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Cat. No.: HY-185494

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Mal-Val-Lys-PAB-CBI-PBD dimer

Mal-Val-Lys-PAB-CBI-PBD dimer is a Drug-Linker Conjugates for ADC. Mal-Val-Lys-PAB-CBI-PBD dimer consists of the ADC Cytotoxin CBI-PBD dimer and a linker Mal-Val-Lys-PAB. Mal-Val-Lys-PAB-CBI-PBD dimer exhibits alkylating activity at A-T-rich DNA minor groove adenine residues, disrupting DNA integrity. Mal-Val-Lys-PAB-CBI-PBD dimer induces cancer cell growth inhibition and cellular death. Mal-Val-Lys-PAB-CBI-PBD dimer can be used for the research of cancer.

For research use only. We do not sell to patients.

CAS No.: 1661824-39-0
Formula: C₆₇H₈₅ClN₁₀O₁₄
Molecular Weight:1289.90

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Please store the product under the recommended conditions in the Certificate of Analysis.

Mal-Val-Lys-PAB-CBI-PBD dimer Chemical Structure

CAS No.: 1661824-39-0

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Biological Activity

Description

All Drug-Linker Conjugates for ADC Isoforms :

In Vitro

Mal-Val-Lys-PAB-CBI-PBD dimer (Compound CBI-PBD dimer- linker (B)) can be used to synthesize HER2-targeting and CD22-targeting ADCs mediates antigen-dependent growth inhibition and cell death in HER2-positive and CD22-positive cancer cells in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1661824-39-0
Molecular Weight 1289.90
Formula C₆₇H₈₅ClN₁₀O₁₄
SMILES

O=C1C=CC(N1CCCCCC(N[C@H](C(N[C@@H](CCCCN)C(NC(C=C2)=CC=C2COC(N(C3=CC(OCCCCCC(N(C4)C(C=C(C5=CC=CC=C56)OC(N7CCN(C)CC7)=O)=C6[C@@H]4CCl)=O)=C(OC)C=C83)C(O)[C@@]9(CCCN9C8=O)[H])=O)=O)=O)C(C)C)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yao HP, et al. Duocarmycin-based antibody-drug conjugates as an emerging biotherapeutic entity for targeted cancer therapy: Pharmaceutical strategy and clinical progress. Drug Discov Today. 2021;26(8):1857-1874. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Mal-Val-Lys-PAB-CBI-PBD dimer

All Drug-Linker Conjugates for ADC Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Mal-Val-Lys-PAB-CBI-PBD dimer Related Classifications

HY-185494 Related Classifications