1661824-39-0
Chemical Structure
Mal-Val-Lys-PAB-CBI-PBD dimer
- CAS No.: 1661824-39-0
- Formula:C67H85ClN10O14
- Molecular Weight:1289.90
InChIKey: YWJYCLYNDYGCRB-YNZULSGDSA-N
SMILES: O=C1C=CC(N1CCCCCC(N[C@H](C(N[C@@H](CCCCN)C(NC(C=C2)=CC=C2COC(N(C3=CC(OCCCCCC(N(C4)C(C=C(C5=CC=CC=C56)OC(N7CCN(C)CC7)=O)=C6[C@@H]4CCl)=O)=C(OC)C=C83)C(O)[C@@]9(CCCN9C8=O)[H])=O)=O)=O)C(C)C)=O)=O
Biological Activity: Mal-Val-Lys-PAB-CBI-PBD dimer is a Drug-Linker Conjugates for ADC. Mal-Val-Lys-PAB-CBI-PBD dimer consists of the ADC Cytotoxin CBI-PBD dimer and a linker Mal-Val-Lys-PAB. Mal-Val-Lys-PAB-CBI-PBD dimer exhibits alkylating activity at A-T-rich DNA minor groove adenine residues, disrupting DNA integrity. Mal-Val-Lys-PAB-CBI-PBD dimer induces cancer cell growth inhibition and cellular death. Mal-Val-Lys-PAB-CBI-PBD dimer can be used for the research of cancer[1].
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Mal-Val-Lys-PAB-CBI-PBD dimer | Mal-Val-Lys-PAB-CBI-PBD dimer is a Drug-Linker Conjugates for ADC. Mal-Val-Lys-PAB-CBI-PBD dimer consists of the ADC Cytotoxin CBI-PBD dimer and a linker Mal-Val-Lys-PAB. Mal-Val-Lys-PAB-CBI-PBD dimer exhibits alkylating activity at A-T-rich DNA minor groove adenine residues, disrupting DNA integrity. Mal-Val-Lys-PAB-CBI-PBD dimer induces cancer cell growth inhibition and cellular death. Mal-Val-Lys-PAB-CBI-PBD dimer can be used for the research of cancer. | |||||||||||||||||||||
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Keywords
