1. Cell Cycle/DNA Damage
  2. DNA Alkylator/Crosslinker
  3. DNA crosslinker 4 dihydrochloride

DNA crosslinker 4 dihydrochloride 

Cat. No.: HY-144337
Handling Instructions

DNA crosslinker 4 (dihydrochloride) is a potent DNA minor groove binder. DNA crosslinker 4 (dihydrochloride) has certain inhibitory activity against cancer cells NCI-H460, A2780 and MCF-7. DNA crosslinker 4 (dihydrochloride) can be used for researching anticancer.

For research use only. We do not sell to patients.

DNA crosslinker 4 dihydrochloride Chemical Structure

DNA crosslinker 4 dihydrochloride Chemical Structure

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Description

DNA crosslinker 4 (dihydrochloride) is a potent DNA minor groove binder. DNA crosslinker 4 (dihydrochloride) has certain inhibitory activity against cancer cells NCI-H460, A2780 and MCF-7. DNA crosslinker 4 (dihydrochloride) can be used for researching anticancer[1].

IC50 & Target

IC50: 21 ± 1 μM in A2780 cells[1]

In Vitro

DNA crosslinker 4 (dihydrochloride) (compound 2) (100 μM; 48 h or 96 h) exhibits inhibitory activity against NCI-H460, A2780 and MCF-7[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line: NCI-H460, A2780 and MCF-7[1]
Concentration: 100 μM
Incubation Time: 48 h (NCI-H460) and 96 h (A2780 and MCF-7)
Result: Exhibited inhibitory activity against NCI-H460, A2780 and MCF-7 with inhibition percentage of 34%, 59% and 22% at 100 μM; and showed an IC50 value of 21 ± 1 μM in A2780 cells.
Molecular Weight

415.32

Formula

C16H24Cl2N8O

SMILES

CC1=CC(N(N=C1CNC(N)=N)CC2=CC=C(C=C2)CNC(N)=N)=O.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
DNA crosslinker 4 dihydrochloride
Cat. No.:
HY-144337
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