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Cat. No.: HY-144337

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DNA crosslinker 4 dihydrochloride

DNA crosslinker 4 (dihydrochloride) is a potent DNA minor groove binder. DNA crosslinker 4 (dihydrochloride) has certain inhibitory activity against cancer cells NCI-H460, A2780 and MCF-7. DNA crosslinker 4 (dihydrochloride) can be used for researching anticancer.

For research use only. We do not sell to patients.

CAS No.: 2761734-23-8
Formula: C₁₆H₂₄Cl₂N₈O
Molecular Weight:415.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

DNA crosslinker 4 dihydrochloride Chemical Structure

CAS No.: 2761734-23-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

IC₅₀: 21 ± 1 μM in A2780 cells^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	21 μM Compound: 2	Cytotoxicity against human A2780 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay Cytotoxicity against human A2780 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 35300077]

In Vitro

DNA crosslinker 4 (dihydrochloride) (compound 2) (100 μM; 48 h or 96 h) exhibits inhibitory activity against NCI-H460, A2780 and MCF-7^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:

NCI-H460, A2780 and MCF-7^[1]
Concentration:

100 μM
Incubation Time:

48 h (NCI-H460) and 96 h (A2780 and MCF-7)
Result:

Exhibited inhibitory activity against NCI-H460, A2780 and MCF-7 with inhibition percentage of 34%, 59% and 22% at 100 μM; and showed an IC₅₀ value of 21 ± 1 μM in A2780 cells.

Chemical Information

CAS No. 2761734-23-8
Molecular Weight 415.32
Formula C₁₆H₂₄Cl₂N₈O
SMILES

CC1=CC(N(N=C1CNC(N)=N)CC2=CC=C(C=C2)CNC(N)=N)=O.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Costas-Lago MC, et al. Novel Pyridazin-3(2H)-one-Based Guanidine Derivatives as Potential DNA Minor Groove Binders with Anticancer Activity. ACS Med Chem Lett. 2022;13(3):463-469. Published 2022 Feb 10. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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