB-DMEA-duocarmycin DM is a drug-linker conjugate for ADC by using the DNA minor-groove alkylator Duocarmycin DM (HY-130978), linked via MA-PEG4-vc-PAB-DMEA (HY-126668).

IC₅₀ & Target^[1]

Traditional Cytotoxic Agents

All Drug-Linker Conjugates for ADC Isoforms :

In Vitro

Antibody-drug conjugates (ADCs) are drug-adaptor conjugates consisting of an active cytotoxic drug and a suitable adaptor. These conjugates, when linked to monoclonal antibodies, can be used to prepare ADCs, which are highly selective and cytotoxic targeting drugs against cancer cells.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Appearance Solid
Molecular Weight 1381.96
Formula C₆₈H₈₉ClN₁₂O₁₇
Color White to off-white
SMILES

O=C(NCCOCCOCCOCCOCCC(N[C@H](C(N[C@H](C(NC1=CC=C(COC(N(CCN(C(OC2=CC3=C([C@@H](CN3C(C4=CC5=CC(OCCN(C)C)=CC=C5N4)=O)CCl)C6=CC=CC=C26)=O)C)C)=O)C=C1)=O)CCCNC(N)=O)=O)C(C)C)=O)CCN7C(C=CC7=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Patil PC, et al. A Short Review on the Synthetic Strategies of Duocarmycin Analogs that are Powerful DNA Alkylating Agents. Anticancer Agents Med Chem. 2015;15(5):616-30. [Content Brief]

[2]. Italo Beria, et al. New alkylating agents. Franch, WO2013149948A1.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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MA-PEG4-VC-PAB-DMEA-duocarmycin DM

All Drug-Linker Conjugates for ADC Isoforms