1. Antibody-drug Conjugate/ADC Related
    Anti-infection
  2. ADC Cytotoxin
    Bacterial
  3. Aniline-MPB-amino-C3-PBD

Aniline-MPB-amino-C3-PBD 

Cat. No.: HY-135900
Handling Instructions

Aniline-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Aniline-MPB-amino-C3-PBD is a sequence-selective DNA minor-groove binding agent. Aniline-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity.

For research use only. We do not sell to patients.

Aniline-MPB-amino-C3-PBD Chemical Structure

Aniline-MPB-amino-C3-PBD Chemical Structure

CAS No. : 2412923-79-4

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Description

Aniline-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Aniline-MPB-amino-C3-PBD is a sequence-selective DNA minor-groove binding agent. Aniline-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity[1].

IC50 & Target[1]

Pyrrolobenzodiazepines

 

In Vitro

Aniline-MPB-amino-C3-PBD (compound 16) shows cytotoxicity with IC50s of 77, 72, 79, 184.3, 61.5, and 145.6 nM for SW48, LIM1215, SW620, U138-MG, A431, and REH cells, respectively. Aniline-MPB-amino-C3-PBD effectively stabilises DNA with a degree of sequence-specificity. Aniline-MPB-amino-C3-PBD possesses potent anti-bacterial effects against the gram negative strain E. coli K12 with potency of 2 pg/mL determined[1].

Molecular Weight

758.86

Formula

C₄₂H₄₆N₈O₆

CAS No.

2412923-79-4

SMILES

O=C(N(CCCC1)[[email protected]]1([H])CN2)C3=C2C=C(OCCCC(NC4=CN(C)C(C(NC5=CC=C(C6=CN(C)C(C(NC7=CC=C(N)C=C7)=O)=C6)C=C5)=O)=C4)=O)C(OC)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Aniline-MPB-amino-C3-PBDADC CytotoxinBacterialDNAsequence-specificityPBDminor-groovepayloadSW48SW620cellsE. coliInhibitorinhibitorinhibit

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Aniline-MPB-amino-C3-PBD
Cat. No.:
HY-135900
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